Allopurinol News and Research

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Diabetes drug use linked to fewer gout treatments

Natalie McCormick, PhD, of the Rheumatology and Allergy Clinical Epidemiology Research (RACER) Center within the Division of Rheumatology in the Mass General Brigham Department of Medicine, is the lead author of a paper published in Diabetes Care, "Gout-Related Medication Use After Initiating Sodium–Glucose Cotransporter 2 Inhibitors in Patients With Gout and Type 2 Diabetes: Population-Based Target Trial Emulation Studies."

2 Feb 2026

Urate-lowering gout treatment can reduce the risk of heart attack and stroke

A groundbreaking new study, led by experts at the University of Nottingham, has found that medicines used to treat gout can also reduce the risk of heart attack and stroke in people with gout.

27 Jan 2026

New genetic marker may improve the ability to predict life-threatening reactions to gout medication

A newly identified genetic marker may significantly improve the ability to predict life-threatening reactions to the gout medication allopurinol in U.S. patients.

29 Oct 2025

New insights into gout management strategies and cardiovascular outcomes

The European Alliance of Associations for Rheumatology - recommends that serum urate should be maintained at <6 mg/dL (360 µmol/L) and <5 mg/dL (300 µmol/L) in those with severe gout.

15 Jun 2025

EMA designates allopurinol as first orphan drug for the treatment of Marfan syndrome

The European Medicines Agency (EMA) has designated allopurinol as the first orphan drug for the treatment of Marfan syndrome, a rare connective tissue disease which as no cure to date.

19 May 2025

Can the carnivore diet trigger kidney stones? Case study raises red flags

A case study in The American Journal of Clinical Nutrition examines how one patient’s switch to a carnivore diet increased kidney stone risk by raising calcium, uric acid, and oxalate levels while reducing protective citrate.

19 Feb 2025

Groundbreaking discovery offers hope for patients suffering from toxic epidermal necrolysis

A global team of researchers at the Max Planck Institute of Biochemistry has made a groundbreaking discovery that saves the lives of patients suffering from toxic epidermal necrolysis.

16 Oct 2024

Genetics identified as key factor in gout development

A major international study has found gout is a chronic illness where genetics is a major cause, rather than lifestyle choices of the sufferer.

15 Oct 2024

UCLA investigators receive $800,000 grant to treat and prevent aggressive kidney cancer

Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have received an $800,000 grant from the V Foundation to find new ways to treat and prevent a severe form of kidney cancer associated with a hereditary syndrome caused by mutations in the fumarate hydratase (FH) gene.

16 Jul 2024

Study: Spike in the price of gout drug colchicine linked to lower use and worse disease control

Due to a policy decision in 2010 by the U.S. Food and Drug Administration (FDA), the price of a prescription for the therapeutic gout drug colchicine increased nearly 16-fold from $11.25 in 2009 to $190.49 in 2011.

9 May 2023

The 2022 NICE guidelines for the diagnosis and management of gout

The 2022 National Institute for Health and Care Excellence (NICE) guidelines for the management of gout.

13 Mar 2023

Does treatment status relate to other diseases in gout patients?

A new study shows how urate-lowering therapy (ULT) is related to such conditions as chronic kidney disease (CKD) and cardiovascular disease (CVD).

8 Mar 2023

Effects of nanoparticles on gouty arthritis in animal models of gout

Researchers performed a systematic review and meta-analysis to explore the effects of nanoparticles on gouty arthritis using animal models.

23 Feb 2023

Mucoactive drugs block SARS-CoV-2 infection

Researchers evaluate the effects of mucociliary active molecules on SARS-CoV-2 infection in vitro.

7 Feb 2023

New method can control the growth of a substance known to cause kidney stones in dolphins

In the body, crystals – made of things such as calcium or a collection of urine – form masses that can cause pain and serious health conditions.

5 Feb 2023

Gout medicine fails to improve cardiovascular outcomes in patients with ischemic heart disease

The gout medicine allopurinol has failed to reduce the primary endpoint of nonfatal myocardial infarction, nonfatal stroke or cardiovascular death in patients with ischaemic heart disease, according to late breaking research presented in a Hot Line session today at ESC Congress 2022.

28 Aug 2022

Gout flares associated with subsequent cardiovascular events

Experts at the University of Nottingham, in collaboration with experts at Keele University, have found that the risk of heart attacks and strokes temporarily increases in the four months after a gout flare.

2 Aug 2022

Chronic kidney disease medication doesn’t work, shows study

A major clinical trial from the University of New South Wales (UNSW) reports that a medication called allopurinol, which is prescribed to about 20% of patients with chronic kidney disease (CKD), doesn’t work as expected. The results are published in the New England Journal of Medicine on June 25, 2020.

28 Jun 2020

Study shows generic drug does not slow kidney disease

Historically, half or more of people with type 1 diabetes develop kidney disease, which frequently progresses to kidney failure, requiring dialysis treatment or kidney transplantation for survival, according to a study in Diabetes Care.

26 Jun 2020

Promising treatment does not guard against complication in type 1 diabetes

Historically, half or more of people with type 1 diabetes develop kidney disease, which frequently progresses to kidney failure requiring hemodialysis or a kidney transplant for survival.

25 Jun 2020