Inflammation News and Research

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Probiotic bacterial protein could offer new oral therapeutic option for inflammatory bowel disorders

A protein isolated from beneficial bacteria found in yogurt and dairy products could offer a new, oral therapeutic option for inflammatory bowel disorders, suggests a study led by Vanderbilt University Medical Center researcher Fang Yan, M.D., Ph.D.

24 May 2011

Vertex Incivek receives FDA approval for treatment of chronic hepatitis C

The U.S. Food and Drug Administration today approved Incivek treat certain adults with chronic hepatitis C infection. Incivek is used for patients who have either not received interferon-based drug therapy for their infection or who have not responded adequately to prior therapies. Incivek is approved for use with interferon therapy made up of peginterferon alfa and ribavirin.

24 May 2011

Journal of Clinical Oncology publishes Exelixis' cabozantinib phase 1 trial results in lymphoma

Exelixis, Inc. today announced the results of the phase 1 clinical trial of cabozantinib in patients with advanced solid tumors or lymphoma have been published in the current issue of the Journal of Clinical Oncology.

24 May 2011

Researchers discover new genes that influence severity of cystic fibrosis

Johns Hopkins Institute for Genetic Medicine researchers working as part of the North American Cystic Fibrosis Consortium have discovered two regions of the genome that affect the severity of cystic fibrosis, a genetic condition that causes scarring throughout the body, affecting most notably the pancreas and lungs.

23 May 2011

Tumor necrosis factor can suppress inflammation, treat rheumatoid arthritis

A new study by rheumatologists at Hospital for Special Surgery in New York has shown that a powerful pro-inflammatory protein, tumor necrosis factor, can also suppress aspects of inflammation.

23 May 2011

Feeding SimplyThick to premature infants may cause NEC, warns FDA

FDA is warning parents, caregivers and health care providers not to feed SimplyThick, a thickening agent for management of swallowing disorders, to infants born before 37 weeks.

21 May 2011

FDA approves Sutent for patients with progressive neuroendocrine cancerous tumors in pancreas

The U.S. Food and Drug Administration today approved Sutent (sunitinib) to treat patients with progressive neuroendocrine cancerous tumors located in the pancreas that cannot be removed by surgery or that have spread to other parts of the body (metastatic).

21 May 2011

Bitter cumin contains high levels of antioxidants and protects against DNA damage

Bitter cumin is used extensively in traditional medicine to treat a range of diseases from vitiligo to hyperglycemia. It is considered to be antiparasitic and antimicrobial and science has backed up claims of its use to reduce fever or as a painkiller. New research published in BioMedCentral's open access journal BMC Complementary and Alternative Medicine shows that this humble spice also contains high levels of antioxidants.

20 May 2011

Naltrexone improves clinical, inflammatory activity in Crohn's disease patients

Naltrexone reduced inflammation in Crohn's patients in a research study at Penn State College of Medicine.

20 May 2011

PolyMedix's PMX-30063 compound mitigates ulcerative mucositis in pre-clinical studies

PolyMedix, Inc., a biotechnology company focused on developing new therapeutic drugs to treat patients with acute infectious diseases and cardiovascular disorders, announced today that its lead defensin-mimetic antibiotic compound, PMX-30063, when administered topically as an oral rinse, has shown activity against oral mucositis in an animal study.

19 May 2011

New technique offers successful bone marrow, organ transplant for patients with autoimmune diseases

University of Minnesota Medical School researchers have discovered a method to quickly and exponentially grow regulatory T-cells - also known as "suppressor cells." The new process enables replication of the cells by tens of millions in several weeks, a dramatic increase over previous duplication methods. Historically, regulatory T-cells have been difficult to replicate.

19 May 2011

Study suggests link between obesity, psoriasis and heart disease risk in children

Children who are overweight or obese have a significantly higher prevalence of psoriasis, and teens with psoriasis, regardless of their body weight, have higher cholesterol levels, according to a Kaiser Permanente study published online in the Journal of Pediatrics.

