Laboratory News and Research

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Researchers show how changes along lining of mammary ducts can lead to breast cancer

Breast cancer researchers have mapped early genetic alterations in normal-looking cells at various distances from primary tumors to show how changes along the lining of mammary ducts can lead to disease.

1 Nov 2017

PARP inhibitors may have efficacy in selected TNBC patients outside of germline BRCA mutation

The investigational PARP inhibitor talazoparib caused regression of patient-derived xenografts (PDXs) of triple-negative breast cancers (TNBC) that had BRCA mutations and also those that did not have BRCA mutations but had other alterations in DNA damage-repair pathways.

1 Nov 2017

Neutron crystallography study could open avenues for new drugs to battle diseases

Scientists at the Department of Energy’s Oak Ridge National Laboratory have performed neutron structural analysis of a vitamin B6-dependent protein, potentially opening avenues for new antibiotics and drugs to battle diseases such as drug-resistant tuberculosis, malaria, and diabetes.

1 Nov 2017

Historically ignored racial groups experience high rates of major health problems

Some of the smallest and historically neglected racial groups in the United States experience far more obesity, diabetes, and other health conditions than non-Hispanic white adults, a study by researchers at the University of California, Riverside has found.

1 Nov 2017

Our chromosomes also wrinkle with age, research shows

Grey hair, wisdom, and wrinkles on our skin mark us as we age, but it's the more subtle changes beneath the surface that make us old. Now, researchers have discovered that our chromosomes also wrinkle with age, changing how our immune system renews itself.

31 Oct 2017

Powerful toolkit uncovers rare tumor suppressor genes

A new statistical model has enabled researchers to pinpoint 27 novel genes thought to prevent cancer from forming, in an analysis of over 2000 tumors across 12 human cancer types. The findings could help create new cancer treatments that target these genes, and open up other avenues of cancer research.

31 Oct 2017

New device holds potential for early detection of cavities

Imagine if dentists could find clear signs of tooth decay long before dental lesions turn into cavities and without using X-rays. A new device cleared for commercialization this month by the Food and Drug Administration (FDA) is a potential tool for dentists to do just that.

30 Oct 2017

Study demonstrates beneficial effects of calorie-restricted diet in mice

Caloric restriction diets have been associated with various health benefits, but their effects on the skin have not been previously demonstrated. Research conducted at the University of São Paulo (USP) in Brazil shows that controlling calories helps mice live longer, although it reduces the reserves of fat in adipose tissue needed to keep the body warm.

30 Oct 2017

UTHealth professor receives $2.6 million NIH award for brain research

The National Institutes of Health has presented its Maximizing Investigators' Research Award to Vasanthi Jayaraman, Ph.D., a professor of biochemistry and molecular biology with McGovern Medical School at The University of Texas Health Science Center at Houston. It is a $2.6 million, five-year award.

30 Oct 2017

Using Machine Learning to Accurately Diagnose Childhood Autism Sooner

Autism is a clinical diagnosis. There is no one test to diagnose autism. Depending on the type of medical professional diagnosing, typically the DSM-V (standard classification of mental disorders used by mental health professionals in the U.S.) is used to diagnose by primary care physicians, neurologists, and psychiatrists.

30 Oct 2017

Inner workings of cells probed by new Kleindiek nanomanipulator at UNSW

The mechanism of how cells work is key to understanding how tumours metastasize as well as tissue regeneration and other bodily functions. The process of mechanotransduction, or how a cell converts a physical stimuli into an electrical response is fundamental to these understandings.

From AXT Pty Ltd 30 Oct 2017

Ameritox applauds President Trump’s declaration of opioid crisis as national public health emergency

Ameritox, a national leader in medication monitoring solutions for patients prescribed opioids and other medications for chronic pain and severe mental illness, today applauded the declaration of the opioid crisis as a national public health emergency by President Donald J. Trump.

