Cell Nucleus News and Research

RSS

AMPK may regulate epigenetic mechanism: Research

AMP-activated protein kinase, or AMPK, is a master regulator protein of metabolism that is conserved from yeast to humans. When a cell is low on fuel, AMPK shuts down processes that use energy and turns on processes that produce energy.Biologists have been studying how AMPK works for several decades and know that once it is activated, AMPK turns on a large number of genes by passing the "make more energy" message through numerous signaling cascades in the cell. What was not known, until now, was that AMPK also works via an epigenetic mechanism to slow down or stop cell growth.

17 Jul 2010

Studying retrovirus assembly can help new drug development for infection control

How a retrovirus, like HIV, reproduces and assembles new viruses is different than previously thought, according to Penn State College of Medicine researchers. Understanding the steps a virus takes for assembly could allow development of a way to prevent the spread of retroviral diseases. The team studied a chicken virus called Rous sarcoma virus that causes cancer in chickens and is similar to HIV.

16 Jul 2010

New use of green fluorescent protein

Scientists are reporting discovery of a way to help proteins such as the new generation of protein-based drugs -- sometimes heralded as tomorrow's potential "miracle cures" -- get past the biochemical "Entrance Forbidden" barrier that keeps them from entering cells and doing their work. The new technique, described in the monthly journal, ACS Chemical Biology, represents a new use for an engineered form of green fluorescent protein, the topic of the 2008 Nobel Prize in Chemistry that is one of the most important research tools in biosciences.

15 Jul 2010

Report investigates clear cell ICC

Intrahepatic cholangiocarcinoma is a cancer of the bile duct in the liver. The clear cell subtype of ICC is a rare cancer; until now, only 8 cases have been reported. The number of reports is so small that a detail description of clear cell ICC is valuable.

8 Jul 2010

Study findings may provide insight into extreme behaviors associated with rejection

The pain and anguish of rejection by a romantic partner may be the result of activity in parts of the brain associated with motivation, reward and addiction cravings, according to a study published in the July issue of the Journal of Neurophysiology.

7 Jul 2010

Rejection by romantic partner associated with brain's motivation, reward and addiction craving centers

Researchers have linked rejection by a romantic partner to brain activity associated with motivation, reward and addiction cravings, according to a study published in the July issue of the Journal of Neurophysiology. Lucy Brown, Ph.D., clinical professor in the Saul R. Korey Department of Neurology and of neuroscience at Albert Einstein College of Medicine of Yeshiva University, is the corresponding author of the study.

7 Jul 2010

Scientists discover nanoparticle to deliver DNA with minimum toxic effect

In lab experiments, the researchers have found that this device, a vector, is able to deliver DNA deeply enough into a cell to allow genetic material to be activated - a critical step in gene therapy. This vector is between 2 - and 10 times more effective than other experimental materials, according to the research.

7 Jul 2010

Histone H1 phosphorylation involved in control of ribosomal RNA gene transcription

A protein that helps pack DNA into the cell nucleus has an important role in regulating gene activity, scientists report. The researchers found that the protein, histone H1, also takes part in the formation of ribosomes, the cellular workbenches on which all proteins are made.

2 Jul 2010

Key mechanism present in virgin olive oil protects body against breast cancer: Researchers

Researchers at Universitat Autònoma de Barcelona, led by Dr Eduard Escrich, have discovered a key mechanism by which virgin olive oil, in contrast to other vegetable oils, protects the body against breast cancer.

30 Jun 2010

Herniated disk can cause low back and leg pain in adults

A literature review, led by Dr. Joseph Lee, published in the June 2010 issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS) suggests that a herniated disk is one of the most frequent causes of low back and leg pain in adults, but surgery is not for everyone. Between 60 and 80 percent of people will experience low back pain at some point in their lives.

30 Jun 2010

An innovative genetic prediction algorithm

A University of Toledo doctoral candidate in biomedical sciences recently combined the inspiration he received from his grandfather, values learned from his mother, insights gleaned from his mentors and processing power tapped from a supercomputer to unlock a few of the many secrets of the human genome.

29 Jun 2010

Literature review discusses herniated disks and treatment options for low back pain

29 Jun 2010

Gene therapy holds promise in treating cancer, cardiovascular and neurodegenerative diseases

EUREKA project E! 3371 Gene Transfer Agents has made great advances in the development of novel non-viral carriers able to introduce genetic material into the target cells.

