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Cancerous cells in aggressive childhood brain tumor work together to infiltrate the brain, shows study

Scientists have discovered that cancerous cells in an aggressive type of childhood brain tumor work together to infiltrate the brain, and this finding could ultimately lead to much needed new treatments, according to a new study published in Nature Medicine today (Monday).

2 Jul 2018

Cilia appears to play key role in formation of melanoma

Most cells in the human body have a cilium, a slender cell protuberance that picks up signals from the cell's external environment.

2 Jul 2018

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

AstraZeneca and Merck, known as MSD outside the United States and Canada, today announced that Japan's Pharmaceuticals and Medical Devices Agency has approved LYNPARZA tablets for use in patients with unresectable or recurrent BRCA-mutated, human epidermal growth factor receptor 2 -negative breast cancer who have received prior chemotherapy.

2 Jul 2018

Simple DNA test can predict risk of bad side effects to thiopurine drugs

Screening a tiny section of DNA could help East Asian patients avoid severe reactions to some medications.

2 Jul 2018

Streamlining and translating basic science discoveries into the clinic

To make sure that good ideas to enhance healthcare are not lost due to a lack of resources, a growing number of centers at Penn Medicine organize forums to pitch ideas to improve medical devices and technology, hold annual competitions to fund studies to improve patient care while keeping costs down, and sponsor seed grants for programs focused on patients who need individualized tailoring of their treatment.

2 Jul 2018

Timing may be key to evading destruction for bacteria facing antibiotics

For bacteria facing a dose of antibiotics, timing might be the key to evading destruction. In a series of experiments, Princeton researchers found that cells that repaired DNA damaged by antibiotics before resuming growth had a much better chance of surviving treatment.

30 Jun 2018

Individuals may react differently to environmental chemicals based upon genetic profile

Why do individuals respond differently to the same environment? Researchers from North Carolina State University and Oregon State University have pinpointed a genetic difference in zebrafish tied to differing responses to the same environmental chemical.

30 Jun 2018

Scientists focus on critical regulatory protein to find clues on cancer, neurodegenerative diseases

James McNew's and Michael Stern's biochemical hunt for the root cause of a rare, paralyzing genetic disorder is a 10-year quest that's taken an unexpected turn toward everyday killers such as Alzheimer's disease, cancer and aging.

30 Jun 2018

Enzyme TLK2 could serve as potential therapies for breast cancer, brain condition

In recent years, researchers have focussed on the enzyme TLK2 suspecting it of playing a main role in several diseases.

30 Jun 2018

Lamin proteins organize a cell's genetic material from the sidelines

A tremendous amount of genetic material must be packed into the nucleus of every cell--a tiny compartment.

29 Jun 2018

Study finds sex-based differences in genetic risk factors for developing gliomas

Glioma is the most common type of primary malignant brain tumor in the United States; glioblastoma being the most common type of glioma in adults.

29 Jun 2018

Computational biological models help uncover wealth of knowledge about atherosclerosis

Researchers have identified a new gene-activation pathway caused by lipids associated with coronary artery disease, a finding that could help identify new directions in research and drug development. The study was published in June in Nature Communications.

29 Jun 2018

Only one of 21 genes in BrS genetic test found to be associated with Brugada Syndrome

Clinical laboratories often rely on medical articles and public information on gene disease associations in determining the genes to include on genetic testing panels for specific conditions or the specific results to return to patients.

29 Jun 2018

Genes associated with autism interact to modulate variable symptoms of disease

Genes located in a large chromosomal aberration associated with autism interact with each other to modulate the variable symptoms of the disease, according to new research.

29 Jun 2018

Human leukemia virus increases disease risk by changing the way DNA loops inside our cells

A human virus that causes a rare form of leukemia increases the risk of disease by changing the way DNA loops inside our cells.

29 Jun 2018

Study focuses on sexual habits of fungus that causes athlete's foot

The sexual habits of Trichophyton rubrum, the fungus that causes athlete's foot and other kinds of skin and nail infections, were the focus of a study published by Brazilian scientists and international collaborators in the journal Genetics.

29 Jun 2018

Tiny snippets of genetic material may help with early detection of Alzheimer's disease

Researchers at Indiana University have found early evidence that tiny snippets of genetic material called microRNA may help with early detection of conditions such as Alzheimer's disease.

29 Jun 2018

Hearing partially restored in deaf lab mice using novel therapy

A small molecule of a drug has been successfully used to treat an inherited form of hearing loss in laboratory mice.

28 Jun 2018

Molecular brake on cell proliferation prevents DNA damage and cancer development

Researchers at Karolinska Institutet, Sweden, and the University of Sussex, England, have discovered that the process of copying DNA generates a brake signal that stalls cell division.

28 Jun 2018

MIT engineers develop simple, passive prosthetic foot that mimics natural walking

Prosthetic limb technology has advanced by leaps and bounds, giving amputees a range of bionic options, including artificial knees controlled by microchips, sensor-laden feet driven by artificial intelligence, and robotic hands that a user can manipulate with her mind.

28 Jun 2018

Genetic News and Research

Cancerous cells in aggressive childhood brain tumor work together to infiltrate the brain, shows study

Cilia appears to play key role in formation of melanoma

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

Simple DNA test can predict risk of bad side effects to thiopurine drugs

Streamlining and translating basic science discoveries into the clinic

Timing may be key to evading destruction for bacteria facing antibiotics

Individuals may react differently to environmental chemicals based upon genetic profile

Scientists focus on critical regulatory protein to find clues on cancer, neurodegenerative diseases

Enzyme TLK2 could serve as potential therapies for breast cancer, brain condition

Lamin proteins organize a cell's genetic material from the sidelines

Study finds sex-based differences in genetic risk factors for developing gliomas

Computational biological models help uncover wealth of knowledge about atherosclerosis

Only one of 21 genes in BrS genetic test found to be associated with Brugada Syndrome

Genes associated with autism interact to modulate variable symptoms of disease

Human leukemia virus increases disease risk by changing the way DNA loops inside our cells

Study focuses on sexual habits of fungus that causes athlete's foot

Tiny snippets of genetic material may help with early detection of Alzheimer's disease

Hearing partially restored in deaf lab mice using novel therapy

Molecular brake on cell proliferation prevents DNA damage and cancer development

MIT engineers develop simple, passive prosthetic foot that mimics natural walking

Genetics & Genomics - Second Edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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