DNA Damage News and Research

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Chronic DNA damage response may contribute to biological aging

A new review was published in Volume 18 of Aging on August 31, 2026, titled "The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework."

21 Sep 2026

Cohesin protein protects genetic information during cell division

Cell division, a process fundamental to life, still holds surprises. Researchers from the University of Zurich and the Spanish National Cancer Research Centre (CNIO) have discovered a key mechanism that allows cells to protect genetic information as they divide.

21 Sep 2026

MIT researchers develop noninvasive way to spot aging zombie cells

As we age, some of the cells in our body enter a state of senescence, in which they stop dividing but do not die. Those senescent cells can contribute to age-related disorders such as cancer, tissue degeneration, and inflammatory diseases.

21 Sep 2026

German researchers aim to completely degrade breast cancer protein

Simply switching off a protein that helps breast cancer cells to grow? That is not enough for researchers at the University of Duisburg-Essen.

21 Sep 2026

Biological mechanisms validate structured exercise as therapeutic in oncology care

Structured exercise may help people with cancer live longer and have more time free of disease, finds a synthesis of the available evidence, published online in the British Journal of Sports Medicine.

16 Sep 2026

Why frailty and heart health may be more closely connected than we thought

A narrative review proposes cardiovascular frailty as a distinct phenotype that brings together blood pressure regulation, vascular aging, oxi-inflammaging, and clinical frailty deficits. The authors argue that a validated cardiovascular frailty index could support earlier detection and personalized care, although longitudinal studies are needed before the concept can be used clinically.

15 Sep 2026

Childhood chemotherapy leaves lasting DNA damage in healthy cells

Chemotherapy, which saves the lives of many children with cancer, causes previously unknown DNA alterations in the liver and leaves genetic footprints in other healthy cells as well.

10 Sep 2026

Study reveals hidden DNA damage from childhood chemotherapy

The amount of DNA damage caused by certain chemotherapies used to effectively treat childhood cancer has been revealed, along with a hidden impact on the liver, paving the way for future research into new ways to mitigate these impacts.

10 Sep 2026

Study reveals processes driving DNA damage in prostate cancer

Cancer begins with errors in the DNA inside our cells, and those errors are often more complicated than a handful of mutated genes.

9 Sep 2026

New base editing techniques accurately modify genes in human embryos

A study by researchers at Columbia University Vagelos College of Physicians and Surgeons has found that new cutting-edge techniques can accurately edit genes in human embryos-giving scientists indispensable tools for understanding normal human development-but has also uncovered important risks that currently preclude the use of the techniques in the clinic.

9 Sep 2026

Caloric restriction reduces genetic mutations across the mouse genome

Mutations are changes in the molecular "letters" that make up DNA, the genetic blueprint for cells. Mutations build up with age in every cell when DNA is damaged or when cells make mistakes in fixing or copying it.

9 Sep 2026

Researchers use an experimental drug to reverse the effects of systemic sclerosis

Investigators at Cedars-Sinai Health Sciences University used an experimental drug to reverse the effects of systemic sclerosis, a serious autoimmune disease. The study, conducted in a laboratory, was published in JCI Insight.

8 Sep 2026

Cancer-fighting T cells need small amounts of ROS to attack tumors, study finds

New research reveals a promising new target for treating cancer by harnessing a type of molecule previously thought to do more harm than good.

3 Sep 2026

High-dose folic acid appears safe from formaldehyde toxicity

Folic acid – an essential vitamin added to flour and cereals and prescribed at high doses for cancer patients and people with blood disorders – does not elevate toxic formaldehyde in the body, according to a new Cornell University study on mice and human cancer patients who consumed high doses.

2 Sep 2026

New research could improve how brain cancer and tumors are treated

Australian researchers are challenging decades-old assumptions about brain cancer treatment in a bid to make radiation therapy more effective against tumors, while reducing damage to healthy tissue.

29 Aug 2026

Cell proliferation gene plays a distinct role in cells that no longer proliferate

In a tale of identities as divergent as "The Prince and the Pauper," a well-known cancer-causing gene also influences cells in a zombie-like state meant to prevent cancer.

28 Aug 2026

New research questions decades-old assumptions about brain cancer treatment

Australian researchers are challenging decades-old assumptions about brain cancer treatment in a bid to make radiation therapy more effective against tumors, while reducing damage to healthy tissue.

28 Aug 2026

New funding backs pioneering research to make brain cancer treatment more effective

Adelaide researchers are challenging decades-old assumptions about brain cancer treatment in a bid to make radiation therapy more effective against tumors, while reducing damage to healthy tissue.

27 Aug 2026

Scientists identify new drug target to combat airborne tuberculosis

Tuberculosis bacteria released into the air from infected individuals dry out to form infectious particles that are second only to measles in contagiousness.

26 Aug 2026

Scientists uncover safer way to tame cancer cell senescence

Stopping tumor growth is only half the battle. Rather than kill tumor cells, many cancer therapies can only push them into cellular senescence, a state in which cells stop dividing but do not die. These "undead" cells will continue to release signals that reshape the tumor environment.

20 Aug 2026