Cardiomyopathy News and Research

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Cardiomyopathy is a group of diseases with primary, usually diffuse, involvement of the myocardium. The myocardial disease is not secondary to ischaemic, valvular, congenital or pericardial disease.

AI learned from cardiologists’ notes, and needed far less labeled ECG data

By teaching an AI system to connect raw heart signals with the clinical insights contained in cardiologists’ reports, researchers tested whether routine ECGs could reveal more with far fewer labeled examples.

2 Sep 2026

Alcohol-related liver cancer deaths were falling. Then the trend reversed during the COVID-19 pandemic

A global analysis of GBD 2023 data found that alcohol-attributable liver cancer mortality increased modestly from 1990 to 2023, while mortality from alcohol-attributable cirrhosis, alcoholic cardiomyopathy, and alcohol use disorders declined. Liver cancer mortality shifted from a pre-pandemic decline to an increase during 2020–2023, particularly among women, although the researchers cautioned that the ecological analysis cannot establish that pandemic-related changes caused the reversal.

1 Sep 2026

ECG-CLIP improves heart disease detection using less labeled data

Clinicians often use a medical test called a 12-lead electrocardiogram (ECG) to diagnose heart problems, which uses electrodes placed on the chest and limbs to record the heart's electrical activity.

1 Sep 2026

Aficamten improves symptom burden and exercise capacity in patients with non-obstructive HCM

Aficamten treatment was associated with significant improvements in symptom burden and exercise capacity in patients with symptomatic non-obstructive hypertrophic cardiomyopathy, according to results presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in the New England Journal of Medicine.

28 Aug 2026

Younger heart patients benefit from implantable cardioverter-defibrillators in CMR GUIDE trial

An implantable cardioverter-defibrillator did not improve the primary endpoint overall in the CMR GUIDE trial but younger patients appeared to benefit, according to results presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in JAMA.

28 Aug 2026

CARDIO-TTRansform trial investigating eplontersen fails to meet primary efficacy endpoint

The CARDIO-TTRansform trial investigating eplontersen in patients with transthyretin-mediated amyloid cardiomyopathy did not meet its primary efficacy endpoint, according to results presented in a Hot Line session today at ESC Congress 2026.

28 Aug 2026

Review explores complex links between obesity and cardiovascular diseases

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Obesity, given its strong association with cardiovascular diseases (CVDs), is a major global public health issue attracting increasing attention.

27 Aug 2026

New AI spots hypertrophic cardiomyopathy obstruction from standard ultrasounds

Mayo Clinic researchers have developed and externally validated an artificial intelligence (AI) model that can identify a potentially significant heart obstruction from routine ultrasound videos without relying on specialized Doppler imaging.

19 Aug 2026

Intertwined cellular processes reshape understanding of diabetes

A deeper understanding of how key cellular processes interact is reshaping perspectives on diabetes and its wide-ranging complications.

5 Aug 2026

Genetic variants interact to increase early-onset atrial fibrillation risk

An estimated 10 million Americans have atrial fibrillation (AFib), according to the National Institutes of Health's National Heart, Lung, and Blood Institute.

31 Jul 2026

Scientists uncover how muscle actin filaments grow and renew themselves

Biophysicists unraveled a mystery of how muscles form at the molecular level and how they maintain their function.

29 Jul 2026

Small changes in one heart protein cause distinct cardiomyopathies

Cardiomyopathies are a group of mostly hereditary, rare heart diseases in which the structure of the heart muscle tissue is impaired.

29 Jul 2026

Daily multivitamin improves functional health in older adults, study finds

The ability to perform everyday activities free of debilitating symptoms profoundly affects quality of life as we age.

27 Jul 2026

Scientists link genetic spelling mistakes to sudden cardiac death

Scientists have found that the 'sudden' cardiac death condition related to high profile deaths or major medical episodes of sports stars including Fabrice Muamba, Christian Erikson and Mark-Vivian Foe has numerous linked gene variations, or "spelling mistakes", which highlights a potentially treatable vulnerability.

21 Jul 2026

NOX4 inhibition may protect hearts affected by Duchenne muscular dystrophy

Researchers at the University of South Florida USF Health Morsani College of Medicine have identified a potential pathway that could protect cardiac function in people with Duchenne muscular dystrophy, a progressive and fatal genetic disease that weakens the body's muscles.

17 Jul 2026

New molecular mechanism identified in common inherited heart disease

A study led by the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), working in collaboration with an international research team, has identified a new molecular mechanism involved in hypertrophic cardiomyopathy, the most common inherited cardiovascular disease.

7 Jul 2026

Vascular organoids may be an effective treatment for ischemic heart disease

Ischemic heart disease (IHD), also known as coronary artery disease, is a leading cause of death and morbidity in western countries. IHD arises when blood vessels of the heart become clogged, blunting oxygen and nutrient supply to heart muscle cells, which eventually die off, leading to heart attack or heart failure.

2 Jul 2026

Review links iron-dependent cell death to pathogenesis of Friedreich's Ataxia

Published in the open-access journal Ferroptosis and Oxidative Stress, the review by Giovanni Cravin and Giorgio Cozza from the University of Padua examines the growing evidence linking ferroptosis to the pathogenesis of Friedreich's Ataxia (FRDA), a rare inherited neurodegenerative disease characterized by progressive neurological decline, cardiomyopathy, and premature mortality.

30 Jun 2026

Three courageous heart transplant survivors are celebrated by the British Heart Foundation for giving their old hearts for research

The British Heart Foundation is celebrating three incredible young women who donated their old hearts to science after having heart transplant surgery.

25 Jun 2026

Recognizing perinatal heart failure early reduces life-threatening risks

Early detection and timely treatment of heart failure in pregnant or postpartum women are crucial to prevent serious complications, such as irregular heartbeat, stroke and death, according to a new American Heart Association scientific statement, "Heart Failure Occurring in the Perinatal Period."

25 Jun 2026