Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Scientists map regulatory landscape of mouse genome at single-cell resolution

Scientists have completed a major effort to map the regulatory landscape of the mouse genome at a single-cell resolution.

2 Aug 2018

Pioneering research takes major step forward in the fight against cystic fibrosis

The fight against cystic fibrosis has taken a major step forward, with pioneering research by University of Adelaide scientists showing that cells causing the debilitating genetic disorder could be successfully replaced with healthy ones.

2 Aug 2018

Breakthrough in stem cell research could lead to cure for cystic fibrosis

Researchers have successfully proved that gene therapy can be used to convert adult stem cells into functioning lung cells for the treatment of cystic fibrosis

2 Aug 2018

3D-printed implants appear to guide regrowth of missing bone in lab animals

Chemically coated, ceramic implants successfully guided the regrowth of missing bone in lab animals while "steadily dissolving," researchers report.

2 Aug 2018

Microscopic imaging helps better understand cancer bone metastasis

Scientists at The University of Texas MD Anderson Cancer Center have engineered a system allowing microscopic monitoring and imaging of cancer that has spread to the bone in mice so they can better understand and develop treatment for bone metastasis in humans.

2 Aug 2018

Scientists find people's assumptions about DNA repair after CRISPR editing to be wrong

Despite high hopes and high investment in CRISPR-Cas9 gene editing, scientists still have a lot to learn about how it works in humans.

31 Jul 2018

FDA approves first therapy for patients with rare tumors of the adrenal gland

The U.S. Food and Drug Administration today approved Azedra (iobenguane I 131) injection for intravenous use for the treatment of adults and adolescents age 12 and older with rare tumors of the adrenal gland (pheochromocytoma or paraganglioma) that cannot be surgically removed (unresectable), have spread beyond the original tumor site and require systemic anticancer therapy.

31 Jul 2018

Ivosidenib receives FDA approval to treat acute myeloid leukemia patients with IDH1 mutation

Clinical trials at University of Colorado Cancer Center and elsewhere now result in the drug ivosidenib earning approval from the U.S. Food and Drug Administration for the treatment of adult patients with relapsed or refractory acute myeloid leukemia with a susceptible isocitrate dehydrogenase-1 mutation.

30 Jul 2018

New improved mouse model could revolutionize bone metastasis research

Researchers at Tokyo Institute of Technology propose an improved mouse model that could revolutionize bone metastasis research. Their method, which involves injecting cancer cells via the so-called caudal artery in the mouse tail, overcomes many limitations of traditional mouse models.

30 Jul 2018

Beckman Coulter introduces expanded range of clinical flow cytometry solutions at AACC 2018

Beckman Coulter continues to expand portfolio of clinical flow cytometry solutions with its latest innovations.

From Beckman Coulter Life Sciences - Flow Cytometry 30 Jul 2018

Janssen’s Darzalex receives positive CHMP opinion for treating multiple myeloma patients

The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended broadening the existing marketing authorization for Darzalex® for use as frontline therapy.

28 Jul 2018

Answer to decades-old mystery may allow some children to avoid bone marrow transplantation

Researchers have helped solve a decades-old mystery about which mutations are responsible for an inherited bone marrow disorder.

27 Jul 2018

Study reveals key role of actin cytoskeletal dynamics in supporting immune cell function

In order to move, a body needs a strong scaffold. This is not only true on a macroscopic level, where animals rely on skeletons to support their muscles.

26 Jul 2018

'Hijacked' cell response to stress reveals potential therapeutic targets for leukemia

A signaling pathway that helps promote normal cell growth worsens a form of leukemia by taking control of another pathway better known for protecting cells from biological stress, a new study shows.

24 Jul 2018

Pfizer announces FDA approval of biosimilar to Neupogen

Pfizer Inc. today announced that the United States Food and Drug Administration has approved NIVESTYM (filgrastim-aafi), a biosimilar to Neupogen (filgrastim), for all eligible indications of the reference product.

23 Jul 2018

FDA approves first drug for treatment of adult AML patients with specific genetic mutation

The U.S. Food and Drug Administration today approved Tibsovo (ivosidenib) tablets for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) who have a specific genetic mutation.

20 Jul 2018

AbbVie submits supplemental NDA to FDA for venetoclax to treat acute myeloid leukemia

AbbVie, a research-based global biopharmaceutical company, today announced it submitted a supplemental New Drug Application to the U.S. Food and Drug Administration for venetoclax in combination with a hypomethylating agent or in combination with low-dose cytarabine for the treatment of newly diagnosed patients with acute myeloid leukemia who are ineligible for intensive chemotherapy.

20 Jul 2018

Researchers unravel how ALL invades the central nervous system

A deadly feature of acute lymphoblastic leukemia is its invasion of the central nervous system.

19 Jul 2018

CT scans may raise brain tumor risk

A new study in the Journal of the National Cancer Institute suggests that CT scans, commonly used in medical imaging, may increase the risk of brain tumors.

18 Jul 2018

Homogenous BTK occupancy assay used in tirabrutinib clinical studies

In a new SLAS Discovery article, Helen Yu and a team of researchers at Gilead Sciences, Inc. present a time-resolved fluorescence resonance energy transfer-based Bruton's tyrosine kinase occupancy assay that can measure target engagement in peripheral blood mononuclear cells and in lymph-node and bone-marrow samples.

17 Jul 2018

Bone Marrow News and Research

Further Reading

Scientists map regulatory landscape of mouse genome at single-cell resolution

Pioneering research takes major step forward in the fight against cystic fibrosis

Breakthrough in stem cell research could lead to cure for cystic fibrosis

3D-printed implants appear to guide regrowth of missing bone in lab animals

Microscopic imaging helps better understand cancer bone metastasis

Scientists find people's assumptions about DNA repair after CRISPR editing to be wrong

FDA approves first therapy for patients with rare tumors of the adrenal gland

Ivosidenib receives FDA approval to treat acute myeloid leukemia patients with IDH1 mutation

New improved mouse model could revolutionize bone metastasis research

Beckman Coulter introduces expanded range of clinical flow cytometry solutions at AACC 2018

Janssen’s Darzalex receives positive CHMP opinion for treating multiple myeloma patients

Answer to decades-old mystery may allow some children to avoid bone marrow transplantation

Study reveals key role of actin cytoskeletal dynamics in supporting immune cell function

'Hijacked' cell response to stress reveals potential therapeutic targets for leukemia

Pfizer announces FDA approval of biosimilar to Neupogen

FDA approves first drug for treatment of adult AML patients with specific genetic mutation

AbbVie submits supplemental NDA to FDA for venetoclax to treat acute myeloid leukemia

Researchers unravel how ALL invades the central nervous system

CT scans may raise brain tumor risk

Homogenous BTK occupancy assay used in tirabrutinib clinical studies

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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