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Theracurmin shows positive impact on human diastolic functions

The research group led by Dr. Koji Hasegawa, Director of the Translational Research Division at the National Hospital Organization Kyoto Medical Center and Dr. Tatsuya Morimoto, Professor at the Molecular Medicine School of Pharmaceutical Sciences, University of Shizuoka, announced today based on the recent human clinical trials, that Theracurmin has continuously shown positive impact on human diastolic functions.

26 Mar 2012

Promising results from Esperion ETC-1002 Phase 2 clinical trial for dyslipidemia

Esperion Therapeutics, a privately held biotechnology company working to discover, develop and commercialize treatments for cardiovascular and metabolic diseases, today announced positive results from a Phase 2 clinical trial for ETC-1002.

26 Mar 2012

Commensal bacteria may play an important role in influencing and controlling allergic inflammation

When poet Walt Whitman wrote that we "contain multitudes," he was speaking metaphorically, but he was correct in the literal sense. Every human being carries over 100 trillion individual bacterial cells within the intestine -- ten times more cells than comprise the body itself.

26 Mar 2012

S. gordonii may trigger infective endocarditis

Oral bacteria that escape into the bloodstream are able to cause blood clots and trigger life-threatening endocarditis. Further research could lead to new drugs to tackle infective heart disease, say scientists presenting their work at the Society for General Microbiology's Spring Conference in Dublin this week.

26 Mar 2012

New IVIG trial can reduce OCD symptoms in children with PANDAS

Criteria for a broadened syndrome of acute onset obsessive compulsive disorder (OCD) have been proposed by a National Institutes of Health scientist and her colleagues. The syndrome, Pediatric Acute-onset Neuropsychiatric Syndrome (PANS), includes children and teens that suddenly develop on-again/off-again OCD symptoms or abnormal eating behaviors, along with other psychiatric symptoms - without any known cause.

26 Mar 2012

Alcohol linked to 25% increase in liver disease deaths

The first report from the fledgling National End of Life Care Intelligence Network warns that the victims of liver disease are getting younger, with deaths increasing among people in their forties. Deaths rose from 9,231 in 2001 to 11,575 in 2009; some 60% of these were men, and 90% of them were under 70. Deaths are more common in England's northern regions marked by high unemployment and low educational achievement.

25 Mar 2012

Heart attack may soon be predicted by a simple blood test

Researchers have found a simple test that could predict whether a patient is about to have a heart attack. They used a blood sample to detect cells that have sloughed off of damaged blood vessel walls to predict a heart attack.

25 Mar 2012

Investigators identify proteins that may indicate fetus at risk for UTI-induced prematurity

Investigators in The Research Institute at Nationwide Children's Hospital have developed a mouse model in which a mother's urinary tract infection negatively affects the offspring, an occurrence anecdotally observed in humans. Using this first-of-its-kind model, they have identified proteins in the blood that may indicate whether such an infection might stunt fetal growth.

23 Mar 2012

Immediate skull reconstruction aggravates brain damage in TBI model

Immediate skull reconstruction following trauma that penetrates or creates an indentation in the skull can aggravate brain damage inflicted by the initial injury, a study by a University of South Florida research team reports.

23 Mar 2012

GUCY2C gene mutation leads to familial diarrhea syndrome

When the intestines are not able to properly process our diet, a variety of disorders can develop, with chronic diarrhea as a common symptom. Chronic diarrhea can also be inherited, most commonly through conditions with genetic components such as irritable bowel syndrome. Researchers in Norway, India, and at the HudsonAlpha Institute for Biotechnology have identified one heritable DNA mutation that leads to chronic diarrhea and bowel inflammation.

22 Mar 2012

Pannexins may contribute to symptoms related to IBD

Researchers from the Hotchkiss Brain Institute (HBI) and the Snyder Institute for Chronic Diseases at the University of Calgary's Faculty of Medicine have discovered a pathway that may contribute to the symptoms related to Crohn's disease and ulcerative colitis, collectively known as Inflammatory Bowel Disease.

22 Mar 2012

Study finds higher death rate in calorie-restricted models of IBD

In a surprising result, Michigan State University researchers looking at the effects of diet on bowel disease found that mice on a calorie-restricted diet were more likely to die after being infected with an inflammation-causing bacterial pathogen in the colon.

21 Mar 2012

State-level resources may contribute to risk of heart disease in women

According to new research from Brigham and Women's Hospital (BWH), a state's level of wealth or poverty is linked with levels of cardiovascular inflammation in women.

21 Mar 2012

Elevated Aβ peptide levels may lead to onset of AD

The effects of the bacterial endotoxin lipopolysaccharide (LPS) has been found to elevate amyloid beta (Aβ) peptide levels in the brain, leading to short-term deficits in learning.

21 Mar 2012

BPA alters uterus structure leading to potentially fatal infection

Researchers at the University of Cincinnati (UC) have found evidence that, in addition to affecting the heart, brain and nervous system, bisphenol A (BPA), could affect a mammal's ability to reproduce by altering the structure of the uterus in ways that can progress to a potentially fatal infection.

21 Mar 2012

Factors that increase the possibility of having migraines

A migraine is the most common type of headache that propels patients to seek care from their doctors. Roughly 30 million Americans suffer from migraine headaches, with women affected almost three times more often than men, according to statistics from the National Headache Foundation in Chicago.

21 Mar 2012

IDSA releases new rhinosinusitis guidelines

The vast majority of sinus infections are caused by viruses and should not be treated with antibiotics, suggest new guidelines released by the Infectious Diseases Society of America.

21 Mar 2012

Study identifies function of GlialCAM gene in brain edema

A study of the pathophysiology of this rare disease has uncovered one mechanism that destabilizes the homeostatic balance of brain cells causing edema.

20 Mar 2012

Hedgehog and mTOR pathway are active in esophageal cancer

Identification of a non-traditional pathway for spiriting a cancer-promoting protein into the cell nucleus points to a possible combination therapy for esophageal cancer and indicates a mechanism of resistance for new drugs that attack the Hedgehog pathway.

20 Mar 2012

Disruptions in immune system regulation may play a role in NEC

Despite advances in neonatal care, necrotizing enterocolitis (NEC) - the most common gastrointestinal emergency in premature infants - continues to be a deadly disease. "We haven't made a lot of progress in identifying babies early who may be at risk for NEC, preventing it or treating it," said J-rn-Hendrik Weitkamp, M.D., a neonatologist and assistant professor of Pediatrics at Monroe Carell Jr. Children's Hospital at Vanderbilt.

20 Mar 2012