Signaling Pathway News and Research

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Study confirms role of MAPK mutations in pilocytic astrocytomas

Brain cancer is the primary cause of cancer mortality in children. Even in cases when the cancer is cured, young patients suffer from the stress of a treatment that can be harmful to the developing brain. In a search for new target structures that would create more gentle treatments, cancer researchers are systematically analyzing all alterations in the genetic material of these tumors.

10 Jul 2013

p53 restoration of function drug candidate: an interview with Dr. Wayne Danter, MD, FRCPC President and CEO of Critical Outcome Technologies

COTI-2 is a computer-designed small molecule that was discovered by our artificial intelligence drug discovery platform called CHEMSAS.

8 Jul 2013

Study identifies genomic regions associated with cholera susceptibility

An international research team has used a novel approach to identify genetic factors that appear to influence susceptibility to cholera. The findings by investigators from Massachusetts General Hospital (MGH), the Broad Institute and the International Center for Diarrh-al Disease Research, Bangladesh (ICDDR,B) indicate the importance of pathways involved in regulating water loss in intestinal cells and of the innate immune system in the body's response to the bacteria that causes cholera, which affects from 3 to 5 million people each year and causes more than 100,000 deaths.

4 Jul 2013

Scientists identify molecular signals that spur the formation of arteries

The ability to form blood vessels is one of evolution's crowning achievements, and something that separates vertebrates (animals with a backbone) from the rest of the animal kingdom.

4 Jul 2013

Scientists discover network for molecular communication in human embryonic stem cells

Scientists at A*STAR's Genome Institute of Singapore (GIS) and the Max Planck Institute for Molecular Genetics (MPIMG) in Berlin (Germany) have discovered a molecular network in human embryonic stem cells (hESCs) that integrates cell communication signals to keep the cell in its stem cell state.

3 Jul 2013

Scientists find new links in gene networks that control movement

The idea that worms can be seen as waveforms allowed scientists at Rice University to find new links in gene networks that control movement.

2 Jul 2013

Research suggests new models for study of Barrett's esophagus

Research focused on the regulation of the adult stem cells that line the gastrointestinal tract of Drosophila suggests new models for the study of Barrett's esophagus.

28 Jun 2013

Caspase-2 protein contributes to cognitive decline associated with Alzheimer's disease

Researchers at Columbia University Medical Center have demonstrated that a protein called caspase-2 is a key regulator of a signaling pathway that leads to cognitive decline in Alzheimer's disease.

26 Jun 2013

UCSF scientists explore how Dact1 mutations contribute to psychiatric disorders

Gene mutations that cause cell signaling networks to go awry during embryonic development and lead to major birth defects may also cause subtle disruptions in the brain that contribute to psychiatric disorders such as schizophrenia, autism, and bipolar disorder, according to new research by UC San Francisco scientists.

25 Jun 2013

TSRI neuroscientists fill in significant gap in the understanding of how neurons mature

Neuroscientists at The Scripps Research Institute have filled in a significant gap in the scientific understanding of how neurons mature, pointing to a better understanding of some developmental brain disorders.

21 Jun 2013

Targeting particular signaling pathway can help prevent temporal lobe epilepsy, scientists report

Temporal lobe epilepsy, the most common form of epilepsy, is characterized by recurrent seizures throughout life and often behavioral abnormalities, with devastating impacts on patients and their families. Unfortunately, the condition is often not responsive to anticonvulsants. Now scientists report online June 20 in the Cell Press journal Neuron that targeting a particular signaling pathway in mice can prevent the development of temporal lobe epilepsy with just two weeks of treatment, offering hope that researchers will be able to develop effective drugs to mitigate recurrent seizures and the development of epilepsy.

21 Jun 2013

Researchers monitor dynamic cellular events that take place during cardiac regeneration in zebrafish

In a study published in the June 19 online edition of the journal Nature, a scientific team led by researchers from the University of California, San Diego School of Medicine visually monitored the dynamic cellular events that take place when cardiac regeneration occurs in zebrafish after cardiac ventricular injury. Their findings provide evidence that various cell lines in the heart are more plastic, or capable of transformation into new cell types, than previously thought.

20 Jun 2013

Signaling pathway correlates with EGFR status and poor survival in breast cancer patients

Researchers have discovered and mapped the signaling network between two previously unconnected proteins, exposing a link that, if broken, could cut off cancer cell growth at its starting point.

19 Jun 2013

Scientists find that psychiatric disorders may be linked to protein involved in memory formation

Researchers have discovered a pathway by which the brain controls a molecule critical to forming long-term memories and connected with bipolar disorder and schizophrenia.

17 Jun 2013

PRISM Pharma announces closing of $15 million Series C financing

PRISM Pharma Co., Ltd., a drug discovery company focused on developing small molecule technologies that modulate protein-protein interactions, today announced the close of an approximately $15 million (approximately ¥1.4 billion) Series C financing.

13 Jun 2013

Verastem's VS-6063 gets orphan drug designation from European Commission for use in mesothelioma

Verastem, Inc., focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, announced that VS-6063 has received orphan medicinal product designation from the European Commission for use in mesothelioma.

13 Jun 2013

Researchers identify biochemical pathway that links nail growth to fingertip regeneration

Mammals possess the remarkable ability to regenerate a lost fingertip, including the nail, nerves and even bone. In humans, an amputated fingertip can sprout back in as little as two months, a phenomenon that has remained poorly understood until now. In a paper published today in the journal Nature, researchers at NYU Langone Medical Center shed light on this rare regenerative power in mammals, using genetically engineered mice to document for the first time the biochemical chain of events that unfolds in the wake of a fingertip amputation.

13 Jun 2013

Signaling Pathway News and Research

Study confirms role of MAPK mutations in pilocytic astrocytomas

p53 restoration of function drug candidate: an interview with Dr. Wayne Danter, MD, FRCPC President and CEO of Critical Outcome Technologies

Study identifies genomic regions associated with cholera susceptibility

Scientists identify molecular signals that spur the formation of arteries

Scientists discover network for molecular communication in human embryonic stem cells

Scientists find new links in gene networks that control movement

Research suggests new models for study of Barrett's esophagus

Caspase-2 protein contributes to cognitive decline associated with Alzheimer's disease

UCSF scientists explore how Dact1 mutations contribute to psychiatric disorders

TSRI neuroscientists fill in significant gap in the understanding of how neurons mature

Targeting particular signaling pathway can help prevent temporal lobe epilepsy, scientists report

Researchers monitor dynamic cellular events that take place during cardiac regeneration in zebrafish

Signaling pathway correlates with EGFR status and poor survival in breast cancer patients

Scientists find that psychiatric disorders may be linked to protein involved in memory formation

PRISM Pharma announces closing of $15 million Series C financing

Verastem's VS-6063 gets orphan drug designation from European Commission for use in mesothelioma

Researchers identify biochemical pathway that links nail growth to fingertip regeneration

TSRI scientists identify key triggers of cancer-blocking mechanism in cells

Cytomegalovirus might accelerate the development of glioblastoma

Harmless genetic variations may team up to increase risk of schizophrenia, find researchers

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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