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Researchers receive $6 million NIH grant to improve treatment for Chagas disease

Scientists at The University of Texas at El Paso have received nearly $6 million from the National Institutes of Health to improve treatment and develop new diagnostic tools to assess post-therapeutic outcomes for patients with Chagas disease.

29 Aug 2018

Hesperos receives SBIR grant to create ‘human-on-a-chip’ model to mimic Alzheimer's disease

Hesperos, Inc., announced today the receipt of a NIH Phase I Small Business Innovation Research grant from the National Institutes of Health National Institute on Aging to help create a new multi-organ "human-on-a-chip" model that can realistically mimic the biology of Alzheimer's Disease and the effects of potential new therapies under realistic human physiological conditions.

29 Aug 2018

Researchers uncover why some cancers grow faster than others

University of Toronto researchers have uncovered why some cancers grow faster than others. The team led by Liliana Attisano, Professor in U of T's Donnelly Centre for Cellular and Biomolecular Research, has identified a protein called NUAK2, which is produced by cancer cells to boost their proliferation and whose presence in tumors is associated with poor disease prognosis.

29 Aug 2018

Researchers discover reason why many bladder cancer patients do not respond to immunotherapy

Mount Sinai researchers have discovered that a particular type of cell present in bladder cancer may be the reason why so many patients do not respond to the groundbreaking class of drugs known as PD-1 and PD-L1 immune checkpoint inhibitors, which enable the immune system to attack tumors.

29 Aug 2018

Research shows proteomics can be used to predict evolution of triple negative breast cancer

The rarest, but also the most aggressive and hard to treat form of breast cancer, is known as triple negative. For this type of cancer, researchers have so far been unable to identify markers that can classify patients by prognosis or probability of responding to different treatments.

29 Aug 2018

Researchers discover mechanism that steers growth of cancer cells in melanoma and liver cancer

Melanoma and liver cancer are becoming more widespread in Europe and the US. Whilst both diseases progress very differently, they are among the types of cancer which are most likely to be fatal in the Western world.

29 Aug 2018

Study suggests new strategies for using cell metabolism to treat cancer

Researchers at the University of Cincinnati College of Medicine have discovered that cell metabolism plays an important role in the ability of cells to start a survival program called autophagy, an unwanted side effect of some anti-cancer drugs that helps some tumor cells dodge treatment and eventually regrow into new tumors.

29 Aug 2018

Researchers develop better options to treat peripheral artery disease

Cristina Sabliov, LSU Biological and Agricultural Engineering professor, and Tammy Dugas, professor in the LSU School of Veterinary Medicine's Department of Comparative Biomedical Sciences, have joined forces to fight peripheral artery disease, or PAD, an ailment affecting 8 million Americans.

29 Aug 2018

New mathematical model helps understand transmission of drug-resistant malarial parasites

A new mathematical model for malaria shows how competition between parasite strains within a human host reduces the odds of drug resistance developing in a high-transmission setting.

29 Aug 2018

Researchers find how NF2 gene mutations lead to out-of-control cellular proliferation

A team of Massachusetts General Hospital Cancer Center researchers has determined one way that mutations in a gene involved in a rare, hereditary cancer syndrome lead to out-of-control cellular proliferation.

29 Aug 2018

Drug used for chest pain does not decrease chance of first occurrence of ventricular arrhythmias

A clinical trial of more than 1,000 patients with implantable cardioverter defibrillators found that the drug ranolazine was safe but didn't significantly decrease the likelihood of the first occurrence of ventricular tachycardia, ventricular fibrillation or death in this high-risk population.

29 Aug 2018

Researchers enlist genes that control production of cellular energy stored in ATP molecules

Everything the body does--your brain thinking, your heart beating, your cells growing--requires energy. Consequently, it comes as no surprise that disruptions in energy production can contribute to a wide range of diseases.

