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Study uncovers how tumors backfire on neoadjuvant chemotherapy

Some patients with breast cancer receive chemotherapy before the tumor is removed with surgery. This approach, called 'neoadjuvant' therapy, helps to reduce the size of the tumor to facilitate breast-conserving surgery, and can even eradicate the tumor, leaving few or no cancerous cells for the surgeon to remove.

2 Jan 2019

Patients with stage IV disease now living a median 6.8 years after ALK+ NSCLC diagnosis

According to the National Cancer Institute, patients diagnosed with non-small cell lung cancer (NSCLC) between the years 1995 and 2001 had 15 percent chance of being alive 5 years later. For patients with stage IV disease, describing cancer that has spread to distant sites beyond the original tumor, that statistic drops to 2 percent.

2 Jan 2019

Pacemaker in the brain could help patients with epilepsy and Parkinsons

Engineers and researchers at the University of California, Berkeley have developed a neurostimulator that can act as a pacemaker within the human brain.

1 Jan 2019

MUSC researchers link higher levels of AGEs to ER-positive breast cancer risk

Poor diet and lack of exercise are associated with cancer development, but the underlying biology is not well understood. Advanced glycation end products could offer a biological link to help us understand how certain lifestyle behaviors increase cancer risk or lessen the likelihood that an anti-cancer therapy will be effective.

28 Dec 2018

New study describes various gene therapy strategies for treating Parkinson's disease

Parkinson's disease is a neurodegenerative disorder characterized by motor and nonmotor deficits majorly caused by the loss of dopaminergic cells in the Substantia Nigra pars compacta as well as the destruction of nigrostriatal pathway.

28 Dec 2018

Reducing alcohol use could help quit daily smoking habit

If quitting smoking is one of your New Year's resolutions, you might want to consider cutting back on your drinking, too.

28 Dec 2018

New research tests Co-enzyme Q10 as potential treatment for Chronic Kidney disease

Chronic Kidney disease is highly associated with all-cause mortality, Diabetic Nephropathy, cardiovascular events and hospitalization whether the patient has an existing risk or current cardiovascular disease or not.

28 Dec 2018

Scientists gain new insight into aggressive breast cancers

Scientists from Cardiff University have uncovered a protein which drives aggressive breast cancer and could be targeted for developing new and improved therapies.

27 Dec 2018

Scientists suggest need for new approach to confront side effects of common anti-cancer therapy

Results of a new study by neuroscientists at the University of Massachusetts Amherst and the University of Toronto suggest that a new treatment approach is needed - and how this may be possible - to address adverse effects of aromatase inhibitors, drugs commonly prescribed to both men and women to prevent recurrence of estrogen-positive breast cancer.

27 Dec 2018

Breast cancer drugs could tackle lung cancers resistant to targeted therapies

A class of drugs used to treat certain breast cancers could help to tackle lung cancers that have become resistant to targeted therapies, suggests a new study in mice from the Francis Crick Institute and the Institute of Cancer Research.

27 Dec 2018

Study: Reactivation of HIV-infected cells depends on its size and cell cycle

Thanks to the development of antiretroviral drugs, human immunodeficiency virus is considered a manageable chronic disease today.

27 Dec 2018

Yale researchers use arthritis medication to treat patient with disfiguring sarcoidosis

An all-Yale team of researchers successfully treated a patient with disfiguring sarcoidosis, a chronic disease that can affect multiple organs, with a drug approved for rheumatoid arthritis.

26 Dec 2018

New method of cancer stem cells activation to destroy tumors

This risky method of anti-cancer therapy was suggested by scientists of Far Eastern Federal University (FEFU). Their review of mechanisms for molecular activation of stem cells of gliomas (most widely-spread brain tumors) was approved for publishing in the Frontiers in Cellular Neuroscience journal.

26 Dec 2018

New mechanism may explain neurons shrinking in Huntington's disease

A hallmark of neurodegenerative diseases like Huntington's is the progressive death of nerve cells in the brain. The cells don't die quickly, though. They first start to disconnect from each other because their neurites -- long finger-like extensions that make connections all through the brain -- become smaller.

25 Dec 2018

Critically ill children experience muscle atrophy within one week of mechanical ventilation

Children with life-threatening respiratory failure who require mechanical ventilation in a pediatric intensive care unit commonly experience rapid muscle atrophy, according to a study published online Dec. 19, 2018, in PLOS ONE.

24 Dec 2018

Researchers identify hundreds of new genes linked to blindness in lab mice

Hundreds of new genes linked to blindness and other vision disorders have been identified in a screen of mouse strains. Many of these genes are likely important in human vision and the results could help identify new causes of hereditary blindness in patients.

24 Dec 2018

CWRU researcher receives nearly $1 million to study drug resistance mechanisms in prostate cancer

Sanjay Gupta, PhD, of Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center will receive $962,000 over three years to investigate drug resistance mechanisms in prostate cancer.

24 Dec 2018

Glial cell maturation is severely impaired in patients with Huntington's disease

The neurological disorder Huntington's disease causes behavioral and motor changes, which among other things are a result of dysfunctional maturation or formation of glial cells, the brain's support cells, researchers from the University of Copenhagen demonstrate in a new study based on mice trials.

24 Dec 2018

New treatment for adults with rare, life-threatening blood disease receives FDA approval

The U.S. Food and Drug Administration today approved Ultomiris (ravulizumab) injection for the treatment of adult patients with paroxysmal nocturnal hemoglobinuria (PNH), a rare and life-threatening blood disease.

21 Dec 2018

Study shows high rates of antibiotic overuse in patients undergoing common urological procedures

A new study suggests that antibiotics are being overused in up to 60 percent of patients undergoing common urological procedures.

21 Dec 2018

Therapy News and Research

Study uncovers how tumors backfire on neoadjuvant chemotherapy

Patients with stage IV disease now living a median 6.8 years after ALK+ NSCLC diagnosis

Pacemaker in the brain could help patients with epilepsy and Parkinsons

MUSC researchers link higher levels of AGEs to ER-positive breast cancer risk

New study describes various gene therapy strategies for treating Parkinson's disease

Reducing alcohol use could help quit daily smoking habit

New research tests Co-enzyme Q10 as potential treatment for Chronic Kidney disease

Scientists gain new insight into aggressive breast cancers

Scientists suggest need for new approach to confront side effects of common anti-cancer therapy

Breast cancer drugs could tackle lung cancers resistant to targeted therapies

Study: Reactivation of HIV-infected cells depends on its size and cell cycle

Yale researchers use arthritis medication to treat patient with disfiguring sarcoidosis

New method of cancer stem cells activation to destroy tumors

New mechanism may explain neurons shrinking in Huntington's disease

Critically ill children experience muscle atrophy within one week of mechanical ventilation

Researchers identify hundreds of new genes linked to blindness in lab mice

CWRU researcher receives nearly $1 million to study drug resistance mechanisms in prostate cancer

Glial cell maturation is severely impaired in patients with Huntington's disease

New treatment for adults with rare, life-threatening blood disease receives FDA approval

Study shows high rates of antibiotic overuse in patients undergoing common urological procedures

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