Pathophysiology News and Research

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Scientists uncover how herpes virus fuels Alzheimer’s disease

Herpesvirus infection may contribute to Alzheimer’s disease through transposable element activation and neuroinflammation.

2 Mar 2025

Understanding the impact of SLC transporters on liver disease progression

Hepatic steatosis, often triggered by non-alcoholic fatty liver disease (NAFLD), is a leading cause of liver dysfunction globally, affecting approximately 30% of the population.

28 Feb 2025

Artificial sweeteners may reduce metformin’s effectiveness in weight and glucose control

Drinking artificially sweetened beverages may reduce metformin’s effectiveness in young patients with obesity and prediabetes, but a larger study is needed to confirm these findings.

27 Feb 2025

Venom is everywhere: Study examines hidden toxin delivery systems across life forms

Forget snakes and spiders—a new review details venomous plants, fungi, and even bacteria, proving that nature's deadliest secret weapon is more widespread than we ever imagined.

23 Feb 2025

Targeting FGFR mutations offers new hope for bone repair in skeletal disorders

Gain-of-function mutations in fibroblast growth factor receptor (FGFR) genes are known to cause a range of skeletal disorders, such as craniosynostosis and chondrodysplasia, which severely affect craniofacial and mandibular development.

21 Feb 2025

Genetic mutation linked to schizophrenia in both humans and mice

A genetic mutation found in two human patients with schizophrenia also increased schizophrenia-related behaviors in mice with the same mutation, a rare finding of a direct genetic link to psychosis, report researchers at the University of Illinois Urbana-Champaign and colleagues in Massachusetts and Germany.

19 Feb 2025

New study reveals LRP1's crucial role in bone formation and joint development

Skeletal conditions such as developmental dysplasia of the hip (DDH), osteoporosis, and osteoarthritis affect millions worldwide, often causing chronic pain and disability. These disorders stem from complex genetic and environmental interactions that disrupt bone formation and joint development.

19 Feb 2025

Targeting PAK5 could offer new therapeutic approach for endometriosis

Endometriosis, a prevalent gynecological condition, is characterized by the growth of endometrial-like tissues outside the uterus, leading to severe pain and infertility in affected women.

11 Feb 2025

Study links low levels of PM2.5 exposure to liver damage

Researchers examine the liver toxicity of low levels of PM2.5 exposure.

5 Feb 2025

Innovative 3D blood-brain barrier model enhances understanding of neuroinflammation

A 3D model accurately mimicking the Blood-Brain Barrier (BBB) in a laboratory environment has been successfully developed by research teams led by Professor Jinah Jang from the Departments of Mechanical Engineering, Life Sciences, IT Convergence Engineering, and the Graduate School of Convergence at POSTECH, and Professor Sun Ha Paek from the Department of Neurosurgery at Seoul National University Hospital.

3 Feb 2025

New targeted therapy could bring relief to people with lichen planus

Mayo Clinic researchers have identified a targeted therapy that could bring relief to people living with lichen planus, a chronic inflammatory skin condition of the skin, hair, nails, mouth and genitals.

3 Feb 2025

Prolonged REM sleep latency linked to Alzheimer’s disease biomarkers

Research indicates longer REM latency is associated with higher Alzheimer's biomarkers, pointing to its potential as an early indicator of neurodegeneration.

29 Jan 2025

Exercise improves brain insulin sensitivity and lowers dementia risk in older adults with prediabetes

Researchers explore the impact of exercise on the short-term regulation of insulin pathways in brain circuits.

28 Jan 2025

Study uncovers distinct blood protein signature in children with Long COVID

Distinct protein profiles linked to inflammation and angiogenesis found in children with Long COVID, paving the way for improved diagnostics and therapies.

28 Jan 2025

Decades of DNA expansion linked to Huntington’s disease neurodegeneration

Researchers uncover how slow CAG repeat expansions in neurons drive Huntington’s disease over decades.

24 Jan 2025

Researchers identify ferroptosis as driver of osteocyte death in melanoma metastasis

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain.

23 Jan 2025

New imaging protocol enhances visualization of rare bone marrow cells

Bone marrow plays a crucial role in maintaining hematopoietic stem cells and bone homeostasis. However, research has been hindered by a lack of effective markers and monoclonal antibodies to accurately identify rare LepR+ stromal cells.

21 Jan 2025

How lifestyle-based interventions help manage PCOS

Studies indicate that lifestyle modifications can alleviate PCOS symptoms, improving insulin resistance and hormonal balance through diet and physical activity.

21 Jan 2025

Retinal vascular features identified as potential predictors of stroke risk

Researchers identify how specific features of the retinal vasculature may help predict an individual’s risk of stroke.

20 Jan 2025

New rabbit model provides insights into CF-related pancreatic endocrine pathology

Cystic fibrosis (CF) is a life-threatening genetic disease affecting multiple organ systems, with pancreatic dysfunction representing a critical and often overlooked complication.

17 Jan 2025