Endocrine News and Research

RSS

Increasing levels of FGF21 hormone protects against loss of immune function in the elderly

A hormone that extends lifespan in mice by 40% is produced by specialized cells in the thymus gland, according to a new study by Yale School of Medicine researchers. The team also found that increasing the levels of this hormone, called FGF21, protects against the loss of immune function that comes with age.

12 Jan 2016

Millendo signs license agreement, secures funding to test new drugs for treatment of endocrine disorders

Millendo Therapeutics, a University of Michigan startup company, announced an exclusive license agreement with AstraZeneca for the worldwide development and commercialization rights to test a new compound, MLE4901, for the treatment of polycystic ovary syndrome.

6 Jan 2016

New oral breast cancer drug has potential to combat other types of cancer

Palbociclib, a new oral drug whose efficacy in combating breast cancer has been demonstrated alone and in combination with endocrine therapy, also has potential to combat other types of cancer, according to a literature review and additional original research conducted by experts at the Abramson Cancer Center in the University of Pennsylvania published this month in JAMA Oncology.

30 Dec 2015

Microencapsulation method can help overcome challenges in pancreatic islet transplantation

A microencapsulation method, developed by OIST researchers, can help to overcome major challenges in pancreatic islet transplantation.

26 Dec 2015

Combination therapy can help overcome endocrine resistance in women with advanced breast cancer

Data collected in Japanese and Korean patients included in the global PALOMA3 trial provides evidence that combining palbociclib with fulvestrant is an effective strategy to overcome endocrine resistance in women with hormone receptor positive (HR+), HER2 negative (HER2-) advanced breast cancer.

20 Dec 2015

Multiple small doses of targeted radiation therapy more effective at destroying pituitary gland tumors

A recent patient study at Houston Methodist Hospital proved that multiple small doses of highly focused radiation therapy is safer and more effective than a single larger dose of radiation at destroying pituitary gland tumors.

18 Dec 2015

High testosterone levels in women may increase uterine fibroid risk

Women who have high levels of both testosterone and estrogen in midlife may face a greater risk of developing benign tumors on the uterus called uterine fibroids than women with low levels of the hormones, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

16 Dec 2015

$Active individuals may need to maintain higher vitamin D levels to reduce risk of stress fractures$

Active individuals may need to maintain higher vitamin D levels to reduce risk of stress fractures

Vitamin D plays a crucial role in ensuring appropriate bone density. Active individuals who enjoy participating in higher impact activities may need to maintain higher vitamin D levels to reduce their risk of stress fractures, report investigators in The Journal of Foot & Ankle Surgery.

14 Dec 2015

Adjuvant chemotherapy not beneficial for patients with luminal A subtype of breast cancer

Premenopausal women whose invasive breast cancers were of the luminal A subtype had comparable 10-year disease-free survival rates regardless of whether or not they received adjuvant chemotherapy, according to data from the phase III DBCG77B clinical trial presented at the 2015 San Antonio Breast Cancer Symposium, held Dec. 8-12.

11 Dec 2015

Study reveals why anti-hormone therapy tamoxifen works better in some women than others

The anti-hormone therapy tamoxifen can reduce breast cancer recurrence by about half in women with hormone-sensitive breast cancer. But it works better in some women than others. Researchers are not sure why.

11 Dec 2015

Endocrine-disrupting chemicals pose threat to male reproductive health

The birth rate is declining in all industrialised countries, and socioeconomic factors and women's age are not solely to blame. Male reproductive health and environmental factors are also significant, as concluded in a new scientific review article.

11 Dec 2015

Environmental and lifestyle factors damage men's reproductive health

Environmental and lifestyle factors are damaging men's reproductive health and may be playing a large role in decreasing fertility rates in industrialized countries, a new study in Physiological Reviews reports. Socioeconomic influences and female reproductive health cannot solely be blamed for higher incidences of infertility, the study supports.

10 Dec 2015

Adjuvant denosumab improves disease-free survival for postmenopausal women with early-stage, HR+ breast cancer

Adding denosumab to adjuvant aromatase inhibitor therapy improved disease-free survival for postmenopausal patients with early-stage, hormone receptor (HR)-positive breast cancer, according to results from the phase III ABCSG-18 clinical trial presented at the 2015 San Antonio Breast Cancer Symposium, held Dec. 8-12.

