Microscopy News and Research

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SARS-CoV-2 activates microglia in the brain

Researchers demonstrate that SARS-CoV-2 can infect the human microglia.

10 Jan 2022

Unique combination of nanomaterials in DNA biosensor enables easier SARS-CoV-2 detection

A recent paper that was published in the Talanta journal dedicated to original reports in pure and applied analytical chemistry presents for the first time the combination of two different nanomaterials – gold nanomaterials (AuNMs) and CDs for the development of an improved electrochemiluminescence (ECL) DNA biosensor.

10 Jan 2022

Multiscale model reveals the importance of lipids to the signaling dynamics of RAS proteins

Lawrence Livermore National Laboratory researchers and a multi-institutional team of scientists have developed a highly detailed, machine learning-backed multiscale model revealing the importance of lipids to the signaling dynamics of RAS, a family of proteins whose mutations are linked to numerous cancers.

10 Jan 2022

Researchers explore novel strategy to improve the reprogramming efficiency of human fibroblasts

Not too long ago the idea of taking, for instance a skin cell and transforming it into a muscle cell was unthinkable. About 10 years ago, however, revolutionary research showed that it is indeed possible to reprogram differentiated adult cells into other types fully capable of conducting new functions.

6 Jan 2022

Study uncovers a harmful neutrophil behavior linked to cardiovascular disease

Scientists led by Dr. Andrés Hidalgo at the Centro Nacional de Investigadores Cardiovasculares have discovered that circulating neutrophils - a type of immune cell - acquire different behavior patterns during inflammatory processes.

5 Jan 2022

Scientists provide a structural framework for Omicron immune evasion and ACE2 receptor recognition

An interesting preprint research paper describes structural changes resulting from the multiple mutations found in the recent Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is the causative agent behind the coronavirus disease 2019 (COVID-19) pandemic. In addition, the research describes the consequent effects of these changes on Omicron’s infectivity and immune evasion capabilities.

5 Jan 2022

Research provides new insights on the architecture of yeast nuclear pore complex

Nuclear pore complexes (NPCs) are massive multi-protein complexes that act as passageways for the transport of molecules into and out of the nucleus.

3 Jan 2022

Humanized antibody shows strong neutralization ability against SARS-CoV-2 Delta variant

Researchers combine SARS-CoV-2 spike vaccination with single-cell B-cell receptor sequencing technology to discover neutralizing antibody candidates.

3 Jan 2022

Study shows structural and functional aspects of antibody neutralization of SARS-CoV-2 Omicron variant

Researchers investigated the potency of trimeric human nephrocystin SH3, TriSb92, a domain-derived antibody, against a conserved region in the receptor-binding domain (RBD) of the spike protein in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern.

31 Dec 2021

SARS-CoV-2 infection and immunity in pregnancy and fetal development

A review conducted by a team of researchers from the Icahn School of Medicine at Mount Sinai, the University of Colorado, and Active Motif, Incorporated compiles information on SARS-CoV-2 virology, in utero transmission from infected pregnant mothers to fetuses, new findings on possible methods of SARS-CoV-2 cellular trafficking through exosomes, and the transcriptomic effects of SARS-CoV-2 infection, in order to inform future studies aimed at a better understanding of COVID-19 and the development of therapeutic solutions against SARS-CoV-2.

30 Dec 2021

Intestinal organoids used to explain why bats infected with viruses do not succumb to diseases

Experiments attempting to explain why bats can be infected with many viruses at a time without succumbing to diseases such as COVID-19 - knowledge that could help us to reduce the threat to humans of infectious disease - have struggled until now with the fact that live wild bats make poor research subjects.

30 Dec 2021

New techniques enable visualization of DNA repair machinery in detail

Each one of the trillions of cells that make up the human body suffers more than 10,000 DNA lesions every day. These injuries would be catastrophic if cells were unable to repair them, but a very delicate machinery that detects and repair genetic damage is at work to prevent DNA mutations and diseases such as cancer.

29 Dec 2021

Researchers unravel how our organs know when to stop growing

The smallest fish in the world, the Paedocypris, measures only 7 millimeters. This is nothing compared to the 9 meters of the whale shark.

23 Dec 2021

Cryo-EM of Omicron variant reveals antibody evasion by spike-ACE2 complex

Researchers compare the obtained binding affinities to wild-type and Delta spike proteins to determine the impact of Omicron mutations.

23 Dec 2021

Researchers identify a key influenza epitope that can targeted for developing universal vaccines

A team led by scientists at Weill Cornell Medicine, Scripps Research and the University of Chicago has identified an important site of vulnerability on influenza viruses—a site that future influenza vaccines and antibody therapies should be able to target to prevent or treat infections by a broad set of influenza strains.

23 Dec 2021

Microscopy News and Research

SARS-CoV-2 activates microglia in the brain

Unique combination of nanomaterials in DNA biosensor enables easier SARS-CoV-2 detection

Multiscale model reveals the importance of lipids to the signaling dynamics of RAS proteins

Researchers explore novel strategy to improve the reprogramming efficiency of human fibroblasts

Study uncovers a harmful neutrophil behavior linked to cardiovascular disease

Scientists provide a structural framework for Omicron immune evasion and ACE2 receptor recognition

Research provides new insights on the architecture of yeast nuclear pore complex

Humanized antibody shows strong neutralization ability against SARS-CoV-2 Delta variant

Study shows structural and functional aspects of antibody neutralization of SARS-CoV-2 Omicron variant

SARS-CoV-2 infection and immunity in pregnancy and fetal development

Intestinal organoids used to explain why bats infected with viruses do not succumb to diseases

New techniques enable visualization of DNA repair machinery in detail

Researchers unravel how our organs know when to stop growing

Cryo-EM of Omicron variant reveals antibody evasion by spike-ACE2 complex

Researchers identify a key influenza epitope that can targeted for developing universal vaccines

rVSV-based bivalent vaccine against SARS-CoV-2 delta variant and influenza

Study confirms coronavirus RNA synthesis occurs inside membrane-bound compartments

Defensosomes can act as decoys to protect against SARS-CoV-2

Researchers discover new function of protein tBID

Broad neutralization of SARS-CoV-2 spike protein by an unconventional antibody fragment

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