Craniofacial News and Research

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Natural tooth protein could pave way for regenerative dental treatments

A protein that helps build teeth may one day be used to allow damaged teeth to repair themselves.

2 Nov 2026

Spatial study maps active epithelial crosstalk driving chronic periodontitis

Epithelial barriers are active organizers of tissue homeostasis, immune surveillance and host defense, yet chronic inflammation can corrupt their repair and communication with connective tissue.

2 Nov 2026

Mechanical force triggers metabolic changes that promote orthodontic bone formation

Bone adapts to mechanical force through coupled formation and resorption, a principle central to orthodontics.

30 Oct 2026

Researchers uncover molecular pathway controlling bone resorption and tooth eruption

RUNX2 is best known as a master transcription factor of osteoblast differentiation. Mutations in, or haploinsufficiency of RUNX2 cause CCD, a skeletal disorder characterized by delayed permanent tooth eruption, supernumerary teeth and clavicular defects.

30 Oct 2026

Understanding the mechanisms of multilineage coordination during craniofacial development

The human face is one of the most complex structures formed during embryonic development. Its formation requires different cell populations to produce bones, muscles, nerves, blood vessels, teeth, and glands, all arranged in the correct positions and connected to perform their functions.

29 Oct 2026

Study identifies Piezo channels as targets for orthodontic care

A new review in Genes & Diseases highlights Piezo channels as important biological links between mechanical forces and the cellular processes that shape the face, move teeth and influence oral health.

12 Oct 2026

Loss of tumor suppressor p53 reshapes Wnt signaling to drive mutant cell expansion

A protein known as p53 is, of all tumor suppressors in human cancer, the most frequently altered by gene mutations.

1 Oct 2026

NIH funds national center to advance root canal alternatives

Which would you rather have: a root canal or a pulpotomy? Even if you're not familiar with a pulpotomy, you might be inclined to learn more.

23 Sep 2026

Scientists discover tiny protein region that shapes tooth enamel

Tooth enamel looks simple from the outside and consists of a hard, smooth surface built to withstand years of wear.

11 Sep 2026

Researchers uncover molecular pathway driving craniosynostosis

Craniosynostosis is a congenital developmental disorder in which the skull's cranial sutures fuse prematurely.

28 Aug 2026

Penn State team lays groundwork to 3D print spheroids for regenerating bone tissue

An interdisciplinary team of engineers and chemists at Penn State has laid the groundwork to 3D print spheroids - tiny clusters of living cells - capable of regenerating bone tissue in response to severe trauma or infections.

18 Aug 2026

Discovery may help develop new treatments for immunosuppressed skin cancer patients

Researchers at The University of Texas MD Anderson Cancer Center have discovered that immunosuppressed patients with non-melanoma skin cancer are not missing the key cancer-fighting immune cells found in immunocompetent patients, but those cells – known as macrophages – have lost the ability to communicate effectively.

5 Aug 2026

Myotonia may play a much larger role in driving muscle damage than previously recognized

For decades, researchers studying myotonic dystrophy type 1 (DM1) have focused on the disease's underlying genetic cause: a mutation that produces a toxic form of RNA, disrupting the normal processing of thousands of genetic messages inside cells.

13 Jul 2026

Advanced 3D imaging reveals hidden nerve networks inside joints

Temporomandibular disorders (TMDs) are a group of more than 30 conditions that cause pain and dysfunction in the jaw.

7 Jul 2026

Engineered scaffold restores skull growth in craniosynostosis mouse models

An engineered triphasic biomaterial scaffold successfully recreated the cranial suture stem cell niche lost in craniosynostosis, a condition that causes premature fusion of skull bones.

5 Jul 2026

Opioid prescribing after pediatric surgery varies widely across hospitals

Whether children receive an opioid prescription after surgery varies substantially by procedure type and hospital, according to a new national analysis published in the Journal of the American College of Surgeons (JACS).

1 Jul 2026

Genetic research links KDF1 mutation to impaired dental epithelial organization

Dental enamel is the hardest substance in the human body, protecting teeth from wear, temperature changes, and decay. However, enamel cannot regenerate once damaged. Inherited disorders, such as amelogenesis imperfecta, disrupt enamel formation during development, leaving affected individuals with fragile, discolored, and decay-prone teeth.

30 Jun 2026