Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Drug used to treat myelofibrosis can awaken ‘dormant’ lymphomas in the bone marrow

Most patients with myelofibrosis, a rare chronic disorder of the haematopoietic cells of the bone marrow, benefit from drugs from the JAK2 inhibitor class: symptoms are relieved, survival extended and general quality-of-life enhanced.

18 Jun 2018

Study unravels 'blood stem cell niche' puzzle

In humans and other mammals, the stem cells that give rise to all blood cells are located in the bone. But in fish, blood stem cells are found in the kidney. Since the late 1970s, when biologists first realized that blood develops in a specific location in the body — the ‘blood stem cell niche’ — they have wondered why different creatures have evolved to carry out this function in different locations.

18 Jun 2018

Synthetic gene reveals potential therapeutic target for rare, inherited disease

DNA Repair is essential for a healthy organism. In every day of our lives, tens of thousands of damages occur in the genetic material of our cells. Hence, it is not surprising that a broad variety of repair mechanisms developed in the course of evolution that enables cells to quickly react and patch up the affected DNA strands.

11 Jun 2018

Study demonstrates that HIV infection in the brain can be established, maintained by T cells

A new study by University of North Carolina School of Medicine researchers has found that T cells, a type of white blood cell and an essential part of the immune system, are sufficient by themselves to establish and maintain an HIV infection in the brain.

6 Jun 2018

FDA approves first Neulasta biosimilar to help decrease infection risk during cancer treatment

The U.S. Food and Drug Administration today approved Fulphila (pegfilgrastim-jmdb) as the first biosimilar to Neulasta (pegfilgrastim) to decrease the chance of infection as suggested by febrile neutropenia (fever, often with other signs of infection, associated with an abnormally low number of infection-fighting white blood cells), in patients with non-myeloid (non-bone marrow) cancer who are receiving myelosuppressive chemotherapy that has a clinically significant incidence of febrile neutropenia.

4 Jun 2018

FDA-approved drug for lymphoma and leukemia may help treat common type of brain tumor

New Cleveland Clinic research shows for the first time that ibrutinib, an FDA-approved drug for lymphoma and leukemia, may also help treat the most common – and deadliest – type of brain tumor.

30 May 2018

Study shows blood stem cells compensate for immune cell deficiencies

Researchers have shown that if certain blood stem cells that produce immune cells are deficient, other blood stem cells compensate by overproducing the immune cells that are lacking.

30 May 2018

FDA approves new drug to treat thrombocytopenia in adults with chronic liver disease

The U.S. Food and Drug Administration today approved Doptelet (avatrombopag) tablets to treat low blood platelet count (thrombocytopenia) in adults with chronic liver disease who are scheduled to undergo a medical or dental procedure. This is the first drug approved by the FDA for this use.

22 May 2018

Scientists identify new potential target to combat acute myeloid leukemia

AML is not a single disease. It is a group of leukemias that develop in the bone marrow from progenitors of specialized blood cells, the so-called myeloid cells. Rapidly growing and dividing, these aberrant cells crowd the bone marrow and bloodstream, which can be fatal within weeks or months if the disease is left untreated.

18 May 2018

Study: Single surface protein can amplify multiple key pathways in acute myeloid leukemia

Researchers from the Albert Einstein College of Medicine in New York have discovered that a signaling protein elevated in patients with acute myeloid leukemia plays a much wider role in the disease than previously thought.

18 May 2018

Rocket Pharma partners with Stanford University to advance FA and PKD gene therapy research

Rocket Pharmaceuticals, Inc., a leading U.S.-based multi-platform gene therapy company, and the Stanford University School of Medicine today announced a strategic collaboration to support the advancement of Fanconi Anemia and Pyruvate Kinase Deficiency gene therapy research.

17 May 2018

FDA allows KU Medical Center to begin clinical trial of novel cellular therapy for HR/SR aGvHD

The University of Kansas Medical Center announced that the U.S. Food and Drug Administration has cleared it to begin a first-in-human clinical trial of MSCTC-0010 in patients with de novo high-risk acute or steroid-refractory acute graft-versus-host disease (HR/SR aGvHD).

16 May 2018

First epoetin alfa biosimilar receives FDA approval to treat certain types of anemia

The U.S. Food and Drug Administration today approved Retacrit (epoetin alfa-epbx) as a biosimilar to Epogen/Procrit (epoetin alfa) for the treatment of anemia caused by chronic kidney disease, chemotherapy, or use of zidovudine in patients with HIV infection.

16 May 2018

Research suggests novel therapies to lower cardiovascular disease risk in rheumatoid arthritis patients

Preclinical and early clinical research conducted by teams at the University of Alabama at Birmingham and in Australia suggests that patients with rheumatoid arthritis could lower their risk of cardiovascular disease through cholesterol-lowering therapies, according to research published in the European Heart Journal.

15 May 2018

New technique aims to expand understanding of mechanical forces existing between cells

A new technique that uses tiny elastic balls filled with fluorescent nanoparticles aims to expand the understanding of the mechanical forces that exist between cells, researchers report.

14 May 2018

UAB expert highlights need to do more trials in the epidemic center of disease

Frances Lund, Ph.D., the Charles H. McCauley Chair of Microbiology at the University of Alabama at Birmingham, spoke about chronic inflammatory disease and the striking correlation between location and disease incidence at the recent Fourth International Vatican Conference, "Unite to Cure."

11 May 2018

New study aims to mitigate risks associated with treatment of multiple myeloma

In a 10-patient cohort study led by Dr. Jean Roy that aims to understand how to mitigate the risks associated with the treatment of multiple myeloma, a malignant cancer, researchers have adopted an innovative approach based on the unique immunological properties of umbilical cord blood in an effort to improve the safety and efficiency of allografting, the preferred treatment for this disease

11 May 2018

CMS approves national reimbursement coverage for CardiAMP Chronic Myocardial Ischemia Trial

BioCardia, Inc., a leader in the development of comprehensive solutions for cardiovascular regenerative therapies, today announced that the Centers for Medicare and Medicaid Services has approved national reimbursement coverage for the CardiAMP Chronic Myocardial Ischemia Trial.

10 May 2018

New case study shows CAR T therapy as viable option for AML patients

Chimeric Antigen Receptor T-cell therapy, also known as CAR T therapy, was named the biggest research breakthrough of 2017 by the American Society of Clinical Oncology. The personal gene therapy utilizes a patient's own immune cells to fight cancer.

9 May 2018

Bone marrow is an important reservoir for replication and transmission of malaria parasites, shows study

A Plasmodium vivax infection is like an iceberg: It's dangerous, in part, because much of it hides out of view.

8 May 2018