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Dramatic changes in the way the FDA address patient safety are needed

Food and Drug Administration policies prevent pharmaceutical manufacturers from informing patients about potentially fatal toxicities that occur with some cancer drugs -- policies that should be revised immediately, according to Northwestern University researchers.

20 Dec 2004

Study on first new potential drug for tuberculosis in 40 years

454 Life Sciences, a majority-owned subsidiary of CuraGen Corporation, announced today that its proprietary whole genome sequencing technology was used by scientists at Johnson & Johnson Pharmaceutical Research & Development L.L.C. (J&JPRD) to help understand the basis of tuberculosis drug resistance.

20 Dec 2004

How radiation therapy is used to safely and effectively treat various cancers

To help cancer patients and their families better understand their treatment options before making a decision, the American Society for Therapeutic Radiology and Oncology has published seven patient information brochures that explain how radiation therapy is used to safely and effectively treat various cancers.

16 Dec 2004

Millennium Pharmaceuticals discovers protein biomarkers that could play a role in the early detection of rheumatoid arthritis

Researchers at Millennium Pharmaceuticals today announced the discovery of a panel of protein biomarkers that could play a role in the early detection, prognosis and monitoring of rheumatoid arthritis (RA).

14 Dec 2004

Scientists have identified a novel anti-tuberculosis (TB) compound

Scientists at Johnson & Johnson Pharmaceutical Research and Development have identified a novel anti-tuberculosis (TB) compound that works better and faster than the current standard of care in mouse models of TB infection.

14 Dec 2004

False positive cancer screening tests result not only in anxiety but also additional economic costs

Cancer screening tests can frequently produce false positive outcomes that may result not only in anxiety but also additional economic costs as well, according to research conducted by scientists at the Henry Ford Health System, Detroit, Mich., and published in the December issue of Cancer Epidemiology, Biomarkers & Prevention

14 Dec 2004

Link found between bisphosphonates and a serious bone disease called osteonecrosis of the jaw

Doctors at Long Island Jewish (LIJ) Medical Center recently discovered a link between a common chemotherapy drug and a serious bone disease called osteonecrosis of the jaw (ONJ).

13 Dec 2004

Start today of human tests for a preventive vaccine against the respiratory disease SARS

Powerful research tools that speed up vaccine development have led to the start today of human tests for a preventive vaccine against the respiratory disease SARS. The disease killed hundreds of people around the world before it was brought under control in 2003 with aggressive conventional public health measures.

13 Dec 2004

Molecular Achilles heel in the organism that causes pneumonia

Scientists have found a “molecular Achilles heel” in the organism that causes pneumonia, providing a target for the development of a new class of antibiotics that could eventually eradicate the disease.

13 Dec 2004

Novel anti-rejection protocol should allow major improvement efficacy and quality of life after intestinal and multivisceral transplants

Transplant researchers at the University of Pittsburgh's Thomas E. Starzl Transplantation Institute have dramatically improved intestinal transplant graft survival, and reduced rejection and infection rates by successfully using a novel immunosuppression minimization protocol, thus improving patients' overall quality of life and avoiding the use of several anti-rejection drugs, which can cause serious infections and major complications.

13 Dec 2004

Study of safety issues surrounding the medical use of cannabis has just been launched

A first-of-its-kind study of safety issues surrounding the medical use of cannabis has just been launched. Known as the COMPASS study (Cannabis for the management of pain: assessment of safety study), the research initiative will follow 1400 chronic pain patients, 350 of whom use cannabis as part of their pain management strategy, for a one-year period.

8 Dec 2004

Defect in one of nature's oldest proteins may be an underlying cause in human miscarriages

University of Rochester scientists studying a vital protein called Serum Response Factor (SRF) in mice have learned new and unexpected facts about SRF's role in early cardiovascular development, and how a defect in this gene may be an underlying cause in human miscarriages.

