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New diagnostic tools may help identify breast cancer patients who could benefit from targeted therapies

A set of emerging diagnostic tools may help identify breast cancer patients who are most likely to benefit from therapies that target important enzymes fueling a range of subtypes, including BCRA-mutated and triple negative cancers.

7 Dec 2018

Researchers use new methods to optimize treatments for tuberculosis meningitis

Although relatively rare in the United States, and accounting for fewer than 5 percent of tuberculosis cases worldwide, TB of the brain--or tuberculosis meningitis (TBM)--is often deadly, always hard to treat, and a particular threat to young children.

6 Dec 2018

$Chronic, refractory schizophrenia patients benefit from targeted cognitive training$

Chronic, refractory schizophrenia patients benefit from targeted cognitive training

Schizophrenia is among the most difficult mental illnesses to treat, in part because it is characterized by a wide range of dysfunction, from hallucinations and mood disorders to cognitive impairment, especially verbal and working memory, which can be explained in part by abnormalities in early auditory information processing.

6 Dec 2018

Study sheds new light on microtubule binding proteins and microtubule dynamics

When bacteria or viruses enter the body, proteins on their surfaces are recognized and processed to activate T cells, white blood cells with critical roles in fighting infections.

6 Dec 2018

UMGCCC uses Gammapod radiotherapy to treat breast cancer patients

Radiation oncologists at the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center are now treating patients with the GammaPod™, a new FDA-cleared radiation therapy for early-stage breast cancer.

6 Dec 2018

Elevated hormone flags liver disease in mice with serious genomic disorder

Researchers have discovered that a hormone, fibroblast growth factor 21 (FGF21), is extremely elevated in mice with liver disease that mimics the same condition in patients with methylmalonic acidemia (MMA), a serious genomic disorder.

6 Dec 2018

Breast cancer treatment more effective when determined by tumor cell count

Research published today shows that circulating tumor cell count may provide an effective indicator of appropriate treatment choice for metastatic breast cancer.

6 Dec 2018

Researchers aim to demystify bladder immunity

We know that the bladder is a poorly understood organ, critical for storing metabolic waste. What we don’t know is how this unique environment impacts bladder immunity to common diseases such as urinary tract infections and bladder cancer.

6 Dec 2018

CHOP celebrates EC approval of first and only gene therapy for patients with inherited retinal disease

Children's Hospital of Philadelphia celebrates a pivotal moment in medicine: approval by the European Commission of LUXTURNA (voretigene neparvovec), the first and only gene therapy for patients with an inherited retinal disease, last month.

6 Dec 2018

Protecting powerhouse of cells could provide better way to treat acute kidney injury

For the first time, scientists have described the body's natural mechanism for temporarily protecting the powerhouses of kidney cells when injury or disease means they aren't getting enough blood or oxygen.

6 Dec 2018

Mapping brain microglia

Microglia are known to be important to brain function. The immune cells have been found to protect the brain from injury and infection and are critical during brain development, helping circuits wire properly. They also seem to play a role in disease -- showing up, for example, around brain plaques in people with Alzheimer's.

6 Dec 2018

Financial difficulties add to patients' cancer struggle

One in five cancer patients could be experiencing financial difficulties because of their care needs, according to new research published in the Journal of Cancer Survivorship.

6 Dec 2018

Prenatal famine exposure may lead to early menopause and premature ovarian failure

Previous studies have demonstrated that fetal malnutrition can lead to adult chronic disorders such as type 2 diabetes and coronary artery disease. A new study out of China now suggests that it also can lead to early menopause and premature ovarian failure.

5 Dec 2018

Researchers succeed in converting human skin cells into blood stem cells

Researchers have succeeded in converting human skin cells into blood stem cells in an international collaboration project.

5 Dec 2018

CEASE intervention enhances delivery of smoking cessation assistance for breastfeeding mothers

A study led by MassGeneral Hospital for Children researchers demonstrates that an MGHfC-developed program designed to help the parents of pediatric patients quit smoking can increase the provision of such assistance to breastfeeding mothers.

5 Dec 2018

Scientists support original theory about pancreas regeneration

A contentious debate among diabetes researchers has surrounded the regeneration of pancreatic insulin-producing cells: not if these cells regenerate, but rather how.

5 Dec 2018

New approach turns B cells into factories that secrete sacs containing microRNAs

Cancer immunotherapy -- efforts to better arm a patient's own immune system to attack tumors -- has shown great potential for treating some cancers. Yet immunotherapy doesn't work for everyone, and some types of treatment can cause serious side effects.

5 Dec 2018

Physician-scientists present updated efficacy data on CAR T-cell gene immunotherapy

Physician-scientists from Children's Hospital of Philadelphia presented updated efficacy and safety data on Kymriah--the first-ever U.S. Food and Drug Administration approved personalized CAR T-cell gene immunotherapy for aggressive blood cancers at the 60th American Society of Hematology annual meeting, as well as first-of-its-kind research on overcoming CAR T-cell resistance.

5 Dec 2018

DHEA therapy may help prevent bone loss and increase muscle mass in older women

Women 55 and older have an increased risk of bone and muscle loss but therapy with the hormone Dehydroepiandrosterone may help prevent bone loss and increase muscle mass in older women, according to a new study led by Catherine M. Jankowski, PhD, FACSM, an exercise physiologist and associate professor at the University of Colorado College of Nursing at the Anschutz Medical Campus.

5 Dec 2018

The Lancet study: First baby born following uterus transplantation from deceased donor

Currently, uterus donation is only available for women with family members who are willing to donate. With live donors in short supply, the new technique might help to increase availability and give more women the option of pregnancy.

5 Dec 2018

Therapy News and Research

New diagnostic tools may help identify breast cancer patients who could benefit from targeted therapies

Researchers use new methods to optimize treatments for tuberculosis meningitis

Chronic, refractory schizophrenia patients benefit from targeted cognitive training

Study sheds new light on microtubule binding proteins and microtubule dynamics

UMGCCC uses Gammapod radiotherapy to treat breast cancer patients

Elevated hormone flags liver disease in mice with serious genomic disorder

Breast cancer treatment more effective when determined by tumor cell count

Researchers aim to demystify bladder immunity

CHOP celebrates EC approval of first and only gene therapy for patients with inherited retinal disease

Protecting powerhouse of cells could provide better way to treat acute kidney injury

Mapping brain microglia

Financial difficulties add to patients' cancer struggle

Prenatal famine exposure may lead to early menopause and premature ovarian failure

Researchers succeed in converting human skin cells into blood stem cells

CEASE intervention enhances delivery of smoking cessation assistance for breastfeeding mothers

Scientists support original theory about pancreas regeneration

New approach turns B cells into factories that secrete sacs containing microRNAs

Physician-scientists present updated efficacy data on CAR T-cell gene immunotherapy

DHEA therapy may help prevent bone loss and increase muscle mass in older women

The Lancet study: First baby born following uterus transplantation from deceased donor

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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