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Model simulations show no need for DEX dose adjustments in COVID-19 patients with liver disease

A recent study sed PBPK modeling to demonstrate the use of DEX PKs for the treatment of COVID-19 in patients with liver impairment.

17 Nov 2021

Raising awareness of stroke and how to prevent it

In this interview, we speak to Dr. Patrick Brouwer, the head of worldwide medical affairs for CERENOVUS, about stroke and how to prevent it.

From CERENOVUS 17 Nov 2021

Commonly prescribed anticoagulants may increase UTI severity

New research by the Centenary Institute suggests that commonly prescribed anticoagulants – medicines, such as aspirin, that help prevent blood clots – may make urinary tract infections (UTIs) more severe.

17 Nov 2021

Study finds lower-quality thrombectomy outcomes for Hispanic ischemic stroke patients

A study involving UT Southwestern neurology researchers found lower-quality outcomes for Hispanic ischemic stroke patients who receive endovascular thrombectomies than for comparable white and Black patients.

17 Nov 2021

New imaging software can accurately diagnose jaundice in the blink of an eye

Imagine a system that can detect within one second whether a newborn baby has jaundice, a condition affecting 60 per cent of infants, and in severe cases leading to brain damage and hearing loss.

17 Nov 2021

Urinary SARS-CoV-2 RNA is a prognosticator of COVID-19

A new study published in the journal Diagnostics was based on the hypothesis that detecting urinary SARS-CoV-2 nucleic acid––which may result in renal and cardiovascular endothelial destruction to facilitate viral access to the kidney parenchyma—may be used as a specific biomarker to indicate the severity of COVID-19.

16 Nov 2021

Tighter blood pressure management may lead to better spinal cord injury recovery

Patients with new spinal cord injuries whose blood pressure is maintained within a newly defined range during surgery may stand a better chance of regaining some mobility and functionality – even in patients with the most devastating injuries – according to a new study by researchers at UC San Francisco.

16 Nov 2021

Scientists identify new gene that contributes to type 1 diabetes progression

When the pro-inflammatory pair, a receptor called CCR2 and its ligand CCL-2, get together, it increases the risk of developing type 1 diabetes, scientists report.

16 Nov 2021

Tricuspid-valve repair during mitral-valve surgery may benefit some patients

An international study of more than 400 adults concludes that people who undergo mitral valve surgery (between the left atrium and the left ventricle of the heart) and also have less than severe leakage of the tricuspid valve (a section of the heart that directs blood from the right atrium to the ventricle) may benefit from having both valves repaired at the same time.

16 Nov 2021

COVID-19 booster shot extremely beneficial for most cancer patients

Most cancer patients who had no measurable immune response after being fully vaccinated for COVID-19 were helped by a third vaccine dose, according to a new study by investigators at the Montefiore Einstein Cancer Center.

16 Nov 2021

New research finds disturbing lack of crucial blood cancer medication

New research in the November 2021 issue of JNCCN - Journal of the National Comprehensive Cancer Network finds fewer than one-third of hospitals had immediate availability of a crucial blood cancer medication called all-trans retinoic acid (ATRA).

16 Nov 2021

Study: Covid-19 vaccine-elicited immune cells persist six months after vaccination

A recent study by Johns Hopkins Medicine researchers provides evidence that CD4+ T lymphocytes — immune system cells also known as helper T cells — produced by people who received either of the two available messenger RNA (mRNA) vaccines for COVID-19 persist six months after vaccination at only slightly reduced levels from two weeks after vaccination and are at significantly higher levels than for those who are unvaccinated.

16 Nov 2021

Drug improved cardiac structure and function in patients with early-stage hypertrophic cardiomyopathy

Valsartan, an angiotensin II receptor blocker drug, delayed disease progression and improved cardiac structure and function in patients with early-stage hypertrophic cardiomyopathy, according to results from a recent clinical trial published in Nature Medicine.

16 Nov 2021

Elderly residents of long-term care facilities benefit from booster vaccines against SARS-CoV-2

A recent study investigates whether markers of cellular and humoral immunity differ between adults over 75 and a control group six months after vaccination.

16 Nov 2021

SARS-CoV-2 replicates in human placenta with release of infectious viral particles

The current study analyzed the interaction of SARS-CoV-2 at the human maternal-fetal interface by using an advanced ex vivo model.

16 Nov 2021

Lesser sodium and higher potassium intake associated with lower cardiovascular disease risk

Lower sodium consumption and higher potassium intake is linked with lower risk of cardiovascular disease (CVD) in most people, according to a study led by Harvard T.H. Chan School of Public Health researchers.

16 Nov 2021

Myocarditis among Moderna COVID-19 vaccine recipients

A new preprint reports on the incidence of myocarditis in a large population of over 150 million who received two doses of the first vaccine to receive emergency use authorization against the virus.

16 Nov 2021

Rapid finger stick test to detect antibodies against SARS-CoV-2 variants

A new preprint reports a semi-quantitative test that can measure neutralizing antibodies to the SARS-CoV-2 pathogen at the point of care, using a finger stick or venipuncture blood.

16 Nov 2021

Study analyzes association between obesity and endothelial dysfunction in COVID-19 patients

In COVID-19 patients, obesity is the factor most associated with the development of endothelial dysfunction, a condition in which the blood vessels become unable to contract and relax adequately, increasing the risk of events such as heart attacks, thrombosis (blood clotting), and stroke.

15 Nov 2021

Researchers develop a highly efficient method to generate immune cells for cancer therapies

A Ludwig Cancer Research study has devised a highly efficient method to generate large numbers of immune cells specifically engineered to recognize neoantigens - small fragments of randomly mutated proteins that are typically unique to a patient's cancer - and destroy the tumors that express them.

15 Nov 2021

Blood News and Research

Model simulations show no need for DEX dose adjustments in COVID-19 patients with liver disease

Raising awareness of stroke and how to prevent it

Commonly prescribed anticoagulants may increase UTI severity

Study finds lower-quality thrombectomy outcomes for Hispanic ischemic stroke patients

New imaging software can accurately diagnose jaundice in the blink of an eye

Urinary SARS-CoV-2 RNA is a prognosticator of COVID-19

Tighter blood pressure management may lead to better spinal cord injury recovery

Scientists identify new gene that contributes to type 1 diabetes progression

Tricuspid-valve repair during mitral-valve surgery may benefit some patients

COVID-19 booster shot extremely beneficial for most cancer patients

New research finds disturbing lack of crucial blood cancer medication

Study: Covid-19 vaccine-elicited immune cells persist six months after vaccination

Drug improved cardiac structure and function in patients with early-stage hypertrophic cardiomyopathy

Elderly residents of long-term care facilities benefit from booster vaccines against SARS-CoV-2

SARS-CoV-2 replicates in human placenta with release of infectious viral particles

Lesser sodium and higher potassium intake associated with lower cardiovascular disease risk

Myocarditis among Moderna COVID-19 vaccine recipients

Rapid finger stick test to detect antibodies against SARS-CoV-2 variants

Study analyzes association between obesity and endothelial dysfunction in COVID-19 patients

Researchers develop a highly efficient method to generate immune cells for cancer therapies

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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