Malignant News and Research

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Novel biomarker can distinguish between benign and malignant lung nodules

Researchers report a newly developed biomarker was 98% effective at distinguishing between benign and malignant lung nodules in a recent multicentre clinical trial.

18 Apr 2018

Research reveals immune suppressive role of soluble antibodies in tumor progression

Wistar researchers have found that soluble antibodies promote tumor progression by inducing accumulation of myeloid-derived suppressor cells (MDSCs) in pre-clinical cancer models. Results were published online in Cancer Immunology Research.

13 Apr 2018

Oxygen 'nanobubbles' could help enhance cancer therapies and hasten wound healing

A Purdue University-patented technology shows promise in using microscopic bubbles filled with oxygen to help with various medical treatments, including improving cancer therapeutics and helping wounds heal faster.

13 Apr 2018

Researchers unlock new way to use cell's nanostructures as disease biomarkers

Researchers at the University of Sydney have established a method to identify individual nanoparticles released by human cells, opening the way for them to become diagnostic tools in the early-detection of cancers, dementia and kidney disease.

13 Apr 2018

Biomarker panel can guide future therapeutic decisions for glioma patients

In an article published April 10th in the journal Cell Reports, researchers at the University of São Paulo describe a biomarker panel that could tell physicians which patients diagnosed with glioma, a type of brain cancer, will tend to progress to a more aggressive form of the disease in the event of relapse.

10 Apr 2018

Scripps Florida researchers awarded $2.875 million to destroy common form of leukemia

Christoph Rader, PhD, associate professor at the Florida campus of The Scripps Research Institute, has been awarded a $2.875 million, five-year grant from the National Cancer Institute to develop unique antibody-drug conjugates engineered to eradicate one of the most common forms of leukemia, chronic lymphocytic leukemia

10 Apr 2018

Newly discovered predictive biomarkers could help assess level of glioma recurrence risk

Researchers have identified specific predictive biomarkers that could help assess the level of risk for recurrence in patients with malignant glioma. The study, led by Henry Ford Health System's Department of Neurosurgery and Department of Public Health Sciences, was published today in Cell Reports.

10 Apr 2018

Researchers uncover mechanism critical to keeping blood stem cells functional

Hematopoietic stem cells, that form mature blood cells, require a very precise amount of protein to function - and defective regulation of protein production is common in certain types of aggressive human blood cancers.

6 Apr 2018

Research finds breast lesions in transmen undergoing mastectomy

The number of transmen seeking gender-confirming surgery has risen in the past decade. In a paper published in the British Journal of Surgery analyzing breast tissue from 344 transmen undergoing mastectomy, breast lesions--either benign or malignant--were present in 166 individuals (48.3%).

5 Apr 2018

Older Americans are hooked on vitamins despite scarce evidence they work

When she was a young physician, Dr. Martha Gulati noticed that many of her mentors were prescribing vitamin E and folic acid to patients. Preliminary studies in the early 1990s had linked both supplements to a lower risk of heart disease.

4 Apr 2018

Researchers develop self-healing material for bone implants

Researchers from the Center for Composite Materials at the National University of Science and Technology MISiS have recently developed a self-healing material for bone implants.

4 Apr 2018

Ionizing radiation can reduce stiffness of tumor cell microenvironment

Nearly half of all cancer patients receive radiation therapy to curb the growth of malignant cells. But little is known about how ionizing radiation affects the extracellular matrix (ECM), a patchwork of proteins and other biomolecules that surrounds cells and plays a vital role in their shape, movement and signaling functions.

3 Apr 2018

FDA-approved drug for chemical abortion shows promise for treatment of vestibular schwannoma

Massachusetts Eye and Ear researchers have shown that mifepristone, a drug currently FDA-approved for chemical abortion, prevents the growth of vestibular schwannoma cells. This sometimes-lethal intracranial tumor typically causes hearing loss and tinnitus

3 Apr 2018

Combined treatment prolongs survival in mouse models of malignant mesothelioma

Combined treatment with two cancer immunotherapy drugs - one a novel immune modulator and one that focuses and activates the antitumor immune response - significantly prolonged survival in mouse models of the aggressive cancer malignant mesothelioma.

2 Apr 2018

UTSW study reveals mechanisms underlying development of Sonic Hedgehog medulloblastoma

A delicate balance during brain development could have profound implications for understanding and treating medulloblastoma, the most common malignant brain tumor affecting children.

29 Mar 2018

Researchers discover important features of tumor cells that may help fight cancer

A research team led by Mónica Bettencourt Dias, from Instituto Gulbenkian de Ciência, discovered important features of cancer cells that may help clinicians fighting cancer.

28 Mar 2018

FDA-approved inhibitors could be repurposed to target ARID1A-mutant ovarian cancers

Wistar researchers have found rationale for repurposing a class of antitumor compounds called HDAC inhibitors, already approved by the FDA for the treatment of diseases such as leukemia, as a new therapeutic option for ovarian cancer with mutations in the ARID1A gene.

27 Mar 2018

Malignant News and Research

Novel biomarker can distinguish between benign and malignant lung nodules

Research reveals immune suppressive role of soluble antibodies in tumor progression

Oxygen 'nanobubbles' could help enhance cancer therapies and hasten wound healing

Researchers unlock new way to use cell's nanostructures as disease biomarkers

Biomarker panel can guide future therapeutic decisions for glioma patients

Scripps Florida researchers awarded $2.875 million to destroy common form of leukemia

Newly discovered predictive biomarkers could help assess level of glioma recurrence risk

Researchers uncover mechanism critical to keeping blood stem cells functional

Research finds breast lesions in transmen undergoing mastectomy

Older Americans are hooked on vitamins despite scarce evidence they work

Researchers develop self-healing material for bone implants

Ionizing radiation can reduce stiffness of tumor cell microenvironment

FDA-approved drug for chemical abortion shows promise for treatment of vestibular schwannoma

Combined treatment prolongs survival in mouse models of malignant mesothelioma

UTSW study reveals mechanisms underlying development of Sonic Hedgehog medulloblastoma

Researchers discover important features of tumor cells that may help fight cancer

FDA-approved inhibitors could be repurposed to target ARID1A-mutant ovarian cancers

Screening strategies could reduce multiple myeloma prevalence, mortality

New analysis describes how childhood obesity 'pandemic' promotes cancer

Native-state microscope could make disease diagnoses timelier and surgeries more effective

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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