DNA Damage News and Research

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Electronic structure of single DNA molecules revealed

Utilizing a technique that combines low temperature measurements and theoretical calculations, Hebrew University of Jerusalem scientists and others have revealed for the first time the electronic structure of single DNA molecules.

28 Feb 2008

High zinc status in lung cells slows growth and induces DNA

Researchers at the University of Maryland at College Park have discovered that Normal Human Bronchial Epithelial (NHBE) cells cultured in medium with elevated zinc level, at the high end of plasma zinc attainable by oral supplementation, demonstrated inhibition of cell growth, up-regulation of growth arrest and DNA damage-induced gene (Gadd45) mRNA and protein expression, and blockage of G2/M cell cycle progression.

26 Feb 2008

Oncoproteins double-team and destroy vital tumor-suppressor

Two previously unconnected cancer-promoting proteins team up to ambush a critical tumor suppressor by evicting it from the cell's nucleus and then marking it for death by a protein-shredding mechanism, a team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in the Feb. 10 issue of Nature Cell Biology.

17 Feb 2008

Scientists find how PARP-1 protein binds to genes and regulates human genome

Out of chaos, control: Cornell University molecular biologists have discovered how a protein called PARP-1 binds to genes and regulates their expression across the human genome.

8 Feb 2008

New anticancer drugs may block HSP90-IP6K2 protein interaction involved in cell death

Johns Hopkins researchers have discovered a previously unsuspected mechanism of cell death that may afford a new way to find and develop stronger yet less-harmful anticancer drugs.

23 Jan 2008

Low vitamin E levels associated with physical decline in elderly

Researchers at Yale School of Medicine have found that a low concentration of vitamin E in the blood is linked with physical decline in older persons.

23 Jan 2008

Connection between vitamin E and subsequent decline in physical function for older adults

Low serum concentration of vitamin E, an indication of poor nutrition, is associated with physical decline for older persons, according to a study in the January 23 issue of JAMA: The Journal of the American Medical Association.

23 Jan 2008

New clues about BRCA1 role in breast cancer

A breast cancer gene's newly discovered role in repairing damaged DNA may help explain why women who inherit a mutated copy of the gene are at increased risk for developing both breast and ovarian cancer.

17 Jan 2008

Genetic evolution of tumours according to their growth dynamics.

A study co-directed by the Universidad Complutense de Madrid and La Paz hospital in Madrid identifies a protein of high expression in cells located at the tumour boundary that could play an essential role in the evolution of tumours and their invasive potential.

11 Jan 2008

Breast cancer gene mutation more common in Hispanic, young black women

A genetic mutation already known to be more common in Ashkenazi Jewish breast cancer patients is also prevalent in Hispanic and young African-American women with breast cancer, according to one of the largest, multiracial studies of the mutation to date.

28 Dec 2007

Stem cells train heart following heart attack

Following a heart attack, part of the heart tissue dies. It is still not possible to restore the scar tissue arising as a result of this. The majority of stem cell researchers attempt to make new heart muscle cells from stem cells.

27 Nov 2007

Alcohol and second-hand smoke a deadly combo

According to a new study the combination of alcohol and second-hand smoke can cause damage to the heart.

26 Nov 2007

Study looks at effects of smoking and breathing second-hand smoke along with drinking

Tobacco smoke-filled air is bad for cardiovascular health, and drinking alcohol at the same time only makes it worse, according to researchers at the University of Alabama at Birmingham (UAB).

21 Nov 2007

Carbon monoxide counteracts one side-effect of an anti-cancer drug

Doxorubicin (DOX) is a red-colored anticancer drug that carries serious side effects for the heart, including cardiac muscle deterioration (cardiomyopathy) and scar tissue accumulation in the heart (fibrosis).

21 Nov 2007

Melatonin could actually be hurting you at night!

What do you do when a naturally occurring hormone in your body turns against you? What do you do when that same hormone - melatonin - is a popular supplement you take to help you sleep?

16 Nov 2007

Manipulation of MOF enzyme may make tumors more sensitive to radiation therapy

To make tumors more sensitive to the killing power of radiation is a key aspiration for many radiation oncologists. Researchers at Washington University School of Medicine in St. Louis have uncovered new information that leads them closer to that goal.

5 Nov 2007