Genetic News and Research

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Salk Institute researchers uncover molecular structure of RNA-based CRISPR system

Over the past several years, CRISPR-Cas9 has moved beyond the lab bench and into the public zeitgeist. This gene-editing tool CRISPR-Cas9 holds promise for correcting defects inside individual cells and potentially healing or preventing many human ailments.

20 Sep 2018

Novel mathematical approach uncovers existence of unsuspected biological cycles

A novel mathematical approach has uncovered that some animal cells have robust 12-hour cycles of genetic activity, in addition to circadian or 24-hour cycles.

20 Sep 2018

New type of fatty acid can slow down overreactive immune system

Sometimes, the body's otherwise intelligent immune system mistakenly attacks the body's healthy tissue by responding to infections that do not exist.

20 Sep 2018

Podcast: KHN’s ‘What the Health?’ Health on the hill

As the start of the fiscal year draws near — along with pivotal midterm elections — Congress is picking up its pace on legislation. This week alone the Senate passed a comprehensive bill aimed at curbing the opioid epidemic and a nearly final bill to fund the Department of Health and Human Services.

20 Sep 2018

LineaRx signs agreement with Takis/Evvivax to develop linear-DNA based anti-cancer vaccines

Applied DNA Sciences Inc. announced today that LineaRx, Inc., its wholly-owned subsidiary focused on next-generation biotherapeutics, has signed a Joint Development Agreement with Takis S.R.L. and Evvivax S.R.L., biotechnology companies focused on the discovery and development of DNA based anti-cancer vaccines for the human and animal markets, respectively.

20 Sep 2018

Genetic polymorphisms linked with muscle injury and stiffness

To test whether sex-related genetic polymorphisms are associated with muscle injury and stiffness, Noriyuki Fuku from Juntendo University and colleagues report in the journal Medicine & Science in Sports & Exercise that ESR1 rs2234693 polymorphism is associated with both muscle injury and muscle stiffness.

20 Sep 2018

Study could allow doctors to screen patients at risk from Aspergillus

Scientists at The University of Manchester have discovered a genetic mutation in humans linked to a 17-fold increase in the amount of dangerous fungal spores in the lungs.

20 Sep 2018

Geroscience takes center stage in Journal of the American Medical Association

Geroscience--the burgeoning research field that focuses on the genetic, molecular, and cellular mechanisms that make aging a major risk factor for most chronic diseases as we age--takes center stage in the Journal of the American Medical Association, the world's most widely circulated medical journal.

20 Sep 2018

Detection of BFD virus in parrots in 8 new countries raises concerns for threatened species

Beak and feather disease virus in wild parrot populations has been detected in eight new countries, raising concerns for threatened species.

20 Sep 2018

New study focuses on two-way gene switches controlling gene activity

Led by ICREA research professors at the Centre for Genomic Regulation, Luciano Di Croce and Marc A. Marti-Renom, the study focused on a set of genes with what's known as bivalent promoters - two-way genetic 'control switches' that are poised either to turn on in early development and rapidly drive high levels of gene activity, or to switch off and shut down the gene completely.

20 Sep 2018

First U.S. patient treated with innovative gene therapy at Bascom Palmer Eye Institute

A Puerto Rican patient with X-linked retinitis pigmentosa (XLRP) is hoping to save his vision after an innovative gene therapy procedure at Bascom Palmer Eye Institute at the University of Miami Miller School of Medicine.

19 Sep 2018

New chemo-optogenetic method enables multi-directional activity control of cellular processes

Cells need for reactions on environmental changes and a balanced system of signaling cascades within the cell. Proteins outside of the cell, on the cellular surface, inside the cellular membrane, and within the cell orchestrate many fine-tuned signaling pathways, which result in adequate reactions on the environmental conditions or changes in the organism itself.

