Inflammation News and Research

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TZDs might serve as new agents for addiction treatment

Thiazolidinediones are a class of medications that are commonly prescribed to treat type-2 diabetes, while fibrates are a structurally-related class of medications that are prescribed to modulate lipid levels in both diabetic and non-diabetic patients to help reduce the risk of cardiovascular disease.

6 Apr 2011

Pervasis' PVS-30200 study data in prostate cancer presented at AACR meeting

Pervasis Therapeutics, Inc. today announced preclinical data showing positive effects of PVS-30200, the company's investigational cell therapy for the treatment of solid tumors, on controlling tumor growth and inhibiting metastases in an animal model of prostate cancer.

6 Apr 2011

Major depression linked to premature aging of immune cells: Study

Certain cases of major depression are associated with premature aging of immune cells, which may make people more susceptible to other serious illness, according to findings from a new UCSF-led study.

6 Apr 2011

Post-infection treatment with NanoViricides FluCide reduces lung lesions caused by lethal influenza infection

NanoViricides, Inc. reports that post-infection treatment with its optimized FluCide™ drug candidates resulted in dramatic reduction in the number of lung lesions that are caused by a lethal influenza virus infection. These findings were seen in the most recent H1N1 influenza animal study.

5 Apr 2011

Physical activity may moderate impact of stress on telomeres

UCSF scientists are reporting several studies showing that psychological stress leads to shorter telomeres - the protective caps on the ends of chromosomes that are a measure of cell age and, thus, health. The findings also suggest that exercise may prevent this damage.

5 Apr 2011

Certain microparticles help terminate inflammation

Scientists at Barts and The London School of Medicine and Dentistry and Harvard Medical School, Boston have found a way of mimicking the body's natural mechanism of fighting inflammation. During inflammation cells release very small particles termed 'microparticles' that retain features of their parent cell.

5 Apr 2011

Cancer cells exploit 'stress response' mechanism used by normal cells to cope with harsh, demanding conditions

Researchers at the University of California, San Diego School of Medicine say a "stress response" mechanism used by normal cells to cope with harsh or demanding conditions is exploited by cancer cells, which transmit the same stress signal to surrounding cells, triggering an inflammatory response in them that can aid tumor growth.

5 Apr 2011

ETI develops extended release SC depot formulation of NSAID drug meloxicam

Encore Therapeutics Inc. has developed a proprietary extended release subcutaneous (SC) depot formulation (ETI-511) of the NSAID drug meloxicam.

5 Apr 2011

Vitamin D can reduce estrogen receptor-positive breast cancer

In mice models of breast cancer, researchers at the Georgetown Lombardi Comprehensive Cancer Center, a part of Georgetown University Medical Center, found that vitamin D significantly reduced development of estrogen receptor-positive breast cancer both in lean and obese mice, but had no beneficial effect in estrogen receptor-negative cancer.

5 Apr 2011

Inserm Transfert, MedImmune collaborate to advance medical science research

MedImmune, the global biologics business of AstraZeneca, and Inserm Transfert, the private subsidiary of the French National Institute of Health and Medical Research, today announced a three-year strategic collaboration to advance research across a range of therapeutic areas including oncology, respiratory, inflammation, and autoimmune diseases.

5 Apr 2011

Caliper introduces novel fluorescent imaging agent for pre-clinical research

Caliper Life Sciences, Inc., a leading provider of tools and services for drug discovery, life sciences research and molecular diagnostics, today announced the launch of XenoLight RediJect COX-2 Probe, a novel fluorescent imaging agent for pre-clinical research that specifically detects the cyclooxygenase-2 biomarker noninvasively in live animal models as well as in ex vivo tissue analysis applications.

5 Apr 2011

NAA joins with organizations worldwide to raise awareness about autism

The National Autism Association joins with organizations worldwide in recognizing April as Autism Awareness month. With one in 110 children now diagnosed with autism, and autism mortality rates doubling that of the general population, NAA is once again calling upon legislators and government health agencies to declare autism a national health emergency.

4 Apr 2011

New research reveals potential treatment for HO in children, soldiers

Promising new research reveals a potentially highly effective treatment for heterotopic ossification, a painful and often debilitating abnormal buildup of bone tissue. HO comes in two main forms—one that appears in children and is congenital, another that strikes wounded military personnel and surgery patients and is triggered by severe injuries and wounds.

4 Apr 2011

Common genetic variation linked to bladder cancer risk and telomere length

A common genetic variation links to both bladder cancer risk and to the length of protective caps found on the ends of chromosomes, scientists at The University of Texas MD Anderson Cancer Center reported today at the AACR 102nd Annual Meeting.

4 Apr 2011

Study: Nanoparticles can prevent nickel-induced dermatitis

Tiny particles only billionths of a meter in diameter-about two thousand would fit across the width of a human hair-could offer big hope in a small package to the many millions of people who are allergic to the nickel in everything from jewelry to coins and cell phones, say scientists at Brigham and Women's Hospital.

4 Apr 2011

Lack of vitamin D can lead to impaired vascular health

A lack of vitamin D, even in generally healthy people, is linked with stiffer arteries and an inability of blood vessels to relax, research from the Emory/Georgia Tech Predictive Health Institute has found.

4 Apr 2011

PUMA-mediated intestinal apoptosis contributes to ulcerative colitis in humans, mice

Ulcerative colitis is an inflammatory bowel disease thought to be related to aberrant activation of the immune system in the intestine. Recent research has also suggested that regulated cell death of the intestinal epithelial cells is a contributing factor to the pathogenesis.

2 Apr 2011

Geisinger expert offers advice on how to manage child's asthma

Asthma is the leading cause of hospital visits and missed school days in children, according to the National Institute of Health. A chronic condition, pediatric asthma requires continual care to prevent serious, life-threatening asthma attacks.

1 Apr 2011

Study findings about immune systems of smoke-inhalation patients released

An award-winning Loyola University Health System study includes some unexpected findings about the immune systems of smoke-inhalation patients.

1 Apr 2011

Insulin could play a new role in fighting Alzheimer's disease: Research

A low dose of insulin has been found to suppress the expression in the blood of four precursor proteins involved in the pathogenesis of Alzheimer's disease, according to new clinical research by University at Buffalo endocrinologists. The research, published in March online in the Journal of Clinical Endocrinology and Metabolism, suggests that insulin could have a powerful, new role to play in fighting Alzheimer's disease.

1 Apr 2011