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After 35 reproductive clock ticks for men too

A new study by researchers in France has revealed that after the age of 35 men too experience a loss of fertility.

7 Jul 2008

Pregnancy rates decrease and miscarriages increase when a father is over 35

Pregnancy rates decrease and miscarriages increase when a father is over 35 years of age, a scientist will tell the 24th annual conference of the European Society of Human Reproduction and Embryology (Monday 7 July). Dr. Stephanie Belloc, of the Eylau Centre for Assisted Reproduction, Paris, France, will say that this is the first time that such a strong paternal effect on reproductive outcomes has been shown.

6 Jul 2008

UVB does more damage to DNA than UVA

As bombs burst in air this July 4, chances are that sunburn will be the red glare that most folks see - and feel. But unfortunately, even when there is no burn, the effects of the sun's ultraviolet (UV) rays can have deadly consequences.

1 Jul 2008

European researchers take lid off the genome

European researchers have made significant progress unravelling how genes are governed and why this sometimes goes wrong in disease.

15 Jun 2008

Chronic inflammation of the intestine or stomach damages DNA

Chronic inflammation of the intestine or stomach can damage DNA, increasing the risk of cancer, MIT scientists have confirmed.

2 Jun 2008

New insight into the genetics of Lou Gehrig's disease

An upcoming paper from Drs. Hidenori Ichijo and Hideki Nishitoh (The University of Tokyo) and colleagues lends new and valuable insight into the genetics of ALS.

1 Jun 2008

The emerging role of infection in Alzheimer’s

A number of chronic diseases are in fact caused by one or more infectious agents. For example, stomach ulcers are caused by Helicobacter pylori, chronic lung disease in newborns and chronic asthma in adults are both caused by Mycoplasmas and Chlamydia pneumonia, while some other pathogens have been associated with atherosclerosis. The realization that pathogens can produce slowly progressive chronic diseases has opened new lines of research into Alzheimer's disease.

25 May 2008

Research shows protecting p53 from degradation also defends metastasis-promoter

Efforts to protect the tumor-suppressor p53 could just as easily shelter a mutant version of the protein, causing cancer cells to thrive and spread rather than die, according to research by scientists at The University of Texas M. D. Anderson Cancer Center reported in the current issue of the journal Genes and Development.

22 May 2008

Scientists unravel how smoking causes cancer

Scientists have for the first time pinpointed a protein that explains how smoking can directly lead to genetic changes that cause cancer - research published in the British Journal of Cancer reveals.

15 May 2008

Vitamin D protects cells from stress that can lead to cancer

By inducing a specific gene to increase expression of a key enzyme, vitamin D protects healthy prostate cells from the damage and injuries that can lead to cancer, University of Rochester Medical Center researchers report.

13 May 2008

New chemicals shield 'genome guardian'

Cancer Research UK scientists have discovered a potent group of chemicals that protect p53 - a major anti-tumour gene - from destruction, a study published in Cancer Cell* today (Monday) reveals.

6 May 2008

Discovery of tenovins could lead to cancer cure

Scientists in Scotland have discovered a group of chemicals which protect one of the body's most important anti-cancer genes from destruction.

6 May 2008

Small molecule nutlin-3a activates an important cancer suppressor gene

By activating a cancer suppressor gene, a small molecule called nutlin-3a can block cancer cell division, according to researchers at the National Cancer Institute (NCI), part of the National Institutes of Health.

1 May 2008

New insight into the pathogenesis of neurodegeneration in Ataxia telangiectasia

An upcoming paper from Dr. David Wassarman (University of Wisconsin School of Medicine and Public Health) in the May 1 issue of G&D lends new insight into the pathogenesis of neurodegeneration in Ataxia telangiectasia.

15 Apr 2008

The good and bad side of anti-cancer compounds

Compounds known as "HDAC inhibitors" exhibit cancer-killing activities in cultured cells.

11 Apr 2008

Stem cells and cancer: cancer pathways that also control the adult stem cell population

Speaking at the UK National Stem Cell Network Annual Science Meeting in Edinburgh, Professor Alan Clarke from Cardiff University described his work to investigate a mechanism that normally drives adult stem cells to repair the intestine.

11 Apr 2008

New insight into radiation damage to DNA

A new technique for assessing the damage radiation causes to DNA indicates that the spatial arrangement of damaged sites, or lesions, is more important than the number of lesions in determining the severity of the damage.

24 Mar 2008

Cell therapies for diabetes, cancer

Therapies using stem cell transplants are advancing promising treatments for such conditions as Alzheimer's Disease, neurological diseases and spinal cord injury, and heart disease.

20 Mar 2008

Experimental cancer drug MI-219 promising in preclinical studies

Researchers have long searched for a novel cancer drug that activates a certain protein to kill tumor cells.

4 Mar 2008

Protein protects lung cancer cells from efforts to fix or kill them

A protein that helps lung cancer cells thrive appears to do so by blocking healthy cells' ability to fix themselves when radiation or chemicals such as nicotine damage their DNA, according to a University of Florida study to be published Friday (Feb. 29) in the journal Molecular Cell.

28 Feb 2008