Genes News and Research

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Understanding how schizophrenia affects workings of the brain

Stem cells from adult schizophrenia patients form new proteins more slowly than those from healthy people, according to new research.

10 Nov 2015

UT Southwestern's Helen H. Hobbs named recipient of Breakthrough Prize in Life Sciences

UT Southwestern Medical Center geneticist Dr. Helen H. Hobbs is the 2016 recipient of the prestigious Breakthrough Prize in Life Sciences.

10 Nov 2015

AACR rapid and dramatic responses in TRK fusion patients

Loxo Oncology, Inc., a biopharmaceutical company innovating the development of highly selective medicines for patients with genetically defined cancers, today announced new results from its Phase 1 open-label, dose-escalation trial of LOXO-101, a selective inhibitor of tropomyosin receptor kinase (TRK) signaling molecules, and the first preclinical data for its RET and FGFR programs. The data are being presented at the 2015 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston.

9 Nov 2015

First comprehensive genomic and biologic study of top skin disease-causing microbes

An international team of scientists, led by researchers from A*STAR's Genome Institute of Singapore (GIS), Institute of Medical Biology (IMB), and Bioinformatics Institute (BII), and P&G, have completed the first comprehensive genomic and biologic study of all species of Malassezia, one of the top skin disease-causing microbes.

9 Nov 2015

Seven new nCounter PanCancer profiles launched to deeply probe cancer biology

NanoString Technologies, Inc.a provider of life science tools for translational research and molecular diagnostic products, today announced the expansion of its 3D Biology™ portfolio with the commercial launch of the nCounter® PanCancer Profiles, seven new gene expression panels each designed to interrogate a focused area of cancer biology including immuno-oncology.

9 Nov 2015

First male puberty timing study conducted

In the largest genomic analysis of puberty timing in men, new research conducted by scientists at the University of Cambridge and 23andMe* shows that the timing of puberty in males and females is influenced by many of the same-shared genetic factors. The study results are the first to quantify the strongly shared genetic basis for puberty timing between the sexes.

9 Nov 2015

Novel genetic therapy treats ‘incurable’ leukaemia

A new treatment that involves editing DNA has been used for the first time at Great Ormond Street Hospital to successfully treat drug-resistant leukaemia.

6 Nov 2015

Two genetic variants interact to alter the brain responses to high-calorie foods

For the first time, researchers have identified two genetic variants that interact to alter the brain responses to high-calorie foods, a tie that could aid in the development of targeted treatments for obesity and overweight. Researchers at Imperial College London led by Tony Goldstone, MD, PhD, of Consultant Endocrinologist, found that two gene variants - FTO and DRD2 - influenced activity in the brain reward system when looking at pictures of high-calorie foods.

6 Nov 2015

Researchers identify seven genetic risk loci involved in atopic march

There's a typical "career" for some allergic people, and it starts very early on the skin: babies develop atopic dermatitis, food allergies may follow, then comes asthma and later on hay fever. A group of scientists led by Ingo Marenholz and Young-Ae Lee at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, working with colleagues from several institutions, has now identified seven genetic risk loci for this course of disease.

6 Nov 2015

Scientists discover small molecule that can block growth of BRCA-deficient cancer cells

Cancer cells with mutations in BRCA1 or BRCA2 genes, which serve a vital role in preserving the integrity of the genetic code, are key targets for cancer therapeutics. Yet, few agents can selectively eliminate cells deficient in BRCA, and none can do so without the risk of inducing drug resistance.

6 Nov 2015

New tool could help identify patients most likely to benefit from chemoprevention

A team of scientists, led by researchers at University of California, San Diego Moores Cancer Center and The University of Texas MD Anderson Cancer Center, report that a genetic biomarker called loss of heterozygosity or LOH is able to predict which patients with premalignant mouth lesions are at highest risk of developing oral cancer.

6 Nov 2015

Genetic reduction of AMPK enzyme can prevent or delay hearing loss

A mitochondrial defect is responsible for a type of human hereditary deafness that worsens over time and can lead to profound hearing loss.

6 Nov 2015

University of Leicester awarded BBSRC grant to explore three key areas that impact human health

The University of Leicester has been awarded over £1.5 million in order to advance knowledge and understanding in three key areas that impact on health.