19 May 2011

Silodosin helps reduce chronic prostatitis in men

New findings show that treatment with a specific alpha blocker helps reduce symptoms and improve quality of life for men with chronic prostatitis/chronic pelvic pain syndrome.

18 May 2011

Workplace smoking ban improves respiratory health and reduces emergency admissions

Workplace smoking bans are gaining ground globally, and one study has shown that they may have significant health effects. The study, conducted by researchers in Dublin, found that emergency room admissions due to respiratory illness dropped significantly in Ireland after the implementation of a workplace smoking ban, compared to admissions that took place before the ban went into effect.

18 May 2011

Coffee reduces prostate cancer risk

In the 20-year study of almost 50,000 men, researchers noted that those who drank at least six cups a day were 20 per cent less likely to get prostate cancer than those who never took coffee. Strikingly, they were 60 per cent less likely than the non-coffee drinkers to die of the disease. The researchers also say that decaffeinated coffee is just as effective.

17 May 2011

Lung protein appears to play a key role in smoking-related emphysema

An international research team has identified a lung protein that appears to play a key role in smoking-related emphysema and have crafted an antibody to block its activity, Indiana University scientists reported.

17 May 2011

Inhalation of hydrogen can reduce hyperoxic lung injury

Inhaling small amounts of hydrogen in addition to concentrated oxygen may help stem the damage to lung tissue that can occur when critically ill patients are given oxygen for long periods of time, according to a rat model study conducted by researchers in Pittsburgh. The study also found hydrogen initiates activation of heme-oxygenase (HO-1), an enzyme that protects lung cells.

17 May 2011

New A+PSA assay more accurately detects prostate cancer

A new test for prostate cancer that measures levels of prostate specific antigen (PSA) as well as six specific antibodies found in the blood of men with the disease was more sensitive and more specific than the conventional PSA test used today, according to a study by researchers at UCLA's Jonsson Comprehensive Cancer Center.

17 May 2011

Anti-inflammatory drug celecoxib reacts with protein and induces liver cancer cells to commit suicide

The anti-inflammatory drug celecoxib, known by the brand name Celebrex, triggers liver cancer cell death by reacting with a protein in a way that makes those cells commit suicide, according to a new study.

17 May 2011

Pediatric researchers find potential tools for controlling cytokine storm

By analyzing complex interactions of the immune system in an animal study, pediatric researchers have found potential tools for controlling a life-threatening condition called a cytokine storm that may strike children who have juvenile arthritis and other autoimmune diseases.

17 May 2011

Inflammation News and Research

Probiotic bacterial protein could offer new oral therapeutic option for inflammatory bowel disorders

Vertex Incivek receives FDA approval for treatment of chronic hepatitis C

Journal of Clinical Oncology publishes Exelixis' cabozantinib phase 1 trial results in lymphoma

Researchers discover new genes that influence severity of cystic fibrosis

Tumor necrosis factor can suppress inflammation, treat rheumatoid arthritis

Feeding SimplyThick to premature infants may cause NEC, warns FDA

FDA approves Sutent for patients with progressive neuroendocrine cancerous tumors in pancreas

Bitter cumin contains high levels of antioxidants and protects against DNA damage

Naltrexone improves clinical, inflammatory activity in Crohn's disease patients

PolyMedix's PMX-30063 compound mitigates ulcerative mucositis in pre-clinical studies

New technique offers successful bone marrow, organ transplant for patients with autoimmune diseases

Study suggests link between obesity, psoriasis and heart disease risk in children

Silodosin helps reduce chronic prostatitis in men

Workplace smoking ban improves respiratory health and reduces emergency admissions

Coffee reduces prostate cancer risk

Lung protein appears to play a key role in smoking-related emphysema

Inhalation of hydrogen can reduce hyperoxic lung injury

New A+PSA assay more accurately detects prostate cancer

Anti-inflammatory drug celecoxib reacts with protein and induces liver cancer cells to commit suicide

Pediatric researchers find potential tools for controlling cytokine storm

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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