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Brake for skin inflammation discovered

The absence of a protein called Ctip2 in the skin allows increased levels of T-helper 2 cytokines and may have a role in conditions such as atopic dermatitis, research in mice suggests.

4 Jan 2013

Manipulating T cells with iPSC techniques could help develop effective immune therapies

The human body contains immune cells programmed to fight cancer and viral infections, but they often have short lifespans and are not numerous enough to overcome attacks by particularly aggressive malignancies or invasions.

4 Jan 2013

Researchers create killer T lymphocytes from iPS cells

Researchers from the RIKEN Research Centre for Allergy and Immunology in Japan report today that they have succeeded for the first time in creating cancer-specific, immune system cells called killer T lymphocytes, from induced pluripotent stem cells (iPS cells).

4 Jan 2013

PSCA gene’s rs2294008 variant on T nucleotide may increase risk of bladder cancer

Patients who have inherited a specific common genetic variant develop bladder cancer tumors that strongly express a protein known as prostate stem cell antigen (PSCA), which is also expressed in many pancreatic and prostate tumors, according to research at the National Institutes of Health.

4 Jan 2013

Algorithms designed to find patients with recurrent cancer within databases do not work

In order to study the effectiveness or cost effectiveness of treatments for recurrent cancer, you first have to discover the patients in medical databases who have recurrent cancer. Generally studies do this with billing or treatment codes - certain codes should identify who does and does not have recurrent cancer. A recent study published in the journal Medical Care shows that the commonly used data determinants of recurrent cancer may be misidentifying patients and potentially leading researchers astray.

4 Jan 2013

Partin Tables to predict prostate cancer spread now updated

Prostate cancer experts at Johns Hopkins have developed an updated version of the Partin Tables, a tool to help men diagnosed with prostate cancer and their doctors to better assess their chance of a surgical cure. The updated tool, based on a study of more than 5,600 men treated at The Johns Hopkins Hospital from 2006 to 2011, is published in the Jan. 3 issue of the British Journal of Urology International.

3 Jan 2013

Halt Medical receives $15M financing for commercialization of Acessa uterine fibroid treatment system

Halt Medical, Inc. announced today that it has received $15 million of financing to support commercialization of the Acessa System, a newly FDA cleared medical device to treat uterine fibroids.

2 Jan 2013

Study reveals modest association between presence of tumor boards and types of cancer care

There is little association of multidisciplinary tumor boards with measures of use, quality, or survival, and measuring only the presence of tumor boards may not be adequate in determining their effects on cancer care, according to a study published December 28 in the Journal of the National Cancer Institute.

29 Dec 2012

Heart transplant patient becomes unexpected ambassador for organ donation

Kevin Riepl arrived at Cedars-Sinai in October 2010, suffering from sudden heart failure that left him fighting for his life. Surgeons swiftly installed a heart pump and later transplanted a new heart, saving his life and turning him into an unexpected ambassador for organ donation.

29 Dec 2012

Structure, training support reliable telestroke service

Clinically relevant misinterpretation of computed tomography images via telemedicine is rare in a system that uses a structured assessment of images, say German researchers.

28 Dec 2012

New light on how epigenetic signals may function together to determine fate of stem cell

Long-standing research efforts have been focused on understanding how stem cells, cells capable of transforming into any type of cell in the body, are capable of being programmed down a defined path to contribute to the development of a specific organ like a heart, lung, or kidney. Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on how epigenetic signals may function together to determine the ultimate fate of a stem cell.

28 Dec 2012

Immune-promoting drugs may control recurrent disease

Nearly half of the 700,000 cancer patients who undergo surgical removal of a primary tumor each year suffer a recurrence of their disease at some point, and many of those patients will eventually die from their disease.

28 Dec 2012

TNF inhibitor efficacy may depend on brain activity

How well a patient responds to tumor necrosis factor inhibitor therapy may depend on brain activity reflecting the individual’s perception of their rheumatoid arthritis, scientists believe.

24 Dec 2012

Computed tomography-induced cancer risk may be overstated

Clinicians should be careful not to overemphasize the risk for radiation-induced cancer when counseling patients on undergoing surveillance computed tomography imaging, caution US scientists.

24 Dec 2012

Optic nerve assessment predicts retinoblastoma outcomes

Magnetic resonance imaging scans taken pre- and post-neoadjuvant chemotherapy for International Retinoblastoma Staging System stage III retinoblastoma can indicate a patient's likely event-free and overall survival, indicate study results.

22 Dec 2012

OncoMed commences dosing in OMP-52M51 Phase 1 clinical trial for hematologic cancers

OncoMed Pharmaceuticals, Inc., a clinical-stage company developing novel therapeutics that target cancer stem cells (CSCs), or tumor-initiating cells, today announced that patient dosing has begun in a Phase 1 clinical trial of OMP-52M51 in patients with hematologic cancers.

21 Dec 2012

Study shows how to prod stem cells to become 2 different types of blood vessel tissues

Growing new blood vessels in the lab is a tough challenge, but a Johns Hopkins engineering team has solved a major stumbling block: how to prod stem cells to become two different types of tissue that are needed to build tiny networks of veins and arteries.

21 Dec 2012

Androgen deprivation therapies may have adverse effects in men with precancers

The use of androgen deprivation therapies to prevent precancerous prostate abnormalities developing into aggressive prostate cancer may have adverse effects in men with precancers with specific genetic alterations, according to data from a preclinical study recently published in Cancer Discovery, a journal of the American Association for Cancer Research.

21 Dec 2012

Researchers develop game-changing diagnostic and prognostic genetic tests for prostate cancer

Researchers at the Kimmel Cancer Center at Jefferson (KCC) have developed potentially game-changing diagnostic and prognostic genetic tests shown to better predict prostate cancer survival outcomes and distinguish clinically-relevant cancers.

21 Dec 2012

Combination of diet and exercise may prevent breast cancer in obese, postmenopausal women

Obese, postmenopausal women are at greater risk for developing breast cancer and their cancers tend to be more aggressive than those in lean counterparts.

20 Dec 2012

Tumor News and Research

Brake for skin inflammation discovered

Manipulating T cells with iPSC techniques could help develop effective immune therapies

Researchers create killer T lymphocytes from iPS cells

PSCA gene’s rs2294008 variant on T nucleotide may increase risk of bladder cancer

Algorithms designed to find patients with recurrent cancer within databases do not work

Partin Tables to predict prostate cancer spread now updated

Halt Medical receives $15M financing for commercialization of Acessa uterine fibroid treatment system

Study reveals modest association between presence of tumor boards and types of cancer care

Heart transplant patient becomes unexpected ambassador for organ donation

Structure, training support reliable telestroke service

New light on how epigenetic signals may function together to determine fate of stem cell

Immune-promoting drugs may control recurrent disease

TNF inhibitor efficacy may depend on brain activity

Computed tomography-induced cancer risk may be overstated

Optic nerve assessment predicts retinoblastoma outcomes

OncoMed commences dosing in OMP-52M51 Phase 1 clinical trial for hematologic cancers

Study shows how to prod stem cells to become 2 different types of blood vessel tissues

Androgen deprivation therapies may have adverse effects in men with precancers

Researchers develop game-changing diagnostic and prognostic genetic tests for prostate cancer

Combination of diet and exercise may prevent breast cancer in obese, postmenopausal women

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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