BCG Vaccine News and Research

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The BCG Vaccine is a vaccine containing bacillus Calmette-Guerin (BCG), an attenuated strain of Mycobacterium bovis, with non-specific immunoadjuvant and immunotherapeutic activities. Although the mechanism of its anti-tumor activity is unclear, immunization with BCG vaccine likely activates a Th1 cytokine response that includes the induction of interferon. Vaccination with BCG vaccine may be immunoprotective against infection with Mycobacterium tuberculosis.

New tuberculosis vaccine effective in animal testing

A new tuberculosis vaccine candidate developed by researchers at Canada's McMaster University has proven effective in animal testing, the researchers announced Thursday, the Hamilton Spectator reports.

23 Mar 2009

Breakthrough improves effectiveness of tuberculosis vaccine

A breakthrough strategy to improve the effectiveness of the only tuberculosis vaccine approved for humans provided superior protection against the deadly disease in a pre-clinical test, report scientists at The University of Texas Health Science Center at Houston in Nature Medicine 's Advance Online Publication March 1.

8 Mar 2009

Tuberculosis breakthrough could lead to stronger vaccine

3 Mar 2009

New discovery improves efficacy of current tuberculosis vaccine

A new article appearing in the March 2009 issue of the Journal of Leukocyte Biology may lead to improvements in the efficacy of the current tuberculosis vaccine.

26 Feb 2009

100,000 saved from dying of tuberculosis

Asma Elsony led the tuberculosis programme in Sudan at the same time as she took her doctoral degree under the supervision of Professor Gunnar Bjune of the Department of General Practice and Community Medicine, University of Oslo in Norway.

13 Nov 2008

New tuberculosis vaccine safer, more effective than BCG vaccine for HIV-positive people

A new tuberculosis vaccine could be safer and more effective than the currently available BCG vaccine, particularly for HIV-positive people, according to a study to be published in the November issue of Infection and Immunity, IANS/Times of India reports (IANS/Times of India, 10/24).

28 Oct 2008

Better TB vaccine in the pipeline

Scientists in the U.S. believe they have a vaccine in the pipeline that offers better protection from tuberculosis (TB).

20 Oct 2008

A new inhaled TB vaccine

A new tuberculosis vaccine successfully tested at the University of North Carolina at Chapel Hill is easier to administer and store and just as effective as one commonly used worldwide.

17 Mar 2008

MGH initiates trial to reverse type 1 diabetes

Scientists at the Massachusetts General Hospital (MGH) have initiated a phase 1 clinical trial to reverse type 1 diabetes.

14 Mar 2008

Aerosol vaccine provides low-cost, needle-free TB treatment

A novel aerosol version of the most common tuberculosis (TB) vaccine, administered directly to the lungs as an oral mist, offers significantly better protection against the disease in experimental animals than a comparable dose of the traditional injected vaccine, researchers report this week in the Proceedings of the National Academy of Sciences.

13 Mar 2008

BCG vaccine causing illness, death among HIV-positive infants, report says

The BCG vaccine, which aims to prevent tuberculosis among children in developing countries, might be causing illness and death among some HIV-positive infants, researchers said on Friday, the Los Angeles Times reports.

6 Nov 2007

TB vaccine can be a killer for babies with HIV

Experts in South Africa say a vaccine which was meant to protect children in developing countries from tuberculosis (TB)may in fact be killing them.

4 Nov 2007

Prototype vaccine against tuberculosis

Using a novel approach, researchers at the Albert Einstein College of Medicine of Yeshiva University have developed a prototype vaccine against tuberculosis (TB) that works better in animal models than the only TB vaccine now available.

2 Aug 2007

New TB vaccine could save over a million lives

Initial trials of a new tuberculosis (TB) vaccine mean the drug will now progress to phase II trials.

31 Jul 2007

New TB vaccines could protect all strains

New tuberculosis (TB) vaccines in development have the potential to provide protection against all strains of TB, including multidrug-resistant (MDR) and extensively drug- resistant (XDR) TB, Dr. Jerald C.

1 Jun 2007

Novel spray method for delivering tuberculosis vaccine

Bioengineers and public health researchers at Harvard University have developed a novel spraying method for delivering the most common tuberculosis (TB) vaccine, providing a new low-cost and scaleable technique that offers needle-free delivery and greater stability at room temperature than existing methods.

18 Feb 2007

CCR5 receptor discovery could help fight against tuberculosis, HIV

A key aspect of how the body kicks the immune system into action against tuberculosis is revealed in research published today.

20 Oct 2006

The incidence, distribution, and control of tuberculosis

A reduction in tuberculosis (TB) incidence, prevalence and death rate can be achieved by 2015 in most parts of the world, with the greatest challenges occurring in Africa and Eastern Europe, according to a projection by the Stop TB Department of the World Health Organization.

1 Mar 2006

Bacille Calmette Guerin (BCG) vaccination can protect children from tuberculosis infection as well as active TB disease

There are about 10 million cases of TB globally each year and 1 in 3 people are infected with the TB bacterium. BCG is the most widely used vaccine worldwide, but its mechanism of protection is poorly understood. It is thought to prevent progression of infection to active TB but whether it protects against the acquisition of infection itself has not been investigated in humans.

13 Oct 2005

Stopping UK BCG vaccination well justified

From autumn 2005, the long running routine programme to vaccinate school children against tuberculosis with BCG vaccine will stop. This decision brings the UK into line with much of the rest of the world and is well justified, writes Professor Paul Fine in the British Medical Journal (BMJ).

26 Sep 2005