8 Dec 2004

Children are more vulnerable than adults to the adverse effects of air pollution

Children are more vulnerable than adults to the adverse effects of air pollution for several reasons. First, children have increased exposure to many air pollutants because they spend more time outside, have higher breathing rates and higher levels of physical activity compared with adults.

7 Dec 2004

Cardiac surgery mortality rates continue to decline

New Jersey’s sixth cardiac surgery report card shows that mortality rates continued to decline in 2001 to the lowest levels since reporting began in the state, Health and Senior Services Commissioner Clifton R. Lacy, M.D., announced yesterday.

7 Dec 2004

Novel mutagenesis screen used to identify genetic suppressors of thrombosis

Researchers using a novel sensitized ENU (N-ethyl-N-nitrosourea, a carcinogen-induced animal tumor model established to grow malignant and benign tumors) mutagenesis (induction of mutation) screen in laboratory mice have developed a promising approach to genetic screening that can increase the likelihood of identifying dominant suppressors of thrombosis.

6 Dec 2004

New advances in sickle cell disease

Excruciating pain episodes, recurrent pneumonias, strokes, severe infections, chronic hemolytic anemia, and secondary pulmonary hypertension are common complications of sickle cell disease, a life-threatening inherited defect in blood that causes normally disc-shaped red blood cells to take on a sickle shape.

6 Dec 2004

Children with sickle cell disease who are at risk for a stroke need ongoing blood transfusions to reduce their risk

“This important study shows the value of continuing periodic blood transfusions in preventing the serious and debilitating consequences of stroke,” says NHLBI Acting Director Barbara Alving. “At the same time, there are risks of chronic transfusions and the decision to continue with this treatment must be made on a case-by-case basis.”

6 Dec 2004

Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Modern research is delving deep into the human genome to find the answers to medical mysteries and, hopefully, cures for the most deadly diseases. According to four new studies presented during the 46th Annual Meeting of the American Society of Hematology

5 Dec 2004

A gallery of highly-specific, gene and protein “mug shots” of cancer types would be a powerful for oncologists

Doctors would like to diagnose malignancies rapidly by matching them with highly-specific genetic “mug shots” based on the presence of characteristic mRNAs or proteins. This kind of specificity would facilitate screening and early detection, and would potentially allow targeted treatments specific to each type of cancer

4 Dec 2004

Study focused on patients with chemotherapy-related anemia

Findings from an interim analysis of a new study comparing the hemoglobin response rates of Epoetin alfa and darbepoetin alfa in the treatment of chemotherapy-related anemia were published in the November 15, 2004 issue of the Medical Journal 'Blood' as part of the American Society of Hematology 46th Annual Meeting and Exposition.

4 Dec 2004

Lungs News and Research

Dramatic changes in the way the FDA address patient safety are needed

Study on first new potential drug for tuberculosis in 40 years

How radiation therapy is used to safely and effectively treat various cancers

Millennium Pharmaceuticals discovers protein biomarkers that could play a role in the early detection of rheumatoid arthritis

Scientists have identified a novel anti-tuberculosis (TB) compound

False positive cancer screening tests result not only in anxiety but also additional economic costs

Link found between bisphosphonates and a serious bone disease called osteonecrosis of the jaw

Start today of human tests for a preventive vaccine against the respiratory disease SARS

Molecular Achilles heel in the organism that causes pneumonia

Novel anti-rejection protocol should allow major improvement efficacy and quality of life after intestinal and multivisceral transplants

Study of safety issues surrounding the medical use of cannabis has just been launched

Defect in one of nature's oldest proteins may be an underlying cause in human miscarriages

Children are more vulnerable than adults to the adverse effects of air pollution

Cardiac surgery mortality rates continue to decline

Novel mutagenesis screen used to identify genetic suppressors of thrombosis

New advances in sickle cell disease

Children with sickle cell disease who are at risk for a stroke need ongoing blood transfusions to reduce their risk

Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

A gallery of highly-specific, gene and protein “mug shots” of cancer types would be a powerful for oncologists

Study focused on patients with chemotherapy-related anemia

The ultimate guide to lung research tools and protocols eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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