Induced Pluripotent Stem Cells News and Research

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Upper airway model derived from iPSCs paves the way for broader studies of viral lung infections

A team led by researchers at Newcastle University, UK has successfully created a model of the cells found in the lungs that can be used to replicate how COVID-19 infects the airways.

21 Jun 2021

Researchers study what happens in brain cells affected by Alzheimer's disease

Studies on tissue from patients and mini-brains made from stem cells shed light on the disease.

14 Jun 2021

SBP scientist receives $1.9 million from NHLBI for atrial fibrillation research

Sanford Burnham Prebys Assistant Professor Alexandre Colas has been awarded $1.9 million by the National Heart, Lung, and Blood Institute at the National Institutes of Health to discover drugs that restore normal cardiac rhythm in atrial fibrillation.

14 Jun 2021

Researchers identify a common mechanism underlying diverse brain disorders

Researchers at Vanderbilt University Medical Center have identified a common mechanism underlying a spectrum of epilepsy syndromes and neurodevelopmental disorders, including autism, that are caused by variations in a gene encoding a vital transporter protein in the brain.

9 Jun 2021

Tiny implant reverses diabetes in mice without requiring drugs

A team of researchers led by diabetes specialists and biomedical engineers at Washington University School of Medicine in St. Louis and Cornell University has demonstrated that, using a miniscule device, they can implant insulin-secreting cells into diabetic mice.

3 Jun 2021

Blocking TGFβ1 could improve hematopoiesis in AML patients, indicates study

Bone marrow failure due to acute myeloid leukemia (AML) is a significant factor behind the disease's high rate of morbidity and mortality. Previous studies in mice suggest that AML cells inhibit healthy hematopoietic (blood) stem and progenitor cells (HSPC).

20 May 2021

Machine learning approach helps study human hypothalamus at the single-cell level

Human brain organoids are remarkable platforms for modeling features of human brain development and diseases.

11 May 2021

Four-part small-molecule cocktail can prevent cellular stress

Researchers at the National Institutes of Health (NIH) have devised a four-part small-molecule cocktail that can protect stem cells called induced pluripotent stem cells (iPSCs) from stress and maintain normal stem cell structure and function.

4 May 2021

Tiny 3D brain models could accelerate drug research for multiple sclerosis

Tiny 3-D models that mimic vital aspects of the human nervous system have been developed in a step that could accelerate drug research for neurological conditions such as multiple sclerosis (MS).

3 May 2021

New gene therapy restores dystrophin protein in patients with Duchenne muscular dystrophy

UT Southwestern scientists successfully employed a new type of gene therapy to treat mice with Duchenne muscular dystrophy (DMD), uniquely utilizing CRISPR-Cas9-based tools to restore a large section of the dystrophin protein that is missing in many DMD patients.

3 May 2021

Recreating early embryos using stem cells

In their effort to understand the very earliest stages of life and how they can go wrong, scientists are confronted with ethical issues surrounding the use of human embryos.

23 Apr 2021

New miniaturized model of neuromuscular junction formation provides insight into ALS

Skeletal muscles enable voluntary movements and are controlled by a special type of neurons called motor neurons, which make direct contact with skeletal muscles through so-called neuromuscular junctions (NMJs).

22 Apr 2021

Stem cell therapy can repair brain damage and improve memory function in mice

A one-time injection of an experimental stem cell therapy can repair brain damage and improve memory function in mice with conditions that replicate human strokes and dementia, a new UCLA study finds.

21 Apr 2021

MIPT and Harvard researchers grow and transplant retinal ganglion cells to treat glaucoma

A joint research carried out by MIPT scientists and Harvard researchers have presented retinal cells that can integrate into the retina.

19 Apr 2021

Aged bone marrow niche restrains function of rejuvenated HSCs, shows study

When leukemia strikes an older person, it is in part due to the aging of his or her hematopoietic stem cells (HSCs).

13 Apr 2021

New RNA-sequencing method can help detect numerous modified small RNAs

A team led by a biomedical scientist at the University of California, Riverside, has developed a new RNA-sequencing method-- "Panoramic RNA Display by Overcoming RNA Modification Aborted Sequencing," or PANDORA-seq -- that can help discover numerous modified small RNAs that were previously undetectable.

5 Apr 2021

Stem cell therapy could help restore debilitating age-related muscle loss

As the name implies, induced pluripotent stem cells can become any type of cell in our body, and scientists have evidence that when they prompt them to become muscle progenitor cells they can help restore the sometimes debilitating muscle loss that happens with age.

23 Mar 2021

Researcher uses alternative approach to find genetic drivers of rare eye disease

An analysis of thousands of genomes from people with and without the rare eye disease known as MacTel has turned up more than a dozen gene variants that are likely causing the condition to develop and worsen for a significant share of patients.

23 Mar 2021

NYSCF is developing new stem cell therapy to treat age-related macular degeneration

The New York Stem Cell Foundation (NYSCF) today announced that they are developing a stem cell therapy to treat patients suffering from age-related macular degeneration (AMD).

22 Mar 2021

Novel technology may reveal the brain's mysteries

A team of scientists, led by researchers at Northwestern University, Shirley Ryan AbilityLab and the University of Illinois at Chicago (UIC), has developed novel technology promising to increase understanding of how brains develop, and offer answers on repairing brains in the wake of neurotrauma and neurodegenerative diseases.

22 Mar 2021