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AMG 133 (maridebart cafraglutide) weight loss drug shows promise in early trial

AMG 133, an engineered bispecific molecule, demonstrated significant weight loss with a favorable safety profile in a phase 1 clinical trial, offering a promising new treatment option for obesity.

7 Feb 2024

Novel macrolide- DEL-1 axis helps in bone regeneration and new bone formation

Periodontitis is characterized by the loss of teeth resulting from inflammation of gums due to bacterial infections.

24 Jan 2024

Study uncovers 23 new genetic markers linked to kidney health on the X-chromosome

A meta-analysis of 908,697 samples to investigate the genetic, sex-dependent basis of kidney traits.

23 Jan 2024

Increased milk intake associated with a decreased risk of type 2 diabetes in adults who do not produce lactase

The researchers of a recent study published in Nature Metabolism investigated the relationship between milk consumption and type 2 diabetes among lactase non-persistent individuals.

22 Jan 2024

Study identifies more than 200 new genes linked to depression

More than 200 genes linked to depression have been newly identified in a worldwide study led by UCL researchers.

10 Jan 2024

Largest genetic study of gestational diabetes discovers nine novel genetic regions linked to severe and common pregnancy complication

Researchers investigated the genetic underpinnings of Gestational Diabetes Mellitus (GDM) and its relationship with Type 2 Diabetes (T2D) through a genome-wide association study ((GWAS), identifying distinct and shared genetic factors.

9 Jan 2024

Genetic clue to pericarditis inflammation points to promising new treatments

Sequence variants that protect against pericarditis have been discovered at a genomic locus encoding interleukin-1 immune cytokines.

27 Dec 2023

Fetal hormone GDF15 linked to nausea and vomiting in pregnancy

Study finds that high levels of the fetal hormone GDF15 in mothers are linked to an increased risk of nausea, vomiting, and hyperemesis gravidarum in pregnancy, offering new insights into the condition's etiology.

14 Dec 2023

New genetic links to coronary artery calcification uncovered, offering treatment insights

A study in Nature Cardiovascular Research identifies two new genetic loci associated with coronary artery calcification (CAC), a key indicator of atherosclerosis and coronary artery disease.

5 Dec 2023

Researchers introduce CRISPR-mediated genome and cancer shredding as a conceptual paradigm to treat recurrent gliomas

Researchers demonstrated clustered regularly interspersed short palindromic repeats (CRISPR)-mediated elimination of glioblastoma (GBM) cells.

29 Nov 2023

Genome study unveils genetic ties between cannabis use disorder and lung cancer risk

A genome-wide association study in Nature Genetics reveals insights into the genetics of cannabis use disorder, highlighting its strong association with psychopathology and a causal link to lung cancer, and suggesting distinct genetic pathways from mere cannabis use.

23 Nov 2023

Genetic vulnerability of leukemia cells uncovered

Leukemia is the most common type of cancer in children. Treatment involves intensive chemotherapy, which has severe side effects due to its non-specific mode of action.

22 Nov 2023

New study links DNA methylation in GLP1R gene to obesity without metabolic disorders

The study investigates the role of epigenetic changes in GLP1R gene polymorphisms on metabolically healthy obesity (MHO), revealing that apart from genetic variations, DNA methylation significantly influences the occurrence of MHO.

20 Nov 2023

Stem-cell-derived brain cells hold promise for Alzheimer's, Parkinson's research

Researchers at the University of Wisconsin–Madison have identified a protein key to the development of a type of brain cell believed to play a role in disorders like Alzheimer's and Parkinson's diseases and used the discovery to grow the neurons from stem cells for the first time.

17 Nov 2023

New diagnostic workflow improves detection of 5q-spinal muscular atrophy

5q-spinal muscular atrophy (5q-SMA) is one of the more common types of spinal muscular atrophy (SMA) affecting around one in ten thousand individuals worldwide.

15 Nov 2023

Genetic melting pot: Study unveils complex admixture in European ancestry populations

In a recent Nature Communications study, researchers revealed that Europeans and European Americans possess a significant subcontinental genetic admixture, challenging the notion that these populations are homogenous. This finding suggests the need to re-evaluate genetic epidemiology studies that may have overlooked the influence of admixture on disease associations and trait heritability in these groups.

8 Nov 2023

Locus News and Research

AMG 133 (maridebart cafraglutide) weight loss drug shows promise in early trial

Novel macrolide- DEL-1 axis helps in bone regeneration and new bone formation

Study uncovers 23 new genetic markers linked to kidney health on the X-chromosome

Increased milk intake associated with a decreased risk of type 2 diabetes in adults who do not produce lactase

Study identifies more than 200 new genes linked to depression

Largest genetic study of gestational diabetes discovers nine novel genetic regions linked to severe and common pregnancy complication

Genetic clue to pericarditis inflammation points to promising new treatments

Fetal hormone GDF15 linked to nausea and vomiting in pregnancy

New genetic links to coronary artery calcification uncovered, offering treatment insights

Researchers introduce CRISPR-mediated genome and cancer shredding as a conceptual paradigm to treat recurrent gliomas

Genome study unveils genetic ties between cannabis use disorder and lung cancer risk

Genetic vulnerability of leukemia cells uncovered

New study links DNA methylation in GLP1R gene to obesity without metabolic disorders

Stem-cell-derived brain cells hold promise for Alzheimer's, Parkinson's research

New diagnostic workflow improves detection of 5q-spinal muscular atrophy

Genetic melting pot: Study unveils complex admixture in European ancestry populations

Pharmacogenomics holds promise for personalized dementia therapies

Genetic twist in gallstone disease may shield against heart attacks

Science, Innovation, and Xenotransplantation: A Discussion with Dr. Wenning Qin

Proof-of-concept study holds promise for safer gene therapy techniques for treating immunodeficiencies

Industry Focus eBook - Cell biology (5th edition) eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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