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SARS-CoV-2 is evolving adaptively in multiple regions of the genome

Scientists from the United States have recently assessed the evolutionary success of mutations accumulated across severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome. They have observed that the positively-selected mutations in the viral spike S1 subunit are primarily responsible for adaptive evolution. This indicates that the virus may undergo antigenic drift.

23 Mar 2022

Niacin limits Alzheimer's disease progression in animal model

Indiana University School of Medicine researchers found that niacin limits Alzheimer's disease progression when used in models in the lab, a discovery that could potentially pave the way toward therapeutic approaches to the disease.

23 Mar 2022

New therapy makes immunologically 'cold' tumors hot enough for immune attack

Pancreatic cancer is notoriously difficult to cure or even treat. Now, a new strategy devised by scientists at Albert Einstein College of Medicine has succeeded in making pancreatic tumors visible to the immune systems of mice and vulnerable to immune attack, reducing cancer metastases by 87%.

23 Mar 2022

Scientists develop first drug to treat uncontrolled secretion of mucins in the airways

A multicenter research team co-led by The University of Texas MD Anderson Cancer Center developed the first drug to treat the uncontrolled secretion of mucins in the airways, which causes potentially life-threatening symptoms in millions of Americans with asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF), as well as lung disease resulting from cancer and cancer treatment.

23 Mar 2022

Origins of Type 2 diabetes differ between males and females, research shows

Over the past four decades, global cases of Type 2 diabetes mellitus have skyrocketed. According to the World Health Organization, the number of people estimated to have the disease jumped from 108 million in 1980 to 422 million in 2014, with the fastest growth observed in low- and middle-income countries.

23 Mar 2022

Biomarker testing in lung cancer patients has increased in real-world clinical practice, study reveals

More than half of patients diagnosed with advanced non-small cell lung cancer (NSCLC) undergo biomarker testing, and this figure has increased over the last five years, reveal real-world data from a Spanish national registry study reported at the European Lung Cancer Congress, 30 March-2 April 2022.

23 Mar 2022

Predicting the risk of some common diseases in preimplantation fertilized embryos

A new study uses a novel strategy for whole-genome reconstruction by using parental genome sequencing and sibling embryo genotyping.

23 Mar 2022

T-cell and neutralizing antibody response after a third COVID-19 vaccine dose in hemodialysis patients

Researchers compare the impact of a third mRNA COVID-19 vaccine in hemodialysis patients by measuring antibody levels and IFN-γ responses.

23 Mar 2022

Researchers investigate Galectin-9 as a new treatment target for COVID-19

Researchers discuss alternate therapeutic targets for treating COVID-19 and the effects of Gal-9 on SARS-CoV-2 infection and the immune response.

23 Mar 2022

Study confirms no preexisting B-cell immunity against SARS-CoV-2 in pre-pandemic samples

A recent study finds that there is no considerable B-cell immunity against SARS-CoV-2 in unexposed healthy individuals.

23 Mar 2022

New nanoparticle-based COVID-19 vaccine platform could target other infectious diseases

Just one dose of a new nanoparticle-based COVID-19 vaccine was enough to produce an immune response in animals on track with vaccines currently in clinical use.

23 Mar 2022

Researchers identify microbial cooperation as one of the causes of drug tolerance

The treatment of fungal infections is often hampered by fungal pathogens that do not respond, or are tolerant, against anti-fungal drugs.

23 Mar 2022

TTUHSC researcher secures $1.9 million grant to investigate vulnerabilities in ALT cancers

The National Cancer Institute, part of the National Institutes of Health, recently awarded a five-year, $ $1.9 million grant to C. Patrick Reynolds, M.D., Ph.D., director for the School of Medicine Cancer Center at the Texas Tech University Health Sciences Center.

23 Mar 2022

Monoclonal antibodies found to prevent lung inflammation in SARS-CoV-2-Omicron-infected mice

Researchers investigated how monoclonal antibodies, S309 and AZD7442, reduced lung infection in mice infected with the SARS-CoV-2 new variant of concern Omicron's BA.1, BA.1.1, and BA.2 sublineages.

23 Mar 2022

People who consume sugar for extended periods have increased risk of autoimmune disease

People who consume sugar and other carbohydrates in excess over a long period of time have an increased risk of developing an autoimmune disease.

23 Mar 2022

Study discovers potent and selective human monoclonal antibodies against Omicron variant of SARS-CoV-2

In a new study, researchers discovered human monoclonal antibodies, which were specific and potent against the severe acute respiratory syndrome coronavirus 2 Omicron variant.

23 Mar 2022

Novel monoclonal antibody found to have substantial neutralizing capacity against SARS-CoV-2 Omicron variant

Researchers reported a new monoclonal antibody, P2G3, which significantly neutralized the SARS-CoV-2 Omicron variant.

23 Mar 2022

Study investigates germinal center of antibody-mediated immunity against SARS-CoV-2

In a new study, researchers explored the germinal center of antibody-mediated immunity towards SARS-CoV-2.

23 Mar 2022

Study reveals new opportunities for using small molecule drugs to target KRAS mutants

Research published today in Nature Chemical Biology reveals new opportunities for using small molecule drugs to target KRAS, the most commonly mutated protein in cancer.

23 Mar 2022

New York Blood Center and Columbia University partner to advance the use of mRNA technology in HIV vaccine study

New York Blood Center’s Project ACHIEVE and Columbia University’s Columbia Research Unit are working in partnership for the New York City effort to advance the use of messenger ribonucleic acid (mRNA) technology in an HIV preventive vaccine study – HVTN 302.

23 Mar 2022

Cell News and Research

SARS-CoV-2 is evolving adaptively in multiple regions of the genome

Niacin limits Alzheimer's disease progression in animal model

New therapy makes immunologically 'cold' tumors hot enough for immune attack

Scientists develop first drug to treat uncontrolled secretion of mucins in the airways

Origins of Type 2 diabetes differ between males and females, research shows

Biomarker testing in lung cancer patients has increased in real-world clinical practice, study reveals

Predicting the risk of some common diseases in preimplantation fertilized embryos

T-cell and neutralizing antibody response after a third COVID-19 vaccine dose in hemodialysis patients

Researchers investigate Galectin-9 as a new treatment target for COVID-19

Study confirms no preexisting B-cell immunity against SARS-CoV-2 in pre-pandemic samples

New nanoparticle-based COVID-19 vaccine platform could target other infectious diseases

Researchers identify microbial cooperation as one of the causes of drug tolerance

TTUHSC researcher secures $1.9 million grant to investigate vulnerabilities in ALT cancers

Monoclonal antibodies found to prevent lung inflammation in SARS-CoV-2-Omicron-infected mice

People who consume sugar for extended periods have increased risk of autoimmune disease

Study discovers potent and selective human monoclonal antibodies against Omicron variant of SARS-CoV-2

Novel monoclonal antibody found to have substantial neutralizing capacity against SARS-CoV-2 Omicron variant

Study investigates germinal center of antibody-mediated immunity against SARS-CoV-2

Study reveals new opportunities for using small molecule drugs to target KRAS mutants

New York Blood Center and Columbia University partner to advance the use of mRNA technology in HIV vaccine study

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