Mouse Model News and Research

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Will mRNA vaccine boosters be required for SARS-CoV-2 variants?

A new study shows that the highly effective mRNA Moderna vaccine designed against the original SARS-CoV-2 strain may lose some efficacy as new variants arise.

30 Aug 2021

Researchers test remotely operated implantable drug delivery devices on the ISS

From Novartis to Lamborghini, Alessandro Grattoni and the Houston Methodist Research Institute have partnered with big names to leverage the International Space Station U.S. National Laboratory for space-based research and technology development with important benefits back on Earth.

28 Aug 2021

'Humanized' mouse model beats current approaches for finding the best organ donor

A "humanized" mouse model equipped with the immune system of a patient who needs an organ transplant beats current measures for identifying the best potential living donor, scientists report.

27 Aug 2021

Brain organoids provide a valuable model to study autism

Variations in the 16p11.2 region of the genome are associated with autism spectrum disorder. While people with genetic deletions in this region have larger heads (macrocephaly) and people with genetic duplications have smaller heads (microcephaly), both variation types affect brain development and function.

26 Aug 2021

Study suggests a novel therapeutic target to reverse lung fibrosis

Researchers have reversed lung fibrosis in a mouse model of idiopathic pulmonary fibrosis, or IPF, as reported in a study published in the journal Cell Death and Differentiation.

24 Aug 2021

New mouse model may help elucidate the pathogenic mechanisms behind Sjögren's syndrome

Sjögren's syndrome is an autoimmune disease that attacks the tear system in the eyes and salivary glands, leading to patients experiencing extremely dry eyes and mouth.

23 Aug 2021

Preclinical study validates crucial role of the spleen in cardiac repair

Although we can survive without a spleen, evidence continues to mount that this abdominal organ plays a more valuable role in our physiological defenses than previously suspected.

23 Aug 2021

Study investigates the effects of calycosin on breast cancer cell progression

Aging-US published "Calycosin inhibits breast cancer cell migration and invasion by suppressing EMT via BATF/TGF-β1" which reported that in this study, the authors investigated the effects of calycosin on breast cancer cell progression and their underlying mechanisms. Calycosin dose- and time-dependently inhibited proliferation, migration, and invasion by T47D and MCF-7 breast cancer cells by downregulating basic leucine zipper ATF-like transcription factor expression.

23 Aug 2021

Human milk oligosaccharides may help treat or prevent bacterial infections in newborns and adults

Bacteria known as group B Streptococcus (GBS) are a common cause of blood infections, meningitis and stillbirth in newborns. Although GBS infections can often be treated or prevented with antibiotics, the bacteria are becoming increasingly resistant.

23 Aug 2021

Regular physical exercise modulates iron metabolism in Alzheimer’s mouse model

A recent experimental study shows how regular physical exercise modulates iron metabolism in both the brain and the muscles.

20 Aug 2021

Studies shed light on the versatility, precision, and sensitivity of quantitative analytical tools

Three independent studies in the Journal of Pharmaceutical Analysis explore the potential uses and applications of quantitative analytical tools in the characterization and quality assessment of biological and medicinal compounds.

19 Aug 2021

Scientists identify the main components driving amyloid beta-associated synapse degeneration

Healthy adult brains are endowed with a vast number of synapses, structures that relay signals across nerve cells to enable communications, information processing and storage throughout the nervous system.

18 Aug 2021

Study illuminates the link between cholesterol and Alzheimer's-associated toxic protein clumps

A team co-led by scientists at Scripps Research has used advanced imaging methods to reveal how the production of the Alzheimer's-associated protein amyloid beta (Aβ) in the brain is tightly regulated by cholesterol.

13 Aug 2021

Discovery of highly potent neutralizing monoclonal antibodies against SARS-CoV-2

A new study published in the journal Nature Communications has reported two neutralizing antibodies, namely, nCoVmab1 and nCoVmab2, which are potent against SARS-CoV-2.

13 Aug 2021

Study finds novel approach to attenuate mitochondrial dysfunction that drives diet-induced obesity

A team of University of California, Irvine, scientists have discovered a novel pharmacological approach to attenuate the mitochondrial dysfunction that drives diet-induced obesity.

12 Aug 2021

Understanding hypoxia-induced gene expression variations in aggressive type of pancreatic cancer

Cancer cells have evolved a myriad of mechanisms that support their uncontrolled growth. In case of solid tissue tumors, the tumor microenvironment, which consists of extracellular components and conditions surrounding the tumor, is crucial in deciding the fate of the cancer cells.

11 Aug 2021

Mouse Model News and Research

Will mRNA vaccine boosters be required for SARS-CoV-2 variants?

Researchers test remotely operated implantable drug delivery devices on the ISS

'Humanized' mouse model beats current approaches for finding the best organ donor

Brain organoids provide a valuable model to study autism

Study suggests a novel therapeutic target to reverse lung fibrosis

New mouse model may help elucidate the pathogenic mechanisms behind Sjögren's syndrome

Preclinical study validates crucial role of the spleen in cardiac repair

Study investigates the effects of calycosin on breast cancer cell progression

Human milk oligosaccharides may help treat or prevent bacterial infections in newborns and adults

Regular physical exercise modulates iron metabolism in Alzheimer’s mouse model

Studies shed light on the versatility, precision, and sensitivity of quantitative analytical tools

Scientists identify the main components driving amyloid beta-associated synapse degeneration

Study illuminates the link between cholesterol and Alzheimer's-associated toxic protein clumps

Discovery of highly potent neutralizing monoclonal antibodies against SARS-CoV-2

Study finds novel approach to attenuate mitochondrial dysfunction that drives diet-induced obesity

Understanding hypoxia-induced gene expression variations in aggressive type of pancreatic cancer

Study defines SARS-CoV-2 antibodies associated with neutralization and effector functions

Study shows efficacy of gamma irradiation of SARS-CoV-2 vaccine candidate in mouse model

Potential new treatment for mast cell cancers reduces tumor size and prevents organ infiltration

Study identifies Foxo1 gene as a potential treatment target for hereditary lymphedema

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