Signaling Pathway News and Research

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PGI2 analogs, PDE5 inhibitors stimulate enhanced release of vasodilator ATP from human RBCs

Researchers at Saint Louis University School of Medicine have discovered a novel interaction between prostacyclin analogs and phosphodiesterase 5 inhibitors, two groups of drugs used in the treatment of pulmonary arterial hypertension.

21 Sep 2013

Study sheds new light on the dark matter of genome

Using technology he helped develop, Vanderbilt University scientist Bryan Venters, Ph.D., has shed new light on the "dark matter" of the genome and has begun to explore a possible new approach to treating cancer.

19 Sep 2013

Wnt proteins essential to formation of long-term memories

Scientists from the Florida campus of The Scripps Research Institute have found a group of proteins essential to the formation of long-term memories.

13 Sep 2013

Weill Cornell Medical College gets $100M gift to launch Driving Discoveries, Changing Lives campaign

Weill Cornell Medical College announced today that it has received a $100 million gift from longtime benefactors Joan and Sanford I. Weill and the Weill Family Foundation to launch the Medical College's $300 million Driving Discoveries, Changing Lives campaign dedicated to using the most advanced scientific approaches to rapidly translate research breakthroughs into innovative treatments and therapies for patients.

10 Sep 2013

Antenatal taurine reduces cerebral cell apoptosis in fetal rats with intrauterine growth restriction

Increased brain cell apoptosis in intrauterine growth-restricted fetal rats is a key reason for unfavorable long-term prognosis of the nervous system. The harmful effects of intrauterine growth restriction on fetal brain development originate in the womb.

6 Sep 2013

Inner-ear dysfunction can increase hyperactivity, say researchers

Behavioral abnormalities are traditionally thought to originate in the brain. But a new study by researchers at Albert Einstein College of Medicine of Yeshiva University has found that inner-ear dysfunction can directly cause neurological changes that increase hyperactivity.

6 Sep 2013

Scientists unravel how DNA damage may trigger lupus erythematosus

Summer, sun and the sea - a dream vacation for most - can turn sour for those affected by lupus erythematosus. For them, absorption of the UV-light component in sunlight may cause florid inflammation and redness of the skin. Scientists of the University Hospital Bonn, Germany have now discovered which signaling pathway of the innate immune system promotes autoimmune symptoms following sun-induced DNA damage.

30 Aug 2013

Study points to potential new therapeutic target for preventing birth defects in women with diabetes

A research team at the University of Maryland School of Medicine has identified a cell signaling pathway which plays a significant role in causing developmental defects of the fetal spinal cord and brain in babies of women with diabetes.

29 Aug 2013

UAB study points to protein pathway that could lead to new treatments for diabetes

The same protein tells beta cells in the pancreas to stop making insulin and then to self-destruct as diabetes worsens, according to a University of Alabama at Birmingham study published online today in the journal Nature Medicine.

27 Aug 2013

Houston scientists receive $1.3M grant to study how immune system drives multiple sclerosis

A $1.3 million grant from the National Institute of Neurological Disorders and Stroke could help Houston Methodist scientists better understand how the body's own immune system drives multiple sclerosis.

26 Aug 2013

Research findings lay foundation for regenerating damaged heart muscle

In the aftermath of a heart attack, cells within the region most affected shut down. They stop beating. And they become entombed in scar tissue. But now, scientists at the Gladstone Institutes have demonstrated that this damage need not be permanent-by finding a way to transform the class of cells that form human scar tissue into those that closely resemble beating heart cells.

23 Aug 2013

MC1R mutation responsible for red hair phenotype also promotes cancer-causing pathway

A person's skin pigment, which determines hair color and skin tone, is influenced by the melanocortin-1 (MC1R) gene receptor. For the population's one to two percent of redheads, a mutation in MC1R accounts for their red hair color and typical light skin.

23 Aug 2013

Medical investigators discover new aspect of gene-splicing process that produces mRNA

A rare, small RNA turns a gene-splicing machine into a switch that controls the expression of hundreds of human genes. Howard Hughes Medical Institute Investigator and professor of Biochemistry Gideon Dreyfuss, PhD, and his team from the Perelman School of Medicine at the University of Pennsylvania, discovered an entirely new aspect of the gene-splicing process that produces messenger RNA (mRNA).

22 Aug 2013

TSRI scientists decode important molecular signal that guides development of neocortex

Scientists at The Scripps Research Institute have decoded an important molecular signal that guides the development of a key region of the brain known as the neocortex. The largest and most recently evolved region of the brain, the neocortex is particularly well developed in humans and is responsible for sensory processing, long-term memory, reasoning, complex muscle actions, consciousness and other functions.

8 Aug 2013

Scientists identify important molecular signal that guides development of brain

Scientists at The Scripps Research Institute (TSRI) have decoded an important molecular signal that guides the development of a key region of the brain known as the neocortex.

8 Aug 2013

Study shows how bioactive component in soy foods plays a role against colon cancer

University of Illinois scientists have evidence that lifelong exposure to genistein, a bioactive component in soy foods, protects against colon cancer by repressing a signal that leads to accelerated growth of cells, polyps, and eventually malignant tumors.

6 Aug 2013

New findings could enable development of effective drugs for addiction with fewer side effects

Scientists from the Florida campus of The Scripps Research Institute have described findings that could enable the development of more effective drugs for addiction with fewer side effects.

3 Aug 2013

Research opens potential new avenue for cancer treatment

Scientists at The University of Texas MD Anderson who identified a protein's dual role in cancer promotion have discovered a way to shut it down, opening a potential new avenue for cancer treatment.

2 Aug 2013

Cyp11a1 enzyme is a potential target for treatment of deadly food allergy, say researchers

Researchers at National Jewish Health have identified an enzyme that is essential to the allergic reaction to peanuts. Blocking the enzyme's activity in sensitized mice prevented diarrhea and inflammation, and reduced levels of several proteins associated with allergies.