19 Sep 2018

Researchers use larval zebrafish model to reveal role of locus coeruleus in anesthesia

The application of general anesthesia in clinical therapy has been an indispensable part of modern medicine for more than a century. However, due to the complexity of the brain and the extensive actions of general anesthetic drugs, neural mechanisms underlying general anesthesia have remained a mystery.

19 Sep 2018

Study reveals new therapeutic target for pediatric tumor-associated intractable epilepsy

Pediatric brain tumors are characterized by frequent complications due to intractable epilepsy compared to adult brain tumors. However, the genetic cause of refractory epilepsy in pediatric brain tumors has not been elucidated yet, and it is difficult to treat patients because the tumors do not respond to existing antiepileptic drugs and debilitate children's development.

19 Sep 2018

Ipsen receives approval from Health Canada for CABOMETYX tablets for treating renal cell carcinoma

Exelixis, Inc. today announced that its partner Ipsen Biopharmaceuticals Canada Inc. received approval from Health Canada of CABOMETYX® tablets for the treatment of adults with advanced renal cell carcinoma who have received prior vascular endothelial growth factor targeted therapy.

19 Sep 2018

Cancer Research UK invests £14 million to transform London into cancer biotherapeutics hub

The city of London will be transformed into a world leading hub for cancer biotherapeutics research and treatment, with a new £14 million investment from Cancer Research UK, announced today (Monday).

19 Sep 2018

Researchers describe cell mechanism that optimizes proteins production in stressful situations

The different genes within the genome must be expressed in precise levels and in the exact moment if the complex balance regulating cell activity is to be maintained.

19 Sep 2018

Women with high levels of anti-Müllerian hormone more likely to develop breast cancer

Having high levels of anti-Müllerian hormone – a hormone that indicates the size of a woman’s ovarian reserve – before the menopause is associated with an increased risk of breast cancer, new research suggests.

19 Sep 2018

Young children's oral microbiota could serve as early indicator for obesity

Weight gain trajectories in early childhood are related to the composition of oral bacteria of two-year-old children, suggesting that this understudied aspect of a child's microbiota -- the collection of microorganisms, including beneficial bacteria, residing in the mouth -- could serve as an early indicator for childhood obesity.

19 Sep 2018

TGen and PNOC take part in launch of NIH-supported Kids First Data Resource Portal

As part of a national initiative to solve children's diseases, the Translational Genomics Research Institute and the Pacific Pediatric Neuro-Oncology Consortium are participating in the launch of the Kids First Data Resource Portal, which is supported by the National Institutes of Health .

19 Sep 2018

Genetic News and Research

Salk Institute researchers uncover molecular structure of RNA-based CRISPR system

Novel mathematical approach uncovers existence of unsuspected biological cycles

New type of fatty acid can slow down overreactive immune system

Podcast: KHN’s ‘What the Health?’ Health on the hill

LineaRx signs agreement with Takis/Evvivax to develop linear-DNA based anti-cancer vaccines

Genetic polymorphisms linked with muscle injury and stiffness

Study could allow doctors to screen patients at risk from Aspergillus

Geroscience takes center stage in Journal of the American Medical Association

Detection of BFD virus in parrots in 8 new countries raises concerns for threatened species

New study focuses on two-way gene switches controlling gene activity

First U.S. patient treated with innovative gene therapy at Bascom Palmer Eye Institute

New chemo-optogenetic method enables multi-directional activity control of cellular processes

Researchers use larval zebrafish model to reveal role of locus coeruleus in anesthesia

Study reveals new therapeutic target for pediatric tumor-associated intractable epilepsy

Ipsen receives approval from Health Canada for CABOMETYX tablets for treating renal cell carcinoma

Cancer Research UK invests £14 million to transform London into cancer biotherapeutics hub

Researchers describe cell mechanism that optimizes proteins production in stressful situations

Women with high levels of anti-Müllerian hormone more likely to develop breast cancer

Young children's oral microbiota could serve as early indicator for obesity

TGen and PNOC take part in launch of NIH-supported Kids First Data Resource Portal

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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