Genes News and Research

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Researchers identify new therapeutic target for treating most common form of eye cancer

Researchers at the University of California, San Diego School of Medicine have identified a therapeutic target for treating the most common form of eye cancer in adults. They have also, in experiments with mice, been able to slow eye tumor growth with an existing FDA-approved drug.

30 May 2014

Blood gene expression profile identifies patients with elevated risk of cardiovascular death

A study of 338 patients with coronary artery disease has identified a gene expression profile associated with an elevated risk of cardiovascular death. Used with other indicators such as biochemical markers and family history, the profile - based on a simple blood test - may help identify patients who could benefit from personalized treatment and counseling designed to address risk factors.

30 May 2014

New insights into egg selection may have broad implications for women's health, fertility

A woman's supply of eggs is a precious commodity because only a few hundred mature eggs can be produced throughout her lifetime and each must be as free as possible from genetic damage.

30 May 2014

Reduced glomerular filtration rate is independent risk factor for renal and urothelial cancer

Researchers who investigated the level of kidney function and subsequent cancer risk in more than one million adults have found that reduced glomerular filtration rate (GFR) — a key measure of reduced kidney function and chronic kidney disease (CKD) — is an independent risk factor for renal and urothelial cancer but not other cancer types.

30 May 2014

New approach could lead to more effective HIV vaccine

Using a genetically modified form of the HIV virus, a team of University of Nebraska-Lincoln scientists has developed a promising new approach that could someday lead to a more effective HIV vaccine.

30 May 2014

Female mice deprived of dietary zinc before conception experience fertility problems

Female mice deprived of dietary zinc for a relatively short time before conception experienced fertility and pregnancy problems and had smaller, less-developed fetuses than mice that ingested zinc during the same times, according to researchers in Penn State's College of Agricultural Sciences.

30 May 2014

New powerful tool helps identify disease-causing mutations in families

Scientists at the University of Utah (U of U), the University of Texas MD Anderson Cancer Center in Houston and colleagues have developed a powerful tool called pVAAST that combines linkage analysis with case control association to help researchers and clinicians identify disease-causing mutations in families faster and more precisely than ever before.

30 May 2014

Study reveals how BTK mutation triggers drug resistance in CLL patients

A multi-institutional team of researchers has pinpointed exactly what goes wrong when chronic lymphocytic leukemia (CLL) patients develop resistance to ibrutinib, a highly effective, precisely targeted anti-cancer drug.

29 May 2014

Researchers create initial catalog of human proteome, identify 193 novel proteins

Striving for the protein equivalent of the Human Genome Project, an international team of researchers has created an initial catalog of the human "proteome," or all of the proteins in the human body.

29 May 2014

UT Southwestern researchers identify protein critical to the spread of deadly cancer cells

UT Southwestern Medical Center cancer researchers have identified a protein critical to the spread of deadly cancer cells and determined how it works, paving the way for potential use in diagnosis and eventually possible therapeutic drugs to halt or slow the spread of cancer.

29 May 2014

Initial biopsy with epigenetic test rules out prostate cancer up to 88%

A multicenter team of researchers report that a commercial test designed to rule out the presence of genetic biomarkers of prostate cancer may be accurate enough to exclude the need for repeat prostate biopsies in many — if not most — men.

29 May 2014

Researchers design commercial test to rule out presence of genetic biomarkers of prostate cancer

29 May 2014

Study defines specific genetic mechanism that explains some of schizophrenia's heritability

The overall number and nature of mutations—rather than the presence of any single mutation—influences an individual's risk of developing schizophrenia, as well as its severity, according to a discovery by Columbia University Medical Center researchers published in the latest issue of Neuron.

29 May 2014

Ebola research: an interview with Professor Easton, University of Warwick

Ebola virus belongs to a group of viruses that have been known for some time. It was first isolated as a result of an infection in a primate, in a monkey colony, in monkeys that were being used for research in the Philippines.

28 May 2014

Scientists collect new data on how "tumor suppressor" gene works

Scientists armed with a supercomputer and a vast trove of newly collected data on the body's most potent "tumor suppressor" gene have created the best map yet of how the gene works, an accomplishment that could lead to new techniques for fighting cancers, which are adept at disabling the gene in order to thrive.

28 May 2014

Study provides insight into genetic causes of cleft lip and cleft palate

Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, have identified how a specific stretch of DNA controls far-off genes to influence the formation of the face.

28 May 2014

Biologists show bioelectrical signals control tumors arising from cancer-causing genes, fatty acid

Developmental biologists at Tufts University, using a tadpole model, have shown that bioelectrical signals from distant cells control the incidence of tumors arising from cancer-causing genes and that this process is impacted by levels of a common fatty acid produced by bacteria found in the tadpole and also in humans.

28 May 2014

Researchers study why male babies generally have worse outcomes than females

Sexual inequality between boys and girls starts as early as in the mother's womb - but how and why this occurs could be a key to preventing higher rates of preterm birth, stillbirth and neonatal death among boys.

28 May 2014

Genetic variant linked to sudden cardiac death leads to protein overproduction in heart cells

A genetic variant linked to sudden cardiac death leads to protein overproduction in heart cells, Johns Hopkins scientists report. Unlike many known disease-linked variants, this one lies not in a gene but in so-called noncoding DNA, a growing focus of disease research.

28 May 2014

Findings may help medical researchers identify effective drug targets for triple negative breast cancer

The suppression of two genes reduce breast cancer tumor formation and metastasis by interfering with blood vessel formation and recruitment, report scientists from Houston Methodist and five other institutions in the Proceedings of the National Academy of Sciences (now online).

28 May 2014

Genes News and Research

Researchers identify new therapeutic target for treating most common form of eye cancer

Blood gene expression profile identifies patients with elevated risk of cardiovascular death

New insights into egg selection may have broad implications for women's health, fertility

Reduced glomerular filtration rate is independent risk factor for renal and urothelial cancer

New approach could lead to more effective HIV vaccine

Female mice deprived of dietary zinc before conception experience fertility problems

New powerful tool helps identify disease-causing mutations in families

Study reveals how BTK mutation triggers drug resistance in CLL patients

Researchers create initial catalog of human proteome, identify 193 novel proteins

UT Southwestern researchers identify protein critical to the spread of deadly cancer cells

Initial biopsy with epigenetic test rules out prostate cancer up to 88%

Researchers design commercial test to rule out presence of genetic biomarkers of prostate cancer

Study defines specific genetic mechanism that explains some of schizophrenia's heritability

Ebola research: an interview with Professor Easton, University of Warwick

Scientists collect new data on how "tumor suppressor" gene works

Study provides insight into genetic causes of cleft lip and cleft palate

Biologists show bioelectrical signals control tumors arising from cancer-causing genes, fatty acid

Researchers study why male babies generally have worse outcomes than females

Genetic variant linked to sudden cardiac death leads to protein overproduction in heart cells

Findings may help medical researchers identify effective drug targets for triple negative breast cancer

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