BCG Vaccine News and Research

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The BCG Vaccine is a vaccine containing bacillus Calmette-Guerin (BCG), an attenuated strain of Mycobacterium bovis, with non-specific immunoadjuvant and immunotherapeutic activities. Although the mechanism of its anti-tumor activity is unclear, immunization with BCG vaccine likely activates a Th1 cytokine response that includes the induction of interferon. Vaccination with BCG vaccine may be immunoprotective against infection with Mycobacterium tuberculosis.

BCG vaccine may remodel the human brain's immune environment

New research led by Mass General Brigham investigators suggests that the Bacillus Calmette-Guérin (BCG) vaccine - which is delivered through the skin to prevent tuberculosis - may remodel the human brain's immune environment, offering a potential biological explanation for previously observed associations between BCG vaccination and lower Alzheimer's disease risk.

6 Jul 2026

MIT researchers identify new vaccine targets to fight tuberculosis

A large-scale screen of tuberculosis proteins has revealed several possible antigens that could be developed as a new vaccine for TB, the world's deadliest infectious disease.

5 Nov 2025

New insights into decades-old bladder cancer treatment offers clues for immunotherapy

More than three decades ago, the U.S. Food and Drug Administration (FDA) approved Bacillus Calmette-Guérin (BCG) as the first immunotherapy against cancer. And it is still used today to treat early-stage bladder cancer.

29 May 2025

BCG immunotherapy reprograms bone marrow to boost cancer defense

29 May 2025

Researchers create mycobacteria with kill switches to improve TB vaccine safety

Working toward more effective tuberculosis (TB) vaccines, researchers at Weill Cornell Medicine have developed two strains of mycobacteria with "kill switches" that can be triggered to stop the bacteria after they activate an immune response.

25 Feb 2025

Groundbreaking advances in tuberculosis vaccine development and therapies

Despite decades of efforts, tuberculosis remains a global health crisis, claiming over 1.3 million lives annually.

10 Feb 2025

Antibiotics, antivirals, vaccines and anti-inflammatory drugs associated with reduced dementia risk

Antibiotics, antivirals, vaccinations and anti-inflammatory medication are associated with reduced risk of dementia, according to new research that looked at health data from over 130 million individuals.

21 Jan 2025

Self-destructing vaccine offers safer TB protection in monkeys

A self-destructing vaccine administered intravenously provides additional safety and protection against tuberculosis (TB) in macaque monkeys, suggests new University of Pittsburgh research published today in Nature Microbiology.

10 Jan 2025

Deciphering the mechanisms of immune response with probabilistic graphical networks

Over the past two decades, new technologies have helped scientists generate a vast amount of biological data. Large-scale experiments in genomics, transcriptomics, proteomics, and cytometry can produce enormous quantities of data from a given cellular or multicellular system.

5 Nov 2024

Antibiotic resistance threatens millions of lives worldwide

More than 39 million people around the world could die from antibiotic-resistant infections over the next 25 years, according to a study published in The Lancet.

18 Sep 2024

Zebrafish model reveals how BCG vaccine triggers immune response in bladder cancer

Using zebrafish "Avatars", an animal model developed by the Cancer Development and Innate Immune Evasion lab at the Champalimaud Foundation (CF), led by Rita Fior, Mayra Martínez-López – a former PhD student at the lab now working at the Universidad de las Américas in Quito, Ecuador – and colleagues studied the initial steps of the Bacillus Calmette-Guérin (BCG) vaccine's action on bladder cancer cells.

8 Aug 2024

100-year-old BCG vaccine protects individuals with type 1 diabetes from infectious diseases

In new research, investigators at Massachusetts General Hospital (MGH) show that the 100-year-old Bacillus Calmette-Guérin (BCG) vaccine, originally developed to prevent tuberculosis, protects individuals with type 1 diabetes from severe COVID-19 disease and other infectious diseases.

22 May 2024

BCG Vaccine News and Research

BCG vaccine may remodel the human brain's immune environment

MIT researchers identify new vaccine targets to fight tuberculosis

New insights into decades-old bladder cancer treatment offers clues for immunotherapy

BCG immunotherapy reprograms bone marrow to boost cancer defense

Researchers create mycobacteria with kill switches to improve TB vaccine safety

Groundbreaking advances in tuberculosis vaccine development and therapies

Antibiotics, antivirals, vaccines and anti-inflammatory drugs associated with reduced dementia risk

Self-destructing vaccine offers safer TB protection in monkeys

Deciphering the mechanisms of immune response with probabilistic graphical networks

Antibiotic resistance threatens millions of lives worldwide

Zebrafish model reveals how BCG vaccine triggers immune response in bladder cancer

100-year-old BCG vaccine protects individuals with type 1 diabetes from infectious diseases

The path to a better tuberculosis vaccine runs through Montana

BCG vaccine's impact on innate immunity explained at cellular level

Towards a world free of tuberculosis: The ADVANCE-TB COST Action

Promising breakthroughs ignite hope for a novel and effective Tuberculosis vaccine

New TB vaccination strategy could save hundreds of thousands of lives with HIV

Results from a nested randomized controlled trial for BCG vaccination against recurrent herpes labialis

BCG vaccine associated with reduced risk of Alzheimer's disease and related dementias

Reducing COVID-19 burden: could Bacille Calmette-Guérin (BCG) vaccines confer protection?

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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