DNA Damage News and Research

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IITGN research explores new approach to tackling drug-resistant glioblastoma

Cancer remains among the most deadly diseases worldwide. Globally, more than 300,000 new cases of brain cancer are reported each year, with glioblastoma, an aggressive form of brain cancer, accounting for over 250,000 deaths.

6 Nov 2026

Developing brains may have a way to remove genetically abnormal neurons

A significant reduction in genetic abnormalities in cortical neurons occurs after birth, suggesting a selective elimination mechanism in brain development.

6 Nov 2026

Vulnerable DNA sites make cancer cells sensitive to PARP inhibitors

A small subset of vulnerable DNA sites can make cancer cells highly sensitive to targeted drugs called PARP inhibitors, a new study shows.

5 Nov 2026

Plant metabolite shows strong promise as a natural human sunscreen

Research in Photochemistry and Photobiology indicates that a plant metabolite that can block the effects of ultraviolet (UV) light has promising potential as a natural sunscreen when applied to human skin.

4 Nov 2026

Hyperactive cancer-promoting proteins help tumor cells evade immune attack

The immune system may recognize a cancer cell and still fail to destroy it. Researchers at Hiroshima University and their international collaborators found that hyperactive YAP and TAZ (YAP/TAZ), two cancer-promoting proteins, were associated with genomic instability that may make cancer cells more recognizable to the immune system, while also increasing PD-L2, which helps the cells suppress T-cell attack.

30 Oct 2026

New microscopy platform enables deeper brain imaging without tissue damage

As light travels deeper into the brain, it scatters. Three-photon microscopy, the current state of the art, reduces the resulting background fluorescence and can, in principle, image much deeper than earlier techniques-but to do that, it uses average laser power limits that cause overheating and damage living tissue.

28 Oct 2026

Heated tobacco products cause immediate cardiovascular and genetic damage

Just one session of heated tobacco product use results in measurable damage to the blood vessels, according to a study published today (Tuesday) in the European Journal of Preventive Cardiology.

27 Oct 2026

Study reveals how cancer cells survive chemotherapy in a zombie-like state

Scientists at Trinity College Dublin have made an important breakthrough in understanding how cancer cells can evade the cell-killing effects of chemotherapy and enter a "zombie-like state", called premature senescence, that can attract the wound healing properties of the immune system.

23 Oct 2026

PARP1 remodels nucleosomes to help cells repair damaged DNA

When DNA is damaged, cellular processes respond and repair the DNA. Inhibiting DNA damage repair can be therapeutically beneficial in cancers with genetic vulnerabilities related to DNA damage response.

23 Oct 2026

Study identifies potential new ways to treat the most common type of bowel cancer

Major new research published today identifies potential new ways to treat the most common type of bowel cancer in Ireland.

23 Oct 2026

Stem cell therapies may need new protein quality control standards

Current Good Manufacturing Practice (GMP) standards for cell therapies assess identity, viability, sterility, and genetic stability. For extracellular vesicle (EV) products, Minimal Information for Studies of Extracellular Vesicles (MISEV2023) guidance adds particle size, concentration, markers, morphology, contaminants, endotoxin, and assays.

22 Oct 2026

Cell Painting method reveals drug differences in 3D cancer cells

Researchers at Uppsala University have adapted Cell Painting, a widely used imaging method in drug discovery, to look at individual cells inside small 3D clusters of cancer cells.

21 Oct 2026

Local DNA motion remains nearly constant during cell interphase

Human genomic DNA is wrapped around core histone proteins to form nucleosomes, the fundamental units of chromatin.

14 Oct 2026

Scientists identify novel autoimmune driver behind DNA repair breakdown in childhood cancer

Researchers have found the first evidence for a previously unsuspected cause of pediatric cancer. They showed that children with such cancers were more likely than their healthy peers to produce ‘auto-antibodies’ targeting six proteins necessary for normal DNA repair. Likewise, they showed that young adults with cancer had greater amounts of these circulating antibodies already years before diagnosis.

14 Oct 2026

New research shows reduced toxicant exposure reduces biological activity

Two newly published studies from Imperial Brands scientists have provided further evidence that products associated with lower levels of combustion-related toxicants also produce substantially lower levels of combustion-related toxicants also produce substantially lower biological activity than cigarette smoke under laboratory conditions.

13 Oct 2026

Mini-GRID radiotherapy limits cellular senescence in glioma models

A new research paper was recently published in Volume 18 of Aging, titled "Spatially fractionated mini-GRID radiotherapy differentially modulates radiation-induced senescence in murine glioma and normal cells."

6 Oct 2026

Varying mutation rates in healthy organs explain cancer risk

A new study by scientists at City of Hope® and TGen, part of City of Hope, found surprisingly large differences in the number of mutations present in organs of healthy individuals.

1 Oct 2026

USP15 enzyme emerges as potential target for ovarian cancer treatment

Ovarian cancer is often diagnosed after it has already spread to other parts of the body, at which point the five-year survival rate is under 30 percent.

24 Sep 2026

Chronic DNA damage response may contribute to biological aging

A new review was published in Volume 18 of Aging on August 31, 2026, titled "The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework."

21 Sep 2026

Cohesin protein protects genetic information during cell division

Cell division, a process fundamental to life, still holds surprises. Researchers from the University of Zurich and the Spanish National Cancer Research Centre (CNIO) have discovered a key mechanism that allows cells to protect genetic information as they divide.

21 Sep 2026