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Integrin/TGF-β1 inhibitors highly effective in attenuating COVID-19 severity

New study results suggest that integrin inhibitors have the potential to both prevent infection with SARS-CoV-2, including the Delta and Omicron variants, and to decrease TGF-β levels, resulting in a decrease in COVID-19 severity, hospitalization, and death, especially in vulnerable and unvaccinated populations.

5 Jan 2022

Study finds critical metabolic vulnerability of diffuse large B cell lymphomas

Aggressive and relatively common lymphomas called diffuse large B cell lymphomas (DLBCLs) have a critical metabolic vulnerability that can be exploited to trick these cancers into starving themselves, according to a study from researchers at Weill Cornell Medicine and Cornell's Ithaca campus.

3 Jan 2022

New treatment method leads to fewer episodes of overeating in patients with morbid obesity

Patients with morbid obesity experienced improvement in their quality of life and distinctly fewer episodes of overeating after ten weeks with a new treatment method developed at NTNU.

3 Jan 2022

New MXene-based wearable sensor may help athletes with real-time performance measurements

Ultrathin nanomaterials, known as MXenes, are poised to make it easier to monitor a person's well-being by analyzing their perspiration.

3 Jan 2022

An integrated computational methodology for COVID drug prioritization

Researchers recently published a study in the journal Briefings in Bioinformatics wherein they integrated multiple bioinformatics and cheminformatics-based methods to prioritize drugs for the treatment of COVID-19.

29 Dec 2021

Inhaled CBD shrinks glioblastoma’s size in an animal model

Inhaled CBD shrinks the size of the highly aggressive, lethal brain tumor glioblastoma in an animal model by reducing the essential support of its microenvironment, researchers report.

24 Dec 2021

Boceprevir-based molecules show high antiviral potency against SARS-CoV-2

In a study posted to the bioRxiv* pre-print server, a team of researchers conducted a structure-activity relationship study of boceprevir-based molecules to find antiviral drug candidates targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protease MPro.

22 Dec 2021

Traditional medicinal plant alleviates malaria symptoms in mice

The active plant ingredient anemonin could provide a new approach in the treatment of malaria. It was identified by researchers from Ethiopia and Germany in a buttercup that is traditionally used in some African countries as a medicinal plant to treat malaria.

20 Dec 2021

Research finds a new way for the treatment of hypoglycemia

New research has taken an important step towards the goal for a treatment for the common diabetes complication hypoglycemia, or low blood sugar.

17 Dec 2021

Identifying protein targets in SARS-CoV-2 via machine learning

A new study provides insight on using an ML-based algorithm to analyze and predict therapeutic targets in emerging pathogens with a range of mutations.

17 Dec 2021

New combined therapy shows promising results in treating triple negative breast cancer

A drug used to treat cardiac failure has shown promising results in treating triple negative breast cancer, according to Houston Methodist researchers who released results this week on a new combined therapy with the potential to improve outcomes for these hard-to-treat breast cancer patients.

15 Dec 2021

Iota-carrageenan inhibits replication of SARS-CoV-2 VOCs

Scientists have recently reported the efficacy of carrageenan against both the SARS-CoV-2 original strain as well as the Alpha, Beta, Gamma, and Delta VOCs.

13 Dec 2021

New tool to help map immune escape with SARS-CoV-2 mutations

A new study discusses a computational program that can be used to substitute for actual experimental evidence of the biologic impact of new mutations.

12 Dec 2021

Researchers discover why people with asthma have lower brain tumor risk

There's not much good that can be said about asthma, a breathing disease in which the airways become narrowed and inflamed.

11 Dec 2021

Screening FDA-approved compounds shown to possess antiviral or antimicrobial activity for SARS-CoV-2 inhibition

Researchers have screened several compounds that could show the ability to inhibit SARS-CoV-2.

10 Dec 2021

The antiviral potential of 4′-fluorouridine as an oral treatment against RSV and SARS-CoV-2

New research reports 4’-Fluorouridine (4′-FlU) as an oral antiviral against RSV and SARS-CoV-2.

7 Dec 2021

Smart transformable nanoparticles show promise for enhanced tumor theranostics

For more than three decades, biomedical nanomaterials have been successfully developed for the benefit of theranostics -- a compound term referring to the diagnoses and treatment of tumors.

7 Dec 2021

Data science proved what Pittsburgh’s Black leaders knew: Racial disparities compound covid risk

The ferocity of the covid-19 pandemic did what Black Pittsburgh — communities that make up a quarter of the city's population — thought impossible. It shook the norms.

7 Dec 2021

New protein variant underlies the ability of gastric cancers to resist chemotherapy

A new protein variant underlies the ability of gastric cancers to resist an otherwise effective family of chemotherapy drugs, according to a study by a multidisciplinary team at Weill Cornell Medicine. The results suggest a treatment strategy that could improve the prognoses of many patients with cancer.

6 Dec 2021

Higher acute stress associated with stronger alcohol craving for Black individuals

Acute stress elicits stronger alcohol craving among Black individuals compared to white individuals, reported scientists from the University of Pittsburgh School of Medicine in a paper published today in Addiction.

5 Dec 2021

Compound News and Research

Integrin/TGF-β1 inhibitors highly effective in attenuating COVID-19 severity

Study finds critical metabolic vulnerability of diffuse large B cell lymphomas

New treatment method leads to fewer episodes of overeating in patients with morbid obesity

New MXene-based wearable sensor may help athletes with real-time performance measurements

An integrated computational methodology for COVID drug prioritization

Inhaled CBD shrinks glioblastoma’s size in an animal model

Boceprevir-based molecules show high antiviral potency against SARS-CoV-2

Traditional medicinal plant alleviates malaria symptoms in mice

Research finds a new way for the treatment of hypoglycemia

Identifying protein targets in SARS-CoV-2 via machine learning

New combined therapy shows promising results in treating triple negative breast cancer

Iota-carrageenan inhibits replication of SARS-CoV-2 VOCs

New tool to help map immune escape with SARS-CoV-2 mutations

Researchers discover why people with asthma have lower brain tumor risk

Screening FDA-approved compounds shown to possess antiviral or antimicrobial activity for SARS-CoV-2 inhibition

The antiviral potential of 4′-fluorouridine as an oral treatment against RSV and SARS-CoV-2

Smart transformable nanoparticles show promise for enhanced tumor theranostics

Data science proved what Pittsburgh’s Black leaders knew: Racial disparities compound covid risk

New protein variant underlies the ability of gastric cancers to resist chemotherapy

Higher acute stress associated with stronger alcohol craving for Black individuals

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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