Pancreas News and Research

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The pancreas is a gland organ in the digestive and endocrine system of vertebrates. It is both an endocrine gland producing several important hormones, including insulin, glucagon, and somatostatin, as well as an exocrine gland, secreting pancreatic juice containing digestive enzymes that pass to the small intestine. These enzymes help in the further breakdown of the carbohydrates, protein, and fat in the chyme.

Pancreatic cancer cells find alternative source of nutrition to avoid starvation

Pancreatic cancer cells avert starvation in dense tumors by ordering nearby support cells to supply them with an alternative source of nutrition.

11 Aug 2016

Diabetes mellitis coexisting with solid-organ malignancies linked to hospitalization risks

Future Science Group today announced the publication of a new article in Future Science OA examining the effects of diabetes on hospitalization risk, chances of multiple admissions, and length of hospitalization stay, for patients suffering from solid-organ malignancies such as breast, colorectal, lung and pancreas, among others.

10 Aug 2016

SBP researchers discover potential drug target for treatment of type 2 diabetes

Researchers at the Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a new potential target for drugs to prevent type 2 diabetes. A paper published today in the Journal of Clinical Investigation shows that blocking a cellular glucose sensor in muscle improves insulin responsiveness.

10 Aug 2016

Scientist receives $1.7 million grant to study how early life toxic exposures predispose to diabetes

Some studies indicate that early life exposure to pollutants such as PCBs and phthalates can predispose people to disease. Now environmental scientist Alicia Timme-Laragy at the University of Massachusetts Amherst has received a five-year, $1.7 million grant from the National Institute of Environmental Health Sciences for a multi-level study of early life exposure to environmental contaminants and aberrant pancreas development, which may predispose one to diabetes.

9 Aug 2016

Triple therapy approach helps Type 1 diabetes patients improve blood sugar control, lose weight

A combination of three medications—dapagliflozin, liraglutide and insulin—helped people with Type 1 diabetes improve blood sugar control and lose weight, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

5 Aug 2016

Review provides new insights into diagnosis, treatment for PCOS

Polycystic ovary syndrome (PCOS) afflicts over 14 million women in the United States. The disorder increases the risk of endometrial cancer, heart disease, high blood pressure, type 2 diabetes, asthma, obesity, depression and anxiety, as well as infertility and a variety of reproductive disorders.

4 Aug 2016

Scientists develop photosensitive mimics of class of signaling molecules

Teams at Ludwig-Maximilians-Universitaet in Munich and EMBL have created photosensitive mimics of a class of signaling molecules, thus enabling their actions to be regulated by light, and affording new insights into the communications networks that control cellular metabolism.

29 Jul 2016

New research collaboration aims to advance clinical trials of Cell Pouch System in people with type 1 diabetes

A new research funding agreement between the Juvenile Diabetes Research Foundation and Sernova, a clinical-stage regenerative medicine biotech, aims to address people with severe type 1 diabetes (T1D) who are hypoglycemia unaware, a condition in which a person with diabetes does not experience the usual early warning symptoms of hypoglycemia (low blood sugar) following an insulin injection.

26 Jul 2016

Study suggests failure of specialised beta cells may lead to diabetes

The significant role of beta cell 'hubs' in the pancreas has been demonstrated for the first time, suggesting that diabetes may due to the failure of a privileged few cells, rather than the behaviour of all cells.

21 Jul 2016

Risk of hypoglycemia differs between SU agents, study reveals

Adding sulphonylureas (SUs) to metformin remains a commonly used strategy for treating type 2 diabetes, but individual SUs differ and may confer different risks of abnormally low blood sugar, or hypoglycemia. SUs-which include newer generation agents such as gliclazide, glipizide, glimepiride, and glibenclamide-stimulate the production of insulin in the pancreas and increase the effectiveness of insulin in the body.

20 Jul 2016

Scientists identify marker that subdivides insulin-producing beta cells of the pancreas

The marker Flattop subdivides the insulin-producing beta cells of the pancreas into those that maintain glucose metabolism and into immature cells that divide more frequently and adapt to metabolic changes.

19 Jul 2016

Immunotherapy drug combination shows prominent therapeutic effect against advanced and metastatic cancers in mice

A drug combination designed to enhance the immune system's ability to zero in and attack cancer cells has shown a pronounced therapeutic effect against advanced and metastatic cancers in mice, according to a Mayo Clinic study, published in the July 12 edition of the online journal Oncotarget.

12 Jul 2016

Research on Flattop protein could provide starting point for regenerative diabetes therapies

12 Jul 2016

MGH researchers discover how obesity increases inflammation, desmoplasia in PDAC patients

Massachusetts General Hospital investigators have discovered the mechanism by which obesity increases inflammation and desmoplasia - an accumulation of connective tissue - in the most common form of pancreatic cancer.

7 Jul 2016

Liraglutide drug lowers blood sugar levels in diabetic patients taking large doses of insulin

When Amy Sweat was 19 years old, while she was in the hospital recovering from surgery, she was diagnosed with Type 2 diabetes. Ms. Sweat was treated for her diabetes, first on oral drugs, then on increasingly larger doses of insulin, but the years went by and she never was able to achieve good blood sugar control.

6 Jul 2016

MIT engineers develop new way to visualize RNA molecules in higher resolution

Cells contain thousands of messenger RNA molecules, which carry copies of DNA's genetic instructions to the rest of the cell. MIT engineers have now developed a way to visualize these molecules in higher resolution than previously possible in intact tissues, allowing researchers to precisely map the location of RNA throughout cells.

4 Jul 2016

Pancreas News and Research

Further Reading

Pancreatic cancer cells find alternative source of nutrition to avoid starvation

Diabetes mellitis coexisting with solid-organ malignancies linked to hospitalization risks

SBP researchers discover potential drug target for treatment of type 2 diabetes

Scientist receives $1.7 million grant to study how early life toxic exposures predispose to diabetes

Triple therapy approach helps Type 1 diabetes patients improve blood sugar control, lose weight

Review provides new insights into diagnosis, treatment for PCOS

Scientists develop photosensitive mimics of class of signaling molecules

New research collaboration aims to advance clinical trials of Cell Pouch System in people with type 1 diabetes

Study suggests failure of specialised beta cells may lead to diabetes

Risk of hypoglycemia differs between SU agents, study reveals

Scientists identify marker that subdivides insulin-producing beta cells of the pancreas

Immunotherapy drug combination shows prominent therapeutic effect against advanced and metastatic cancers in mice

Research on Flattop protein could provide starting point for regenerative diabetes therapies

MGH researchers discover how obesity increases inflammation, desmoplasia in PDAC patients

Liraglutide drug lowers blood sugar levels in diabetic patients taking large doses of insulin

MIT engineers develop new way to visualize RNA molecules in higher resolution

Immunotherapy in conjunction with drugs could be effective in treating pancreatic cancer

Study links proteins involved in cell division to insulin signaling

New study may help develop effective medication for severe pain

Appetite hormone CART helps increase insulin secretion, reduce glucagon production

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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