Duloxetine News and Research

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Duloxetine is approved in the United States for the acute and maintenance treatment of major depressive disorder, the acute treatment of generalized anxiety disorder, and the management of diabetic peripheral neuropathic pain and fibromyalgia in adults aged 18 years and older. Duloxetine is not approved for use in pediatric patients.

Study finds some sweeteners can slow the growth of gut bacteria

Cambridge researchers have shown how commonly-used sweeteners slow the growth of certain gut bacteria.

16 Jul 2026

Duloxetine fails to prevent nerve damage caused by chemotherapy

A randomized trial conducted by the Alliance for Clinical Trials in Oncology with support from the National Cancer Institute has found that duloxetine, a medication commonly used to treat chronic pain and psychiatric conditions, does not prevent nerve damage caused by chemotherapy in patients with colorectal cancer.

8 Apr 2026

Pregabalin raises heart failure risk in older adults compared to gabapentin, study finds

A large Medicare cohort study found that older adults prescribed pregabalin had a significantly higher risk of developing heart failure compared to those prescribed gabapentin. The elevated risk was most pronounced in individuals with pre-existing cardiovascular disease, especially women and White patients.

13 Aug 2025

New analysis shows stopping antidepressants rarely leads to severe symptoms

The largest review of 'gold standard' antidepressant withdrawal studies to date has identified the type and incidence of symptoms experienced by people discontinuing antidepressants, finding most people do not experience severe withdrawal.

10 Jul 2025

Study highlights limited evidence for antidepressants in treating pain in older adults

University of Sydney research has found people over 65 are being prescribed antidepressants as pain treatment based on international guidelines that use limited evidence.

16 Sep 2024

New option emerges for managing stress urinary incontinence

An investigational medication designated TAS-303 shows efficacy and safety in treatment of women with stress urinary incontinence (SUI), reports a placebo-controlled clinical trial in the August issue of The Journal of Urology®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.

12 Jul 2024

New AI tool analyzes medical history to match patients with best antidepressant

Researchers in George Mason University's College of Public Health have leveraged the power of artificial intelligence (AI) analytical models to match a patient's medical history to the most effective antidepressant, allowing patients to find symptom relief sooner.

30 May 2024

New drug shows promise for treating chronic neuropathic pain

A non-opioid designer molecule for treating chronic neuropathic pain by calming hyperactive pain-sensing neurons in the peripheral nervous system has had promising results in a preclinical study conducted by researchers at Weill Cornell Medicine and the Burke Neurological Institute.

2 Aug 2023

Some antidepressants may be effective in treating chronic pain, but others lack effectiveness

New research has found some antidepressants may be effective in treating certain chronic pain conditions, but others lack convincing evidence on their effectiveness.

1 Feb 2023

Commonly prescribed antidepressants can increase bacteria's resistance to antibiotics

University of Queensland researchers have found a range of commonly prescribed antidepressants can increase bacteria's resistance to antibiotic medications.

1 Feb 2023

Researchers assess the evidence basis for medications used to treat spine-related pain in older adults

Spine-related pain is increasingly common in older adults. While medications play an important role in pain management, their use has limitations in geriatric patients due to reduced liver and kidney function, comorbid medical problems and polypharmacy (the simultaneous use of multiple drugs to treat medical conditions).

28 Jun 2022

Study examines if antidepressants can benefit patients with osteoarthritis

A clinical trial published in Arthritis & Rheumatology recently examined whether duloxetine, a medication that is prescribed to treat depression and may also reduce chronic pain, can benefit patients with hip or knee osteoarthritis.

6 Jan 2022

AAN issues new guideline on oral and topical treatments for painful diabetic neuropathy

Diabetic neuropathy refers to nerve damage due to diabetes and it may lead to pain and numbness, most often in the hands and feet. To help neurologists and other doctors determine the best treatment for people with diabetic neuropathy, the American Academy of Neurology (AAN) has issued a guideline on oral and topical treatments for painful diabetic neuropathy.

28 Dec 2021

Drug accumulation alters gut bacterial metabolism and composition

In a research paper recently published in the journal Nature by Klünemann et al. (September 8th, 2021), the interaction of 15 diverse drugs with 25 common strains of gut bacteria is investigated, revealing 70 bacteria-drug interactions that include 29 entirely novel mechanisms not yet reported.

15 Sep 2021

Duloxetine News and Research

Study finds some sweeteners can slow the growth of gut bacteria

Duloxetine fails to prevent nerve damage caused by chemotherapy

Pregabalin raises heart failure risk in older adults compared to gabapentin, study finds

New analysis shows stopping antidepressants rarely leads to severe symptoms

Study highlights limited evidence for antidepressants in treating pain in older adults

New option emerges for managing stress urinary incontinence

New AI tool analyzes medical history to match patients with best antidepressant

New drug shows promise for treating chronic neuropathic pain

Some antidepressants may be effective in treating chronic pain, but others lack effectiveness

Commonly prescribed antidepressants can increase bacteria's resistance to antibiotics

Researchers assess the evidence basis for medications used to treat spine-related pain in older adults

Study examines if antidepressants can benefit patients with osteoarthritis

AAN issues new guideline on oral and topical treatments for painful diabetic neuropathy

Drug accumulation alters gut bacterial metabolism and composition

Study finds accumulation of common therapeutic drugs by gut bacteria

Study: Duloxetine may reduce cumulative opioid use after total knee arthroplasty

Antidepressants provide no important benefits for managing low back pain

Study reveals potential risk factors for developing nerve damage after cancer treatment

Enriched diet and companionship can reduce pain in mice with sickle cell disease

Researchers reveal new mechanism of pain control

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