30 Oct 2017

UC study reveals metamorphic adaptation of certain spadefoot toads in response to climate change

Deep within aquatic ecosystems all over the world, certain toad species have managed to survive warmer and drier climate change. But the method behind their metamorphic adaptation to environmental change over time has long puzzled scientists -- until now.

28 Oct 2017

Sonic Hedgehog helps solve mysteries of Parkinson's disease

You may know Sonic Hedgehog as a Sega videogame character who saves us all from world domination. But within the realm of science, Sonic Hedgehog is also helping to solve the mysteries of Parkinson's Disease.

28 Oct 2017

Cancer researchers make breakthrough in identifying genetic changes during immunotherapy

For some cancer patients, the road to remission and healing can have its share of speed bumps. That's particularly true of patients with non-small cell lung cancer (NSCLC) who develop a secondary, or acquired, resistance to immunotherapy, which initially was effective against their tumors.

28 Oct 2017

Longevity Biotech receives award to evaluate novel drug candidate for MS in preclinical models

Longevity Biotech, Inc. has received an award from the National Multiple Sclerosis Society through Fast Forward, the Society's commercial research funding program, to evaluate LBT-3627 in preclinical models as a potential disease-modifying therapeutic agent.

28 Oct 2017

Chinese scientists establish synthesis of promising compound to fight against pancreatic cancer

Intriguing antitumor activity is found in a very promising class of natural compounds: cyclic depsipeptides, which have a challenging structure that makes their investigation difficult. Now, Chinese scientists have established the synthesis of a member compound, which is especially promising in killing pancreatic cancer stem cells.

28 Oct 2017

Study characterizes hypertensive population with excess weight or obesity and sedentary habits

For the last seven years, researchers in the UPV/EHU's Department of Physical and Sports Education have been studying the hypertensive population with excess weight/obesity and sedentary habits. In a recent publication, this group has determined the state of health of this population through various key physical, physiological, clinical and nutritional markers and has separated them by sex and physical condition.

28 Oct 2017

Novel consortium aims to create new paradigm of cancer drug discovery

Scientists from two U.S. national laboratories, industry and academia today launched an unprecedented effort to transform the way cancer drugs are discovered by creating an open and sharable platform that integrates high-performance computing, shared biological data from public and industry sources and emerging biotechnologies to dramatically accelerate the discovery of effective cancer therapies.

27 Oct 2017

Novel laboratory model may shine light on development of pediatric high-grade glioma

Pediatric high-grade glioma is the primary cause of cancer death in children. Genesis of these tumors is believed to be driven by mutations in proteins that disrupt fundamental mechanisms governing the development of the human brain.

27 Oct 2017

Laboratory News and Research

Researchers show how changes along lining of mammary ducts can lead to breast cancer

PARP inhibitors may have efficacy in selected TNBC patients outside of germline BRCA mutation

Neutron crystallography study could open avenues for new drugs to battle diseases

Historically ignored racial groups experience high rates of major health problems

Our chromosomes also wrinkle with age, research shows

Powerful toolkit uncovers rare tumor suppressor genes

New device holds potential for early detection of cavities

Study demonstrates beneficial effects of calorie-restricted diet in mice

UTHealth professor receives $2.6 million NIH award for brain research

Using Machine Learning to Accurately Diagnose Childhood Autism Sooner

Inner workings of cells probed by new Kleindiek nanomanipulator at UNSW

Ameritox applauds President Trump’s declaration of opioid crisis as national public health emergency

UC study reveals metamorphic adaptation of certain spadefoot toads in response to climate change

Sonic Hedgehog helps solve mysteries of Parkinson's disease

Cancer researchers make breakthrough in identifying genetic changes during immunotherapy

Longevity Biotech receives award to evaluate novel drug candidate for MS in preclinical models

Chinese scientists establish synthesis of promising compound to fight against pancreatic cancer

Study characterizes hypertensive population with excess weight or obesity and sedentary habits

Novel consortium aims to create new paradigm of cancer drug discovery

Novel laboratory model may shine light on development of pediatric high-grade glioma

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