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New assay may help improve both sarcoma diagnosis and treatment

Sarcomas are rare tumors that are often misdiagnosed. Specific recurrent chromosomal rearrangements, known as translocations, can serve as essential diagnostic markers and are found in about 20 percent of sarcomas.

20 Aug 2018

Scientists identify pathways that reveal insights into mechanism of lung cancer etiology

Lung cancer is the leading cause of preventable cancer death. A disease of complex origin, lung cancer is usually considered to result from effects of smoking and from multiple genetic variants.

17 Aug 2018

Scientists introduce microfluidics-based chip for manipulation and analysis of single cells

A few little cells that are different from the rest can have a big effect. For example, individual cancer cells may be resistant to a specific chemotherapy--causing a relapse in a patient who would otherwise be cured. In the journal Angewandte Chemie, scientists have now introduced a microfluidics-based chip for the manipulation and subsequent nucleic-acid analysis of individual cells.

17 Aug 2018

Researchers discuss techniques to help combat growing epidemic of obesity

More than 60 percent of American adults weigh more than is healthy, which results in increased health issues for the patient and high health care costs.

17 Aug 2018

New CRISPR technology may help eliminate mutated gene sequence

In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell's internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building.

17 Aug 2018

NUS study discovers a bidirectional regulator and shines light on A-to-I RNA editing in cancer cells

An in-depth study on the regulation of adenosine-to-inosine (A-to-I) RNA editing by researchers from the Cancer Science Institute of Singapore at the National University of Singapore found that a protein, known as DHX9, acts as a bidirectional regulator of the molecular process which is linked to various types of cancer such as esophageal cancer.

17 Aug 2018

Island Fertility joins Stony Brook Community Medical to provide comprehensive fertility care

Island Fertility has joined Stony Brook Community Medical, expanding to 23 the number of Stony Brook Medicine's network of community practices and physicians. The group offers comprehensive and integrated fertility care at Stony Brook Advanced Specialty Care facility in Commack, with a plan to add additional Long Island office locations.

17 Aug 2018

Female mosquitoes quickly evolve selective mating behavior when faced with threats

Certain female mosquitoes quickly evolve more selective mating behavior when faced with existential threats from other invasive mosquito species, with concurrent changes to certain genetic regions, according to new research from North Carolina State University.

17 Aug 2018

Seeking solutions to treat scleroderma

It begins with cold hands. Not just put-on-some-gloves cold. Instead, the fingers overreact to cold by turning white or blue and may become numb or tingly.

17 Aug 2018

Study: Sperm morphology differs depending on qualities of male bird

In a study published in Behavioral Ecology researchers from Uppsala University show that the same type of sperm is not always the best for all male birds.

17 Aug 2018

Research uncovers miscarriage cause, identifies potential targets for treatment

Tragic miscarriages for a couple have led to a discovery with potentially broad implications for future disease treatments, according to a team of researchers at the University of North Carolina School of Medicine. They identified a previously undiscovered gene mutation underlying hydrops fetalis – a fatal condition to fetuses due to fluid buildup in the space between organs.

16 Aug 2018

Study finds role of autoimmunity in development of COPD

Autoimmunity plays a role in the development of chronic obstructive pulmonary disease (COPD), according to a study led by Georgia State University and Vanderbilt University Medical Center that analyzed human genome information stored in Vanderbilt's DNA biobank.

16 Aug 2018

NIH begins first-in-human trial of experimental live, attenuated Zika virus vaccine

Vaccinations have begun in a first-in-human trial of an experimental live, attenuated Zika virus vaccine developed by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

16 Aug 2018

Experts advise against universal genomic screening of newborns

In a new report, experts at The Hastings Center advise against genomic screening of newborns, despite it's potential for providing life long personalized care.

16 Aug 2018

Scientists uncover key control mechanism of DNA replication

Researchers from Osaka University in Japan have uncovered a key control mechanism of DNA replication with potential implications for better understanding how cells maintain genetic information to prevent diseases or cancer.

16 Aug 2018

FDA expands approval of Vertex' cystic fibrosis medicine to treat children aged 12 to <24 months

Vertex Pharmaceuticals Incorporated today announced the U.S. Food and Drug Administration approved KALYDECO® (ivacaftor) to include use in children with cystic fibrosis ages 12 to <24 months who have at least one mutation in their cystic fibrosis transmembrane conductance regulator gene that is responsive to KALYDECO based on clinical and/or in vitro assay data.

16 Aug 2018

Report discusses whether all newborns should undergo genetic sequencing

As the cost of genome sequencing decreases, researchers and clinicians are debating whether all newborns should be sequenced at birth, facilitating a lifetime of personalized medical care.

16 Aug 2018

Penn researchers develop first mouse model of idiopathic pulmonary fibrosis

The biggest hurdle to finding effective therapies for idiopathic pulmonary fibrosis (IPF) – a life-threatening condition in which the lungs become scarred and breathing is increasingly difficult – has been the inability to fully model the disease in animals, limiting the ability to observe and understand the disease.

16 Aug 2018

Tufts researchers win grant to study integration of genomic sequencing into neonatal care

Tufts Medical Center researchers have received a five-year grant award for more than $8 million from the National Center For Advancing Translational Sciences of the National Institutes of Health to study the integration of targeted genomic sequencing into neonatal diagnosis and care.

16 Aug 2018

Study uncovers mechanism that affects multiplication of dengue virus lineage

A lineage of type 1 dengue virus found in Brazil is able to prevail over another even though it multiplies less in vector mosquitoes and infected human cells.

15 Aug 2018

Genetic News and Research

New assay may help improve both sarcoma diagnosis and treatment

Scientists identify pathways that reveal insights into mechanism of lung cancer etiology

Scientists introduce microfluidics-based chip for manipulation and analysis of single cells

Researchers discuss techniques to help combat growing epidemic of obesity

New CRISPR technology may help eliminate mutated gene sequence

NUS study discovers a bidirectional regulator and shines light on A-to-I RNA editing in cancer cells

Island Fertility joins Stony Brook Community Medical to provide comprehensive fertility care

Female mosquitoes quickly evolve selective mating behavior when faced with threats

Seeking solutions to treat scleroderma

Study: Sperm morphology differs depending on qualities of male bird

Research uncovers miscarriage cause, identifies potential targets for treatment

Study finds role of autoimmunity in development of COPD

NIH begins first-in-human trial of experimental live, attenuated Zika virus vaccine

Experts advise against universal genomic screening of newborns

Scientists uncover key control mechanism of DNA replication

FDA expands approval of Vertex' cystic fibrosis medicine to treat children aged 12 to <24 months

Report discusses whether all newborns should undergo genetic sequencing

Penn researchers develop first mouse model of idiopathic pulmonary fibrosis

Tufts researchers win grant to study integration of genomic sequencing into neonatal care

Study uncovers mechanism that affects multiplication of dengue virus lineage

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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