Signaling Pathway News and Research

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Researchers present data on ARQ 092 at 2013 AACR Annual Meeting

Researchers presented data today on ARQ 092, an AKT inhibitor in Phase 1 clinical development by ArQule, Inc. at the AACR Annual Meeting held in Washington, D.C., April 6-10, showing that this novel, oral agent inhibits the AKT pathway and has a manageable safety profile in an ongoing Phase 1 clinical trial.

10 Apr 2013

American Society of Hematology announces first recipients of ASH Bridge Grants

The American Society of Hematology, the world's largest professional organization dedicated to the causes and treatment of blood disorders, today announced the first recipients of the ASH Bridge Grants, a new award program designed to help hematologists continue their critical blood disease research amid severe funding reductions for the National Institutes of Health.

9 Apr 2013

Discovery of new signalling pathway creates hope for hormone therapy resistance

A team of international cancer researchers led by Dr. Mathieu Lupien at the Princess Margaret Cancer Centre, University Health Network, has identified the signalling pathway that is over-activated in estrogen receptor (ER)-positive breast cancer cells that are resistant to hormone therapies such as tamoxifen, aromatase inhibitors or fulvestrant.

2 Apr 2013

Research findings could lead to new targets for treating inflammatory disorders

Researchers at UC Davis have shown how the innate immune system distinguishes between dangerous pathogens and friendly microbes. Like burglars entering a house, hostile bacteria give themselves away by breaking into cells. However, sensing proteins instantly detect the invasion, triggering an alarm that mobilizes the innate immune response.

2 Apr 2013

Sildenafil may also serve as weight loss aid, shows new research

Although sildenafil is best known for promoting erections, it may also serve as a weight loss aid by coaxing our bodies to store more healthy "brown fat" relative to unhealthy "white fat" than it would otherwise do on its own.

2 Apr 2013

Neurological researchers study promising new treatment for deadly brain tumors

A promising new treatment for deadly brain tumors taken orally with minimal side effects is being studied by neurological researchers at Rush University Medical Center, Chicago.

28 Mar 2013

Study shows why certain drugs that interact with serotonin receptors have harmful effects

A team including scientists from The Scripps Research Institute (TSRI), the University of North Carolina at Chapel Hill and the Chinese Academy of Sciences has determined and analyzed the high-resolution atomic structures of two kinds of human serotonin receptor.

25 Mar 2013

Scientists identify potential treatment for idiopathic pulmonary fibrosis

Investigators at the University of Alabama at Birmingham (UAB) have unlocked another piece of the puzzle surrounding idiopathic pulmonary fibrosis, an often fatal lung disease with no cure and no effective treatments.

25 Mar 2013

Study on how Hedgehog signal defines cell-cell interaction receives $747,000 grant

While many researchers believe that the Hedgehog (Hh) signaling pathway, which transmits information to embryonic cells for proper development and is important for regeneration, may actually regulate cell-cell adhesion and segregation - there isn't any evidence.

16 Mar 2013

IU researchers awarded $3.2 million grant to develop new treatments for pancreatic cancer

Two Indiana University researchers have been awarded a multi-year, $3.2 million grant to develop and improve therapies for pancreatic cancer, the fourth leading cause of cancer death in the United States.

14 Mar 2013

Scientists reveal genetic activity that led to development of wings in fruit flies

Scientists have delved deeper into the evolutionary history of the fruit fly than ever before to reveal the genetic activity that led to the development of wings - a key to the insect's ability to survive.

12 Mar 2013

Research illuminates why stimulating environment may protect against Alzheimer's disease

"Use it or lose it." The saying could apply especially to the brain when it comes to protecting against Alzheimer's disease.

7 Mar 2013

Scientists report successful blocking of tumor development in genetic mouse model of human cancer

UT Southwestern Medical Center scientists report the first successful blocking of tumor development in a genetic mouse model of an incurable human cancer.

6 Mar 2013

Global inhibition of all Notch signals would not be safe after bone marrow transplantation

Bone marrow transplant is a key treatment for patients with leukemia, lymphoma, multiple myeloma and other blood disorders. University of Michigan researchers have discovered that inhibiting a signaling pathway in some of the transplanted cells could prevent the most serious potential complications of the procedure, a conflict between the transplanted cells and the recipient's own tissue called graft-versus-host disease.

2 Mar 2013

NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth

Myocardial hypertrophy, a thickening of the heart muscle, is an adaptation that occurs with increased stress on the heart, such as high blood pressure. As the heart muscle expands, it also requires greater blood flow to maintain access to oxygen and nutrients, necessitating an expansion of the cardiac vasculature.

2 Mar 2013

Researchers identify novel signaling pathway responsible for neuroprotective activity of parkin

Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich identify a novel signal transduction pathway, which activates the parkin gene and prevents stress-induced neuronal cell death.

2 Mar 2013

Junk food during pregnancy changes development of opioid signaling pathway in the baby's brain

Here's another reason why a healthy diet during pregnancy is critical to the future health of your children: New research published in the March 2013 issue of The FASEB Journal, suggests that pregnant mothers who consume junk food actually cause changes in the development of the opioid signaling pathway in the brains of their unborn children.

1 Mar 2013

Calcium channel risk allele linked to executive function in bipolar disorder

Researchers have found an allele in a voltage-gated calcium gene that is associated with an increased risk for poor executive function in patients with bipolar disorder.

27 Feb 2013

Researchers discover that tympanic border cells can enable hearing

Researchers at the Stanford University School of Medicine have identified a group of progenitor cells in the inner ear that can become the sensory hair cells and adjacent supporting cells that enable hearing.

27 Feb 2013

Promyleocytic leukemia gene goes up significantly in post treatment of mTOR inhibitors

Glioblastoma, the most common and lethal form of brain tumor in adults, is challenging to treat because the tumors rapidly become resistant to therapy. As cancer researchers are learning more about the causes of tumor cell growth and drug resistance, they are discovering molecular pathways that might lead to new targeted therapies to potentially treat this deadly cancer.

27 Feb 2013

Signaling Pathway News and Research

Researchers present data on ARQ 092 at 2013 AACR Annual Meeting

American Society of Hematology announces first recipients of ASH Bridge Grants

Discovery of new signalling pathway creates hope for hormone therapy resistance

Research findings could lead to new targets for treating inflammatory disorders

Sildenafil may also serve as weight loss aid, shows new research

Neurological researchers study promising new treatment for deadly brain tumors

Study shows why certain drugs that interact with serotonin receptors have harmful effects

Scientists identify potential treatment for idiopathic pulmonary fibrosis

Study on how Hedgehog signal defines cell-cell interaction receives $747,000 grant

IU researchers awarded $3.2 million grant to develop new treatments for pancreatic cancer

Scientists reveal genetic activity that led to development of wings in fruit flies

Research illuminates why stimulating environment may protect against Alzheimer's disease

Scientists report successful blocking of tumor development in genetic mouse model of human cancer

Global inhibition of all Notch signals would not be safe after bone marrow transplantation

NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth

Researchers identify novel signaling pathway responsible for neuroprotective activity of parkin

Junk food during pregnancy changes development of opioid signaling pathway in the baby's brain

Calcium channel risk allele linked to executive function in bipolar disorder

Researchers discover that tympanic border cells can enable hearing

Promyleocytic leukemia gene goes up significantly in post treatment of mTOR inhibitors

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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