New tool could help identify patients most likely to benefit from chemoprevention

NewsGuard 100/100 Score

A team of scientists, led by researchers at University of California, San Diego Moores Cancer Center and The University of Texas MD Anderson Cancer Center, report that a genetic biomarker called loss of heterozygosity or LOH is able to predict which patients with premalignant mouth lesions are at highest risk of developing oral cancer.

The findings, published in the November 5, 2015 online issue of Journal of the American Medical Association Oncology, present a new tool that could be used to identify patients most likely to benefit from chemoprevention -- and may be applicable to preventing other types of cancer.

More than 300,000 people are diagnosed with oral cancer worldwide each year, and 145,000 will die from this disease, which is the most common type of head and neck cancer.

"One of the greatest challenges in developing chemopreventive agents is to identify the population at highest cancer risk," said William N. William, Jr. MD, associate professor at MD Anderson, which led the enrollment and design of the study. "Not all patients with an oral premalignant lesion will develop oral cancer. By using a molecular test that can identify those at highest risk, we can focus preventive efforts on these specific individuals."

Erlotinib, marketed as Tarceva, is an inhibitor of the epidermal growth factor receptor (EGFR), a protein responsible for the development of many cancer types, including head and neck cancer. It is currently approved for the treatment of specific lung and pancreatic cancers and has shown promise in preventing oral cancer in animal models.

The Erlotinib Prevention of Oral Cancer (EPOC) trial involved 379 patients at five sites across the country. All had premalignant lesions in their mouths. Following study enrollment, participants were evaluated for LOH, a chromosomal abnormality characterized by the loss of chromosomal regions, which include tumor suppressor genes.

Patients who tested positive for LOH were considered to be at high risk for oral cancer and were randomized to receive either erlotinib or a placebo for one year. The study's primary endpoint was to determine if fewer patients treated with erlotinib would develop oral cancer, compared to those that received placebo.

"To the best of our knowledge, EPOC represents the first study of oral premalignant lesions to use cancer as the primary endpoint, and the first molecularly-based precision medicine trial design in cancer prevention," said Scott Lippman, MD, director of Moores Cancer Center at UC San Diego Health and senior author of the six-year study. The study began in 2006 when Lippman was chair of the Department of Thoracic/Head and Neck Medical Oncology at MD Anderson.

The EPOC study demonstrated that LOH predicted a higher oral cancer risk. LOH-negative patients had a three-year cancer-free survival rate of 87 percent compared to 74 percent for the LOH-positive group. However, patients who took erlotinib showed no statistical difference in terms of cancer-free survival rates after three years: 74 percent for participants given erlotinib compared to 70 percent for those taking placebo. Patients with both LOH and EGFR copy number gains had the highest incidence of cancer, but still did not benefit from erlotinib.

The lack of erlotinib benefit overall is disappointing, said Lippman, but still an important finding.

"It's vital to know what doesn't work as well as what does, and this research furthered progress in other ways," Lippman said. "For example, we demonstrated that erlotinib-treated patients who develop a skin rash, a common side effect of the drug, had the lowest incidence of oral cancer. Further investigations of this association could point to novel biomarkers, mechanisms and trial designs related to the effects of EGFR-targeted agents in patients with oral premalignant lesions or head and neck cancers."

Another key aspect of EPOC was the collection of blood and tissue samples throughout the study, which will now be used in follow-up research. William said further evaluation of the molecular underpinnings of these observations will hopefully lead to discovery of novel mechanisms of resistance and targets for personalized cancer prevention. MD Anderson was recently awarded a grant by the Cancer Prevention Research Institute of Texas to perform extensive molecular profiling of the EPOC specimens.


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Cancer researchers urged to embrace AI for groundbreaking insights and efficiency