Endonuclease News and Research

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$Study identifies Apex1 as a redox-regulated driver of fracture repair$

Study identifies Apex1 as a redox-regulated driver of fracture repair

Bone fractures usually heal efficiently, but in some patients this process fails, causing nonunion. A recent study identifies Apex1 as a redox-regulated driver of fracture repair.

2 Feb 2026

Baloxavir reduces flu-related hospitalizations more than oseltamivir

A study reveals baloxavir outperforms oseltamivir in reducing hospitalization rates for influenza, highlighting its clinical advantages in outpatient settings.

17 Dec 2025

New type of mitochondrial DNA damage revealed

A previously unknown type of DNA damage in the mitochondria, the tiny power plants inside our cells, could shed light on how our bodies sense and respond to stress.

20 Nov 2025

Tokyo researchers reveal key role of Fen1 in resisting antiviral and anticancer drug effects

Researchers from Tokyo Metropolitan University have discovered a new pathway by which cells counteract the action of alovudine, an important antiviral and anticancer drug.

10 Aug 2025

ADC189 shows promise as a single-dose treatment for influenza

Influenza continues to pose a significant global health burden, with seasonal outbreaks causing substantial morbidity and mortality.

24 Jun 2025

Yeast cells offer promising alternative for manufacturing DNase1

The protein DNase1 is one of the oldest biological agents in history: It has been on the market since 1958 and is now used, among other things, to treat cystic fibrosis.

28 May 2025

New enzyme family enables targeted cuts in single-stranded DNA

An INRS team discovers a new family of enzymes capable of inducing targeted cuts in single-stranded DNA .

16 Apr 2025

Genetic factors that make the bacteria behind cholera so dangerous uncovered

Study reveals key genetic factors in Vibrio cholerae O1 that drive cholera transmission and severity, highlighting targets for novel therapeutic strategies.

26 Sep 2024

Phages use selfish DNA to outmaneuver competitors

Curious bits of DNA tucked inside genomes across all kingdoms of life historically have been disregarded since they don't seem to have a role to play in the competition for survival.

5 Jul 2024

Research reveals how Regnase-1 deficiency enhances NK cell tumor killing

Natural killer (NK) cells play a crucial role in the first line of host defense by eliminating bacteria, viruses, and mutated cells that might become cancer cells.

30 May 2024

Rapid miRNA detection with one-pot isothermal rolling circle amplification

This study is led by Professor Jue Ruan (Chinese Academy of Agricultural Sciences, Shenzhen, China). The authors developed a one-pot isothermal detection method based on rolling circle amplification (RCA) for rapid and specific detection of miRNAs and short RNA fragments.

29 Mar 2024

Breakthrough gene silencing method slashes cholesterol for a year in mice, no DNA damage

Researchers developed an engineered transcriptional repressor that durably silences the Pcsk9 gene in mice, reducing cholesterol levels for up to a year with a single treatment, showcasing a potential breakthrough in genetic disorder treatments without the risks of DNA mutation.

29 Feb 2024

Innovative Subak tool offers affordable solution for detecting nuclease digestion

A new tool could reduce costs for diagnosing infectious diseases.

27 Feb 2024

Researchers identify a new approach to controlling bacterial infections

Researchers at the Icahn School of Medicine at Mount Sinai have identified a new approach to controlling bacterial infections.

7 Feb 2024

Researchers identify a rare cause of male infertility and discover a potential cure

Researchers investigated the genetic underpinning of asthenozoospermia, the leading cause of male fertility.

18 Sep 2023

Study examines health impacts of second-hand cigarette smoke exposure

In a recent study, researchers evaluated the effects of chronic second-hand smoke exposure on cognition, behavior, neuropathology, and metabolism.

29 Aug 2023

Cryo-EM reveals structure of key enzyme involved in protein production

Transfer RNAs (tRNAs) are among the most common types of RNA in a cell and are indispensable for protein production in all known organisms.

13 Jul 2023

How New Genomic Techniques can make agricultural production more sustainable

The EU Commission announced the release of a draft proposal for a reformed regulation of New Genomic Techniques (NGTs) that is expected to be published in early July 2023.

29 Jun 2023

First programmable RNA-guided system found in eukaryotes

A team of researchers led by Feng Zhang at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT has uncovered the first programmable RNA-guided system in eukaryotes - organisms that include fungi, plants, and animals.

28 Jun 2023

North American arrival of A(H5N1) influenza raises concerns of potential pandemic outbreak

Rapid global expansion of highly pathogenic avian influenza A(H5N1) viruses in 2021, including reassortment with North American strains, highlights the need for proactive measures to combat their spread and mitigate the risk of a potential pandemic originating from these reassortants.

31 May 2023