25 Jun 2010

Researchers find way to get beneficial effects of estrogen without increasing woman's risk of cancer

Researchers at UT Southwestern Medical Center have pinpointed a set of biological mechanisms through which estrogen confers its beneficial effects on the cardiovascular system, independent of the hormone's actions on cancer. Their investigation suggests that drugs targeting a specific subpopulation of estrogen receptors found outside the cell nucleus might activate the cardiovascular benefits of estrogen without increasing cancer risk.

24 Jun 2010

Neurologix announces positive results from Phase 2 trial of NLX-P101 for advanced PD

Neurologix, Inc., today announced positive results in a Phase 2 trial of its investigational gene therapy for advanced Parkinson's disease, NLX-P101. Study participants who received NLX-P101 experienced statistically significant and clinically meaningful improvements in off-medication motor scores compared to control subjects who received sham surgery.

22 Jun 2010

Gladstone Institute researcher to receive Kyoto Prize in Advanced Technology

The non-profit Inamori Foundation (President: Dr. Kazuo Inamori) today announced that Dr. Shinya Yamanaka will receive its 26th annual Kyoto Prize in Advanced Technology, which for 2010 focuses on the fields of Biotechnology and Medical Technology. Dr. Yamanaka, 47, will receive the award for his pioneering work in developing a technology to generate pluripotent stem cells that does not require the use of human embryos.

18 Jun 2010

Sulindac shuts down cancer cell growth, initiates cell death: Study

Without knowing exactly why, scientists have long observed that people who regularly take non-steroidal anti-inflammatory drugs like aspirin have lower incidences of certain types of cancer. Now, in a study appearing in Cancer Cell on June 15, investigators at Sanford-Burnham Medical Research Institute and their colleagues have figured out how one NSAID, called Sulindac, inhibits tumor growth.

15 Jun 2010

CNVs increases patients' susceptibility to severe sepsis

Genetic makeup has been identified as a key factor leading to the development of sepsis, a systemic inflammatory reaction that occurs during infection. Sepsis is considered severe when associated with organ dysfunction.

14 Jun 2010

Some commonly used drugs cause bone loss: New research

New research helps to explain why some commonly used drugs come with a serious downside: They up your odds of breaking a bone. The drugs in question, glucocorticoids (e.g. cortisone and prednisone) and the insulin sensitizer rosiglitazone work through entirely different mechanisms as therapies for inflammatory diseases and diabetes respectively, and two studies in the June issue of Cell Metabolism now show that they lead to bone loss in different ways too.

9 Jun 2010

Researchers one step closer to understand how activity outside of nucleus determines cell's behavior

With the rapid and continuous advances in biotechnology, scientists are better able to see inside the nucleus of a cell to unlock the secrets of its genetic material. However, what happens outside of the nucleus has, in many ways, remained a mystery. Now, researchers with the National Institutes of Health are closer to understanding how activity outside of the nucleus determines a cell's behavior.

5 Jun 2010

Cell Nucleus News and Research

AMPK may regulate epigenetic mechanism: Research

Studying retrovirus assembly can help new drug development for infection control

New use of green fluorescent protein

Report investigates clear cell ICC

Study findings may provide insight into extreme behaviors associated with rejection

Rejection by romantic partner associated with brain's motivation, reward and addiction craving centers

Scientists discover nanoparticle to deliver DNA with minimum toxic effect

Histone H1 phosphorylation involved in control of ribosomal RNA gene transcription

Key mechanism present in virgin olive oil protects body against breast cancer: Researchers

Herniated disk can cause low back and leg pain in adults

An innovative genetic prediction algorithm

Literature review discusses herniated disks and treatment options for low back pain

Gene therapy holds promise in treating cancer, cardiovascular and neurodegenerative diseases

Researchers find way to get beneficial effects of estrogen without increasing woman's risk of cancer

Neurologix announces positive results from Phase 2 trial of NLX-P101 for advanced PD

Gladstone Institute researcher to receive Kyoto Prize in Advanced Technology

Sulindac shuts down cancer cell growth, initiates cell death: Study

CNVs increases patients' susceptibility to severe sepsis

Some commonly used drugs cause bone loss: New research

Researchers one step closer to understand how activity outside of nucleus determines cell's behavior

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

Latest News