Ketamine News and Research

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Mount Sinai researchers review progress made in using ketamine and other therapies to treat depression

Major depressive disorder (MDD) impacts 15 million Americans and is the leading cause of disability, yet current treatments possess limited efficacy.

17 Mar 2017

New study offers insights into how antidepressants work in the brain

When they work, antidepressant medications may take weeks or months to alleviate symptoms of depression.

2 Feb 2017

Alcohol produces same neural and molecular changes as rapid antidepressant drugs

Can having a few drinks help people with clinical depression feel better? Yes. At least in terms of biochemistry.

28 Sep 2016

CHOP researchers exploit gene discovery in severe epilepsy to identify precision treatment

An international team of researchers who discovered a new gene disorder that causes severe childhood epilepsy leveraged that finding to reduce seizures in two children.

20 Sep 2016

Anaesthetic known for surgical procedures may be quick remedy for depression

Vienna and MedUni Vienna are currently the hotspot for brain health: this coming Thursday, the very first "Brain Day" will be held for a lay audience in the Van Swieten Hall of the Medical University of Vienna.

12 Sep 2016

Component of general anesthetic shows improvement in patients with treatment-resistant depression

A new study in Biological Psychiatry reports that esketamine, a component of the general anesthetic ketamine, shows rapid and significant improvement in depressive symptoms in patients who do not respond to currently available therapies.

8 Sep 2016

Patients undergoing breast cancer surgery with non-opiate anaesthesia may need less painkillers

New research presented at Euroanaesthesia 2016 shows that patients undergoing breast cancer surgery need less painkilling medication post-surgery if they have anaesthesia that is free of opioid drugs.

31 May 2016

Scientists find ketamine as effective sedative for treating highly-agitated patients prior to hospitalisation

Scientists have shown that ketamine is far more effective than the more commonly used haloperidol for treating highly-agitated patients prior to hospitalisation.

23 May 2016

Understanding potential of illicit drug ketamine in treating depression

Advancing the understanding and treatment of psychiatric disorders is a principal goal of neuroscientists. As mental disorders are the leading cause of disabilities worldwide, it is concerning that there are few effective therapeutics on the market due to the lack of knowledge regarding pathophysiology.

19 May 2016

Mouse model of depression can help better understand how ketamine functions

New research demonstrates the effectiveness of ketamine to treat depression in a mouse model of the disease and brings together two hypotheses for the cause of depression.

19 May 2016

Study explores neurological mechanisms in action during ketamine anesthesia

It's a topic that has long captivated doctors, scientists and the public — what exactly happens in your brain when you're oblivious on the operating table?

12 May 2016

Repeat, low-dose ketamine infusions may quickly reduce suicidal thoughts in depressed outpatients

Repeat intravenous treatment with low doses of the anesthetic drug ketamine quickly reduced suicidal thoughts in a small group of patients with treatment-resistant depression.

11 May 2016

Research shows how recreational ketamine abuse harms the bladder

Research conducted by scientists at the University of York has revealed how recreational ketamine abuse damages the bladder

21 Mar 2016

Ketamine appears to be safe, effective for difficult-to-sedate ER patients

For the small segment of the emergency population whose acute behavioral disturbance does not respond to traditional sedation, ketamine appears to be effective and safe, according to an Australian study published online last Thursday in Annals of Emergency Medicine ("Ketamine for Difficult to Sedate Severe Acute Behavioral Disturbance in the Emergency Department").

25 Feb 2016

Vanderbilt study offers a glimmer of hope to alcoholics suffering from depression

A study by researchers at Vanderbilt University Medical Center is offering a glimmer of hope to alcoholics who find it hard to remain sober because their abstinence is hounded by stubborn, difficult-to-treat depression.

1 Feb 2016

Rapastinel demonstrates pro-cognitive benefits in animal model of cognitive impairment

Allergan plc, a leading global pharmaceutical company, announced today that new data on the investigational medication rapastinel (GLYX-13) and its lack of impairment on cognitive function were published in the peer-reviewed journal Behavioural Brain Research.

19 Jan 2016

Inflammation associated with elevated glutamate in the brain could guide depression treatments

Psychiatrists investigating depression have been energized in recent years by reports of rapid, successful treatment with drugs that interfere with the brain chemical glutamate, such as the anesthetic ketamine.

13 Jan 2016

CGP3466B compound may effectively treat depression

The compound CGP3466B, already proven nontoxic for people, may effectively and rapidly treat depression, according to results of a study in mice.

13 Jan 2016

Yale researchers reveal why chronic overeating tied to increased risk of depression

Chronic overeating and stress are tied to an increased risk of depression and anxiety, and in a new study, Yale researchers explain why that happens and suggest a possible solution.

22 Dec 2015

Turing Pharmaceuticals emphasizes continued availability of Daraprim

Turing Pharmaceuticals AG, a privately-held biopharmaceutical company focused on developing and commercializing innovative treatments for serious diseases and conditions, today emphasizes the continued availability of Daraprim and cautions healthcare providers of proposed alternatives to Daraprim.

20 Dec 2015