29 Aug 2018

FDA warns consumers and pet owners not to use drug products made by King Bio

The Food and Drug Administration is warning consumers and pet owners not to use drug products, including homeopathic drug products, made by King Bio Inc., Asheville, N.C., and labeled as Dr. King's, as these products may pose a safety risk to people (especially infants, children, pregnant women and those with compromised immune systems), as well as pets due to high levels of microbial contamination identified at the manufacturing site.

29 Aug 2018

New lung tissue-on-a-chip system offers rapid testing of potential anti-fibrotic treatments

Pulmonary fibrosis is one of the most common and serious types of lung disease. Now NIBIB-funded researchers have developed an in vitro lung tissue-on-a-chip system that mimics lung fibrosis, offering rapid testing of potential new anti-fibrotic treatments.

28 Aug 2018

Pediatric researchers discover gene mutation that causes lymphatic disorder

Pediatric researchers have identified a gene mutation that causes a serious lymphatic condition, and used that knowledge to restore normal lymphatic vessels in model animals. The laboratory findings may lead to a new therapy for patients with this type of abnormal lymphatic circulation.

28 Aug 2018

Researchers report how Zika proteins hijack host cells

Most people infected with Zika never show symptoms. But the virus sometimes causes severe disability -- from microcephaly in babies to weakness or partial paralysis in adults -- and there is no treatment.

28 Aug 2018

Delivering miRNAs to treat patients with inflammatory bowel disease

Inflammatory bowel disease, such as Crohn disease and ulcerative colitis, are chronic inflammatory diseases of unknown cause, and the number of IBD patients is on the rise.

28 Aug 2018

Non-invasive test could help avoid unnecessary heart procedures

Unnecessary heart procedures can be avoided with a non-invasive test, according to late breaking research presented at ESC Congress 2018 and published in Journal of the American College of Cardiology.

28 Aug 2018

Blood pressure lowering therapy and statins continue to improve survival in patients with hypertension

Blood pressure and cholesterol lowering drugs continue to improve survival in patients with hypertension after more than a decade, according to late breaking results from the ASCOT Legacy study presented at ESC Congress 2018 and published in The Lancet.

28 Aug 2018

Combined oral anticoagulant and antiplatelet therapy linked to poor prognosis in atrial fibrillation

Combined oral anticoagulant and antiplatelet therapy is associated with a worse prognosis than anticoagulation alone in newly diagnosed atrial fibrillation patients without a clear indication for antiplatelets, according to late breaking results from the GARFIELD-AF registry presented today at ESC Congress 2018.

28 Aug 2018

Drugs News and Research

Researchers receive $6 million NIH grant to improve treatment for Chagas disease

Hesperos receives SBIR grant to create ‘human-on-a-chip’ model to mimic Alzheimer's disease

Researchers uncover why some cancers grow faster than others

Researchers discover reason why many bladder cancer patients do not respond to immunotherapy

Research shows proteomics can be used to predict evolution of triple negative breast cancer

Researchers discover mechanism that steers growth of cancer cells in melanoma and liver cancer

Study suggests new strategies for using cell metabolism to treat cancer

Researchers develop better options to treat peripheral artery disease

New mathematical model helps understand transmission of drug-resistant malarial parasites

Researchers find how NF2 gene mutations lead to out-of-control cellular proliferation

Drug used for chest pain does not decrease chance of first occurrence of ventricular arrhythmias

Researchers enlist genes that control production of cellular energy stored in ATP molecules

FDA warns consumers and pet owners not to use drug products made by King Bio

New lung tissue-on-a-chip system offers rapid testing of potential anti-fibrotic treatments

Pediatric researchers discover gene mutation that causes lymphatic disorder

Researchers report how Zika proteins hijack host cells

Delivering miRNAs to treat patients with inflammatory bowel disease

Non-invasive test could help avoid unnecessary heart procedures

Blood pressure lowering therapy and statins continue to improve survival in patients with hypertension

Combined oral anticoagulant and antiplatelet therapy linked to poor prognosis in atrial fibrillation

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Bringing real-time analytics to downstream bioprocess monitoring

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Evaluating new approaches for rare disease genomics

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