Crystallography News and Research

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New insight into SARS-CoV-2 nsp14 protein opens door to new drugs

In a recent research paper currently available on bioRxiv* preprint server, scientists from the University of Oxford in the United Kingdom and the University of Auckland in New Zealand identified several structural specificities of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may serve as viable starting points for the development and optimization of viral inhibitors against coronavirus disease 2019 (COVID-19) and other future threats.

16 Mar 2022

Spectacular structure of C.difficile's protective armor revealed

The spectacular structure of the protective armor of superbug C.difficile has been revealed for the first time showing the close-knit yet flexible outer layer – like chain mail.

25 Feb 2022

Novel glycation patterns help understand Omicron immune escape

A new study explores changes in the sugar structure of the SARS-CoV-2 Omicron variant, which may shed light on its immunologic escape and transmissibility characteristics.

15 Feb 2022

Molecular cage helps researchers to get atomic-level details of key cancer protein

Acute myeloid leukemia (AML), the American Cancer Institute estimates, will affect more than 20,000 Americans this year and kill more than 11,000 of them.

11 Feb 2022

Illustrating the structural diversity of SARS-CoV-2 Omicron spike

In a new study, a team of researchers used cryo-electron microscopy to determine the spike (S) structures of the SARS-CoV-2 Omicron variant to understand how the mutations that alter its primary sequence impact S conformation.

1 Feb 2022

Structural proteomics approaches can help in the treatment of neurodegenerative diseases

Two researchers from Skoltech and McGill University have published a review of the promising research field known as structural proteomics in the influential journal Chemical Reviews.

27 Jan 2022

Effects of the Omicron spike amino acid changes in the interaction with human ACE2 receptor or human antibodies

A recent study analyzed the effects of the interaction between SARS-CoV-2 Omicron spike amino acid and the human ACE2 receptor or with human antibodies.

26 Jan 2022

Scientists explore how proteins bind with specific companions inside cells

Despite its minute size, a single cell contains billions of molecules that bustle around and bind to one another, carrying out vital functions. The human genome encodes about 20,000 proteins, most of which interact with partner proteins to mediate upwards of 400,000 distinct interactions.

25 Jan 2022

Topical antiseptic Acriflavine inhibits SARS-CoV-2 and other betacoronaviruses

A new study, published in the journal Cell Chemical Biology, has reported the discovery of acriflavine (ACF), an effective inhibitor of SARS-CoV-2. This drug is a mixture of trypaflavines (3,6-diamino-10-methylacridinium chloride and 3,6-diamino-3-methylacridinium chloride) and proflavine (3,6-diaminoacridine).

16 Jan 2022

Study shows that key parts of human immunity are shared in bacteria

The human immune system, that marvel of complexity, subtlety, and sophistication, includes a billion-year-old family of proteins used by bacteria to defend themselves against viruses, scientists at Dana-Farber Cancer Institute and in Israel have discovered.

13 Jan 2022

Scientists provide a structural framework for Omicron immune evasion and ACE2 receptor recognition

An interesting preprint research paper describes structural changes resulting from the multiple mutations found in the recent Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is the causative agent behind the coronavirus disease 2019 (COVID-19) pandemic. In addition, the research describes the consequent effects of these changes on Omicron’s infectivity and immune evasion capabilities.

5 Jan 2022

Boceprevir-based molecules show high antiviral potency against SARS-CoV-2

In a study posted to the bioRxiv* pre-print server, a team of researchers conducted a structure-activity relationship study of boceprevir-based molecules to find antiviral drug candidates targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protease MPro.

22 Dec 2021

Study reveals how a protein in the blood is attracted to key component of Adenovirus-based vaccines

A collaborative team from the School of Medicine at the University of Cardiff, Wales and a range of US institutions used the UK's national synchrotron, Diamond Light Source, to help reveal the details of how a protein in the blood is attracted to a key component of Adenovirus based vaccines.

8 Dec 2021

Crystallography News and Research

New insight into SARS-CoV-2 nsp14 protein opens door to new drugs

Spectacular structure of C.difficile's protective armor revealed

Novel glycation patterns help understand Omicron immune escape

Molecular cage helps researchers to get atomic-level details of key cancer protein

Illustrating the structural diversity of SARS-CoV-2 Omicron spike

Structural proteomics approaches can help in the treatment of neurodegenerative diseases

Effects of the Omicron spike amino acid changes in the interaction with human ACE2 receptor or human antibodies

Scientists explore how proteins bind with specific companions inside cells

Topical antiseptic Acriflavine inhibits SARS-CoV-2 and other betacoronaviruses

Study shows that key parts of human immunity are shared in bacteria

Scientists provide a structural framework for Omicron immune evasion and ACE2 receptor recognition

Boceprevir-based molecules show high antiviral potency against SARS-CoV-2

Study reveals how a protein in the blood is attracted to key component of Adenovirus-based vaccines

Structure-guided virtual screening identifies novel SARS-CoV-2 Mpro inhibitors

Isolation of potent neutralizing monoclonal antibodies using nanoparticles displaying SARS-CoV-2 S glycoprotein

Structural and molecular contributions to understanding antibody recognition of pathogenic viruses

New method reveals changes in protein structure more efficiently and accurately than before

New computer-aided data tool could improve treatment for many diseases

New method to study the nuclear pore complex directly inside cells

Research elucidates how chaperones display "selective promiscuity" for specific proteins

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