5 Nov 2015

Better understanding of hibernation could help researchers develop treatments for cardiac disease

Wintry weather means hats and scarves for some mammals, and hibernation for others. Hibernation dramatically lowers body temperatures, heart rates and oxygen consumption -- things that would be fatal to other animals. A team reports in ACS' Journal of Proteome Research a study of the proteins and genes that allow squirrels' hearts to stay healthy during the winter.

5 Nov 2015

Researchers find new way to prevent inflammation, accelerate the skin's healing process

Most products on the market today that are used to treat skin problems target the effects of the disease or wound such as inflammation, which can prolong the healing process and result in scarring. However, LSU Assistant Professor Wei Xu and collaborators at Northwestern University discovered a new way to prevent inflammation and to speed up the skin's healing process.

5 Nov 2015

Researchers identify mechanisms underlying postnatal organ maturation

Any expectant mother will tell you that she wants her baby's organs to develop properly in the womb. What she may not realize, however, is that a child's internal organs continue to develop for months and years after birth. This critical period is full of cellular changes that transform the organization and function of most tissues. But the exact mechanisms underlying postnatal organ maturation are still a mystery.

5 Nov 2015

Scientists create supercharged blood cell that may heal major wounds, block inflammation

Faculty of Medicine scientists have created a "Franken-platelet" - a supercharged blood cell - that might be capable of healing major wounds, busting clots or blocking inflammation.

5 Nov 2015

New research shows how food word cues can be linked with increased food desire and intake

New research shows that brain responses to written food words differ between lean individuals and those with obesity, and suggests that both stress and genetics could influence excess eating.

4 Nov 2015

Oxford professor wins Heinrich Wieland Prize for pioneering method that helps control nerve cells with light

Gero Miesenböck was the first to insert a light-controlled on/off switch into brain cells. His pioneering method allows scientists to switch nerve cells on and off selectively and observe how the behaviour of, for example, fruit flies or mice changes as a result. In this way, researchers can learn in a step-by-step process what behaviour the studied brain circuits control and what goes awry in disease. For his method, hailed as a "breakthrough of the decade," Professor Gero Miesenböck of the University of Oxford will receive the 100,000-euro Heinrich Wieland Prize of the Boehringer Ingelheim Foundation in Munich on November 6, 2015.

4 Nov 2015

Alnylam presents positive ongoing phase 2 open-label extension data for Patisiran and Revusiran

Alnylam Pharmaceuticals, Inc. has announced new results from its ongoing Phase 2 open-label extension (OLE) studies with patisiran and revusiran, investigational RNAi therapeutics targeting transthyretin (TTR) for the treatment of TTR-mediated amyloidosis (ATTR amyloidosis).

3 Nov 2015

Genes News and Research

Understanding how schizophrenia affects workings of the brain

UT Southwestern's Helen H. Hobbs named recipient of Breakthrough Prize in Life Sciences

AACR rapid and dramatic responses in TRK fusion patients

First comprehensive genomic and biologic study of top skin disease-causing microbes

Seven new nCounter PanCancer profiles launched to deeply probe cancer biology

First male puberty timing study conducted

Novel genetic therapy treats ‘incurable’ leukaemia

Two genetic variants interact to alter the brain responses to high-calorie foods

Researchers identify seven genetic risk loci involved in atopic march

Scientists discover small molecule that can block growth of BRCA-deficient cancer cells

New tool could help identify patients most likely to benefit from chemoprevention

Genetic reduction of AMPK enzyme can prevent or delay hearing loss

University of Leicester awarded BBSRC grant to explore three key areas that impact human health

Better understanding of hibernation could help researchers develop treatments for cardiac disease

Researchers find new way to prevent inflammation, accelerate the skin's healing process

Researchers identify mechanisms underlying postnatal organ maturation

Scientists create supercharged blood cell that may heal major wounds, block inflammation

New research shows how food word cues can be linked with increased food desire and intake

Oxford professor wins Heinrich Wieland Prize for pioneering method that helps control nerve cells with light

Alnylam presents positive ongoing phase 2 open-label extension data for Patisiran and Revusiran

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