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Study of men with inherited DNA repair mutations opens new therapeutic avenues in prostate cancer

Selected by the American Society of Clinical Oncology to first outing during its Genitourinary Cancers Symposium, Translating Evidence to Multidisciplinary Care, February 8 - 10 (San Francisco, USA), Joaquin Mateo, Principal Investigator of VHIO's recently created Prostate Cancer Translational Research Group, will today reveal findings from a retrospective and international study showing for the first time that patients with inherited DNA repair mutations benefit from standard therapies in a similar way to other metastatic prostate cancer patients.

9 Feb 2018

Research funded by NIH grant aims to discover crucial role of 'invisible' cells

Neurons are the star of the show in brain science, but they don't work alone to process information. In new research funded by a $1.9 million grant from the National Institutes of Health, a team at MIT's Picower Institute for Learning and Memory aims to discover the likely crucial role of the supporting cast member with a stellar-sounding name: the astrocyte.

9 Feb 2018

Alzheimer’s study on mice reveals important mechanism behind neural hyperactivity

Alzheimer´s disease is the key cause of dementia in elderly patients. Those affected develop deficiencies in their abilities to learn, think logically, communicate, and to master the challenges of everyday life.

9 Feb 2018

Undergraduate researcher discovers genes linked to glioblastoma

When Leland Dunwoodie, an undergraduate researcher in biochemistry, approached his PI about wanting to start research on "some human stuff" in the spring of 2016, he didn't imagine it would lead to the discovery of 22 genes that are implicated in glioblastoma, the most aggressive type of brain cancer.

9 Feb 2018

Lab-grown eggs could combat infertility

Researchers have successfully developed human eggs in a laboratory in a major scientific first.

9 Feb 2018

Using CRISPR To Produce Induced Pluripotent Stem Cells

An interview with Dr. Sheng Ding about using a modified version of the CRISPR-Cas9 system to produce induced pluripotent stem cells.

9 Feb 2018

Study reveals the link between genetic variations and major psychiatric disorders

Psychiatric disorders including schizophrenia, autism, and bipolar disorder share common molecular characteristics, despite variations in gene expression.

9 Feb 2018

DNA plays unexpected architectural role in shaping cells, study finds

As a basic unit of life, the cell is one of the most carefully studied components of all living organisms. Yet details on basic processes such as how cells are shaped have remained a mystery.

8 Feb 2018

Cholesterol and other lipids in the blood play role in many diseases

Lipids are fatty molecules that play important signaling and storage roles in the body, but having an excess of some lipids, like cholesterol, is a risk factor for many metabolic diseases.

8 Feb 2018

HDAC6 inhibition could be promising therapeutic approach for peripheral neuropathies

Inhibiting HDAC6 improves the structural stability of cells and protects against neuronal damage. Leuven research uncovered that targeting this mechanism could be a promising therapeutic approach for peripheral neuropathies, whether due to Charcot-Marie-Tooth disease (CMT) or as a side effect of chemotherapy.

8 Feb 2018

International research collaboration finds genetic mutation linked to Crohn's disease

A genetic mutation was found to be associated with Crohn's disease. The discovery was made by international research collaboration and was published in the prestigious journal Science Translational Medicine.

8 Feb 2018

Scientists identify special pair of RNA scissors with many functions

CRISPR/Cas systems are known as promising "gene scissors" in the genome editing of plants, animals, and microorganisms by targeting specific regions in their DNA - and perhaps they can even be used to correct genetic defects.

8 Feb 2018

Myriad’s myRisk Hereditary Cancer test finds inherited gene mutations in more than 12% of prostate cancer patients

Myriad Genetics, Inc., a leader in molecular diagnostics and personalized medicine, announced today that results from a large 1,162 patient study of the Myriad myRisk Hereditary Cancer test will be featured during the poster presentation at the 2018 Genitourinary Cancer Symposium in San Francisco, Calif.

8 Feb 2018

Positivity keeps dementia at bay finds study

Persons who have developed positive attitudes towards life and aging are less likely to develop dementia finds a new study. Becca Levy from the Yale School of Public Health, USA, and colleagues have published the reports of this encouraging study in the latest issue of the journal PLOS ONE.

8 Feb 2018

Researchers identify presence of ER gene fusion proteins in treatment-resistant breast cancer

At Magee-Womens Research Institute and UPMC Hillman Cancer Center, a large team of clinical and laboratory researchers dedicated to understanding treatment resistance in the most common form of breast cancer have identified a new genetic change in the estrogen receptor that contributes to therapy resistance.

7 Feb 2018

Novel genetic mutations may explain link between high HDL cholesterol and reduced heart disease risk

Researchers at the University of Maryland School of Medicine have uncovered genetic mutations that may explain why people with high levels of high-density lipoprotein (HDL) cholesterol, the "good cholesterol," have a reduced risk of coronary heart disease.

7 Feb 2018

Study provides insight into mechanisms for increased male susceptibility to ASD

Exposure to androgens (male hormones) during brain development alters genes related to autism spectrum disorder (ASD), according to a new study published in Biological Psychiatry.

7 Feb 2018

IU scientists take important step to fight against hepatitis B with 'virus-cracking' molecules

Indiana University researchers have made an important step forward in the design of drugs that fight the hepatitis B virus, which can cause liver failure and liver cancer.

7 Feb 2018

Novel technology platform for custom designing bacteriophages

Bacteriophages, known informally as phages, are viruses that can attack and kill specific bacteria. They occur everywhere in the natural world. Precisely because they are matched to just one specific type of bacteria, researchers and medics hope that phages can be engineered to combat certain bacterial infections.

7 Feb 2018

New CRISPR gene-editing technique can correct majority of mutations that cause DMD

Scientists have developed a CRISPR gene-editing technique that can potentially correct a majority of the 3,000 mutations that cause Duchenne muscular dystrophy (DMD) by making a single cut at strategic points along the patient's DNA, according to a study from UT Southwestern Medical Center.

6 Feb 2018

Genetic News and Research

Study of men with inherited DNA repair mutations opens new therapeutic avenues in prostate cancer

Research funded by NIH grant aims to discover crucial role of 'invisible' cells

Alzheimer’s study on mice reveals important mechanism behind neural hyperactivity

Undergraduate researcher discovers genes linked to glioblastoma

Lab-grown eggs could combat infertility

Using CRISPR To Produce Induced Pluripotent Stem Cells

Study reveals the link between genetic variations and major psychiatric disorders

DNA plays unexpected architectural role in shaping cells, study finds

Cholesterol and other lipids in the blood play role in many diseases

HDAC6 inhibition could be promising therapeutic approach for peripheral neuropathies

International research collaboration finds genetic mutation linked to Crohn's disease

Scientists identify special pair of RNA scissors with many functions

Myriad’s myRisk Hereditary Cancer test finds inherited gene mutations in more than 12% of prostate cancer patients

Positivity keeps dementia at bay finds study

Researchers identify presence of ER gene fusion proteins in treatment-resistant breast cancer

Novel genetic mutations may explain link between high HDL cholesterol and reduced heart disease risk

Study provides insight into mechanisms for increased male susceptibility to ASD

IU scientists take important step to fight against hepatitis B with 'virus-cracking' molecules

Novel technology platform for custom designing bacteriophages

New CRISPR gene-editing technique can correct majority of mutations that cause DMD

Sequencing & Genomics: Elevating Science and Healthcare eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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