Signaling Pathway News and Research

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Missing gene plays role in autism

It is estimated that three to six out of every 1,000 children in the United States have autism - and the number of diagnosed cases is rising.

8 Feb 2009

What your mother did when she was a child may have an effect on your memory

A new study by researchers from Rush University Medical Center and Tufts University School of Medicine using mice indicate that a child's memory and the severity of learning disorders may be affected by what his or her mother did when she was a child.

3 Feb 2009

New clues to pancreatic cells' destruction in diabetes

Researchers have found what appears to be a major culprit behind the loss of insulin-producing beta cells from the pancreases of people with diabetes, a critical event in the progression of the disease.

3 Feb 2009

Century old drug clofazimine shows potential for multiple sclerosis

A century-old drug that failed in its original intent to treat tuberculosis but has worked well as an antileprosy medicine now holds new promise as a potential therapy for multiple sclerosis and other autoimmune diseases.

2 Feb 2009

Scientists develop sophisticated model to help researchers apply physics and mathematics concepts to cancer

Biology exists in a physical world. That's a fact cancer researchers are beginning to recognize as they look to include concepts of physics and mathematics in their efforts to understand how cancer develops -- and how to stop it.

2 Feb 2009

Discovery of mechanism for dental pain

Researchers at Oregon Health & Science University's School of Dentistry have discovered a novel function of the peptide known as Nerve Growth Factor (NGF) in the development of the trigeminal nerve.

8 Jan 2009

Onyx Pharmaceuticals acquires license option on novel JAK2 inhibitors from S*BIO

Onyx Pharmaceuticals, Inc. has announced that it has acquired an option to license rights to SB1518, an orally available, potent, and selective inhibitor of Janus Kinase 2 (JAK2), and SB1578, also a JAK2 inhibitor, from S*BIO Pte Ltd based in Singapore.

6 Jan 2009

Extract from grapes kills lab leukemia cells, proving value of natural compounds

An extract from grape seeds forces laboratory leukemia cells to commit cell suicide, according to researchers from the University of Kentucky.

1 Jan 2009

High-fat diet can disrupt our biological clock

Indulgence in a high-fat diet can not only lead to overweight because of excessive calorie intake, but also can affect the balance of circadian rhythms - everyone's 24-hour biological clock, Hebrew University of Jerusalem researchers have shown.

29 Dec 2008

Scientists find gene that is a powerful predictor of colon cancer metastasis

Cancer researchers have identified a gene which enables them to predict for the first time with high probability if colon cancer is going to metastasize.

22 Dec 2008

Possible new therapeutic target for pancreatic cancer

A possible new therapeutic target for pancreatic cancer, the most lethal form of human cancer, has been identified in the proteins whose DNA recipe comes from gene, "Seven-In-Absentia," according to researchers at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 in San Francisco.

14 Dec 2008

Cause of uveal melanoma discovered, most common eye cancer

A University of British Columbia geneticist has discovered a gene mutation that can cause the most common eye cancer - uveal melanoma.

10 Dec 2008

Cellular 'brakes' may slow memory process in aging brains

University of Florida researchers may have discovered why some brain cells necessary for healthy memory can survive old age or disease, while similar cells hardly a hairsbreadth away die.

10 Dec 2008

Brain deletion of FK506-binding protein enhances repetitive behaviors in mice

A new study reveals a link between dysregulation of a common signaling pathway and repetitive behaviors similar to those associated with multiple neurological and neurodegenerative disorders including, autism spectrum disorders, obsessive compulsive disorder, schizophrenia, and Huntington's disease.

10 Dec 2008

Genetic signature may lead to better treatments for pediatric liver cancers

Scientists have identified a genetic signature that is remarkably effective at predicting the prognosis of an aggressive liver cancer in children.

8 Dec 2008

Genetic breakdown in Fanconi anemia may have link to HPV-associated cancer

A genetic malfunction that causes DNA instability in people with the blood disorder Fanconi anemia may put them at high risk for squamous cell carcinomas linked to human papillomavirus (HPV), according to a study posted online ahead of print by Oncogene.

3 Dec 2008