9 Dec 2015

Children born to mothers with PCOS at increased risk of developing autism

Children born to mothers with polycystic ovarian syndrome, PCOS, are at an increased risk of developing autism spectrum disorders, according to a new epidemiological study from Sweden's Karolinska Institutet. The findings, which are published in the journal Molecular Psychiatry, support the notion that exposure to sex hormones early in life may be important for the development of autism in both sexes.

8 Dec 2015

Finding may lead to better understanding of male genital birth defects

University of Florida Health researchers have identified genes that are disrupted by abnormal hormone signaling at crucial points during development, a finding that may lead to a better understanding of how the most common male genital birth defects arise in humans.

24 Nov 2015

Sildenafil drug improves insulin sensitivity in people at risk for diabetes

The drug sildenafil, sold as Viagra and other brand names, improves insulin sensitivity in people at risk for diabetes, researchers at Vanderbilt University Medical Center reported today.

19 Nov 2015

Viking submits IND application to FDA to conduct VK2809 Phase 2 study in patients with LDL-C and fatty liver disease

Viking Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on the development of novel, first-in-class or best-in-class therapies for metabolic and endocrine disorders, today announced that it has submitted an investigational new drug (IND) application to the U.S. Food and Drug Administration to conduct a Phase 2 study of VK2809 in patients with hypercholesterolemia and fatty liver disease.

17 Nov 2015

City of Hope awarded NIH grant to study potential link between environmental factors and breast cancer

The National Institutes of Health has awarded City of Hope a five-year, $4.8 million grant to study the possible role of chemicals in the environment in the development of breast cancer during the menopausal transition in women.

6 Nov 2015

Study explores benefits of breast cancer adjuvant therapies

After breast cancer surgery, women are prescribed adjuvant (or follow-up) therapies such as chemotherapy and endocrine drugs to reduce the risk of the cancer returning. It's been assumed that the treatment effects of these therapies remain constant over time, but a new study from the Cancer Therapy & Research Center (CTRC) at The University of Texas Health Science Center at San Antonio suggests the opposite is true.

4 Nov 2015

$Viking begins VK5211 Phase 2 trial in patients recovering from hip fracture$

Viking begins VK5211 Phase 2 trial in patients recovering from hip fracture

Viking Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on the development of novel, first-in-class or best-in-class therapies for metabolic and endocrine disorders, today announced the initiation of dosing in the company's Phase 2 clinical trial of VK5211 in patients who recently suffered a hip fracture.

3 Nov 2015

Endocrine News and Research

Increasing levels of FGF21 hormone protects against loss of immune function in the elderly

Millendo signs license agreement, secures funding to test new drugs for treatment of endocrine disorders

New oral breast cancer drug has potential to combat other types of cancer

Microencapsulation method can help overcome challenges in pancreatic islet transplantation

Combination therapy can help overcome endocrine resistance in women with advanced breast cancer

Multiple small doses of targeted radiation therapy more effective at destroying pituitary gland tumors

High testosterone levels in women may increase uterine fibroid risk

Active individuals may need to maintain higher vitamin D levels to reduce risk of stress fractures

Adjuvant chemotherapy not beneficial for patients with luminal A subtype of breast cancer

Study reveals why anti-hormone therapy tamoxifen works better in some women than others

Endocrine-disrupting chemicals pose threat to male reproductive health

Environmental and lifestyle factors damage men's reproductive health

Adjuvant denosumab improves disease-free survival for postmenopausal women with early-stage, HR+ breast cancer

Children born to mothers with PCOS at increased risk of developing autism

Finding may lead to better understanding of male genital birth defects

Sildenafil drug improves insulin sensitivity in people at risk for diabetes

Viking submits IND application to FDA to conduct VK2809 Phase 2 study in patients with LDL-C and fatty liver disease

City of Hope awarded NIH grant to study potential link between environmental factors and breast cancer

Study explores benefits of breast cancer adjuvant therapies

Viking begins VK5211 Phase 2 trial in patients recovering from hip fracture

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

Latest News