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Researchers reveal the role of hypothalamic astrocytes in obesity-related hypertension

Researchers have succeeded for the first time in demonstrating the role of hypothalamic astrocytes in obesity-related hypertension.

15 Jun 2021

Low-fiber, high-fat diets cause significant shifts in the gut microbiome

Changes to gut microbiome are known to impact metabolic health. Physiologists at Laval University in Canada have discovered that diets containing low fiber and high fat cause significant shifts in the gut microbiome - the collection of bacteria, viruses, fungi and other multicellular microorganisms that live in the gastrointestinal system.

15 Jun 2021

Nanoparticle-based therapy alleviates pulmonary hypertension in mouse model of rare lung disease

The disease is so rare and complex that its acronym is hard to pronounce. But for infants unlucky enough to be born with this lung disease, the outcome is usually fatal.

14 Jun 2021

Intranasal monoclonal SARS-CoV-2 antibody therapy shows promise in preclinical trials

A new study, released as a preprint on the bioRxiv* server, presents a new monoclonal antibody (MAb) called DZIF-10c that powerfully neutralizes SARS-CoV-2, including the current variants of concern (VOCs). With high bioavailability in the lungs and wide distribution in the body, the antibody was able to prevent SARS-CoV-2 infection in mice after intranasal administration.

14 Jun 2021

What makes the elderly more susceptible to SARS-CoV-2 infection?

Why is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19 (coronavirus disease 2019), biased towards infecting the aged population? A recently published study by Italian scientists linked aging, DNA damage, telomere shortening, and increased levels of angiotensin-converting enzyme 2 (ACE2) to this relationship.

13 Jun 2021

Metformin prevents pulmonary or lung inflammation in animals infected with SARS-CoV-2

Metformin is a widely prescribed blood sugar-lowering drug. It is often used as an early therapy (in combination with diet and lifestyle changes) for type 2 diabetes, which afflicts more than 34 million Americans.

11 Jun 2021

Macrophages can aid tumor growth by distracting cancer-killing CD8+ T cells

A Ludwig Cancer Research study adds to growing evidence that immune cells known as macrophages inhabiting the body cavities that house our vital organs can aid tumor growth by distracting the immune system's cancer-killing CD8+ T cells.

11 Jun 2021

In vivo protection from emerging SARS-CoV-2 variants by protein nanoparticle vaccine

Researchers in the United States have developed a new coronavirus disease 2019 (COVID-19) vaccine that induced potent neutralizing antibodies against variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in animal models.

10 Jun 2021

Scientists develop new method for single-cell lineage tracing of metastatic cancer

It's often cancer's spread, not the original tumor, that poses the disease's most deadly risk.

10 Jun 2021

Study reveals how high fat diets can cause intestinal and colon cancer

For decades, physicians and dieticians have urged people to limit their intake of high fat foods, citing links to poor health outcomes and some of the leading causes of death in the U.S., such as diabetes, heart disease and cancer.

9 Jun 2021

New cell-penetrating peptide may protect against life-threatening microbial inflammation

A cell-penetrating peptide developed by researchers at Vanderbilt University Medical Center can prevent, in an animal model, the often-fatal septic shock that can result from bacterial and viral infections.

9 Jun 2021

Researchers identify novel gene that controls sleep/wake cycle in mice

That internal nagging feeling that drives you to seek sleep at night and wake in the morning to eat, work, and play, is, it turns out, genetic, and it's not just in people.

9 Jun 2021

High sugar intake from childhood could lead to long-term health problems

Children who consume too much sugar could be at greater risk of becoming obese, hyperactive, and cognitively impaired, as adults, according to the results of a new study of mice led by QUT and published by Frontiers in Neuroscience.

8 Jun 2021

Testing placental hormone levels can help identify candidates for pregnancy complications

Women who will develop potentially life-threatening disorders during pregnancy can be identified early when hormone levels in the placenta are tested, a new study has shown.

8 Jun 2021

Immunomodulatory therapies for nephrological autoimmune diseases may help treat severe COVID-19

Various viruses and bacteria have long been known to cause autoimmune diseases where there is such a predisposition. This phenomenon also seems to play a major role in SARS-CoV-2, especially in severe courses.

8 Jun 2021

Researchers develop promising stem cell therapy to treat type 1 diabetes

Type 1 diabetes, which arises when the pancreas doesn't create enough insulin to control levels of glucose in the blood, is a disease that currently has no cure and is difficult for most patients to manage.

8 Jun 2021

Restoring gut microbes can improve antibiotic-induced dysbiosis and prevent colitis in mice

A new study at the University of Chicago has determined that restoring a single microbial species -- Bacteroides sp. CL1-UC (Bc) -- to the gut microbiome at a key developmental timepoint can prevent antibiotic-induced colitis in a mouse model of the condition.

7 Jun 2021

Mouse Model News and Research

Researchers reveal the role of hypothalamic astrocytes in obesity-related hypertension

Low-fiber, high-fat diets cause significant shifts in the gut microbiome

Nanoparticle-based therapy alleviates pulmonary hypertension in mouse model of rare lung disease

Intranasal monoclonal SARS-CoV-2 antibody therapy shows promise in preclinical trials

What makes the elderly more susceptible to SARS-CoV-2 infection?

Metformin prevents pulmonary or lung inflammation in animals infected with SARS-CoV-2

Macrophages can aid tumor growth by distracting cancer-killing CD8+ T cells

In vivo protection from emerging SARS-CoV-2 variants by protein nanoparticle vaccine

Scientists develop new method for single-cell lineage tracing of metastatic cancer

Study reveals how high fat diets can cause intestinal and colon cancer

New cell-penetrating peptide may protect against life-threatening microbial inflammation

Researchers identify novel gene that controls sleep/wake cycle in mice

High sugar intake from childhood could lead to long-term health problems

Testing placental hormone levels can help identify candidates for pregnancy complications

Immunomodulatory therapies for nephrological autoimmune diseases may help treat severe COVID-19

Researchers develop promising stem cell therapy to treat type 1 diabetes

Restoring gut microbes can improve antibiotic-induced dysbiosis and prevent colitis in mice

Discovery offers a potential new pathway to treat hypertension

New therapeutic approach developed to treat psoriatic arthritis

Mice study shows that Western diet can lead to NASH, liver fibrosis

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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