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Transition Therapeutics presents Phase 2 study of ELND005 drug for bipolar disorder

Transition Therapeutics Inc. ("Transition" or the "Company") today announced findings from a Phase 2 study of neuropsychiatric drug candidate, ELND005, as an adjunctive maintenance treatment for bipolar disorder type I patients (BPD).

4 Nov 2014

Verbal abuse worsens bipolar disease outcome

Experiencing verbal abuse in childhood has a lasting negative effect on the course of bipolar disorder, researchers have found.

22 Oct 2014

UMMS, UMMSM researchers identify key genetic pathway underlying bipolar disorder

A team of scientists led by researchers at the University of Massachusetts Medical School and the University of Miami Miller School of Medicine have identified what is likely a key genetic pathway underlying bipolar (manic depressive) disorder, a breakthrough that could lead to better drugs for treating bipolar affective disorder, as well as depression and other related mood disorders.

14 Oct 2014

Clinical pointers to bipolar, unipolar depression confirmed

A large study confirms several factors that can distinguish patients with bipolar depression from those with unipolar depression, including higher trait impulsivity, aggression and hostility.

10 Oct 2014

Clinical practice study supports ISBD recommendations

Findings in patients with bipolar disorder given short-term antidepressant treatment support the recent International Society for Bipolar Disorder’s task force recommendations.

2 Oct 2014

Weight cycling linked to relapse-prone bipolar course

Patients with bipolar disorder are more likely than healthy controls to have a history of weight cycling, which in turn is associated with an increased likelihood of manic and depressive episodes, researchers report.

25 Sep 2014

Benefits and risks of hatha yoga for people with bipolar disorder

Right now no one can say whether yoga provides clinical benefits to people with bipolar disorder, but in a new article in the Journal of Psychiatric Practice, researchers report survey responses they gathered from scores of people with the condition who practice yoga. What the collective testimony suggests is that yoga can be a substantial help, but it sometimes carries risks, too.

18 Sep 2014

Cyclothymic temperament linked to suicidality

The presence of a cyclothymic temperament in inpatients with bipolar disorder may indicate a high likelihood of hopelessness and suicidality, report researchers.

17 Sep 2014

FDA approves Contrave extended-release tablets for chronic weight management

Takeda Pharmaceuticals U.S.A., Inc. and Orexigen® Therapeutics, Inc. jointly announced today that the U.S. Food and Drug Administration has approved Contrave® extended-release tablets as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index of 30 kg/m2 or greater (obese), or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition.

11 Sep 2014

Optimal personalised treatment improves bipolar life quality, functioning

Optimal personalised treatment improves quality of life and functioning of patients with bipolar disorder type I or II, suggests research published in the Journal of Affective Disorders.

28 Aug 2014

Aberrant reward processing likely to precede bipolar symptom onset

Healthy children who have a parent with bipolar disorder show altered brain activation during reward processing, research shows.

28 Aug 2014

Earlier treatment better for bipolar patients

Patients with bipolar disorder are more likely to respond to lithium if the treatment is started early in the course of the condition, say researchers.

24 Jul 2014

Viewpoints: Parsing newest reports of coverage gains; 'scientific fraudsters'

It will take a while to understand fully how the Affordable Care Act affects the quality of health care and access to doctors in this country.

14 Jul 2014

Factors linked to bipolar cycle acceleration identified

Researchers have identified factors that are associated with cycle acceleration in patients with bipolar disorder admitted to hospital for a mood episode.

3 Jul 2014

Researchers identify genetic mutation that may cause parkinsonism in young people

Researchers at the University of Copenhagen and the Copenhagen University Hospital have identified a particular genetic mutation that may cause parkinsonism in young people. The mutation interferes with the brain's transport of the important signal substance dopamine and may also plays a role in mental diseases, e.g. ADHD.

3 Jul 2014

Antidepressant risk in bipolar patients limited to monotherapy use

Antidepressants may cause problems in patients with bipolar disorder only when they are used in isolation, research suggests.

26 Jun 2014

DBS improves motor and non motor symptoms of patients with early Parkinson's disease

Deep brain stimulation (DBS) has become a well-recognized non-pharmacologic treatment that improves motor symptoms of patients with early and advanced Parkinson's disease.

26 Jun 2014

Depression 5 times common in people with bipolar disorder who have low levels of cortisol

Depression is almost twice as common, and poor quality of life almost five times as common, in people with bipolar disorder who have elevated or low levels of the stress hormone cortisol in the blood.

19 Jun 2014

Johns Hopkins to host 5th annual Graphic Medicine Conference

The Johns Hopkins University School of Medicine’s Department of Art as Applied to Medicine is hosting the fifth annual Graphic Medicine Conference, to take place June 26 to June 28 in the Preclinical Teaching Building on the Johns Hopkins medical campus.

17 Jun 2014

Predictive factors ‘raise suspicion’ for emergence of bipolar disorder

Researchers have identified seven factors that predict which patients initially diagnosed with depression will later meet the diagnostic criteria for bipolar disorder.

5 Jun 2014