Fibroblast News and Research

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Fibroblasts are connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

Mechanical force triggers metabolic changes that promote orthodontic bone formation

Bone adapts to mechanical force through coupled formation and resorption, a principle central to orthodontics.

30 Oct 2026

Researchers discover how faulty matrix structure leads to cell death in newly formed bone

Bone cells called osteocytes help maintain skeletal strength, but how newly formed osteocytes survive remains unclear.

26 Oct 2026

Women with low bone density reported less pain after taking pine bark extract

A randomized clinical trial involving 67 women with osteopenia or stable osteoporosis found that three months of Pycnogenol® supplementation improved self-reported bodily pain and vitality scores compared with placebo. However, overall disease-specific quality of life did not significantly improve, and the six-month findings were insufficient to establish long-term benefits or safety.

15 Oct 2026

Novel gene rejuvenation therapy preserves cell identity while reversing age

Every organ and tissue progressively loses function and integrity as it ages. In fact, researchers have identified "hallmarks of aging" that not only present specific processes impacted by age, but are also thought of as levers that, if successfully targeted, could help turn back the aging clock and result in tissue rejuvenation.

14 Oct 2026

Targeting the RUNX1 gene helps reduce severe skin fibrosis

Skin fibrosis includes hypertrophic scar (HTS), keloid scar (KS), and systemic sclerosis (SSc). These conditions share persistent fibroblast activation, excessive extracellular matrix (ECM) deposition, and progressive skin remodeling.

13 Oct 2026

Many herbal toothpastes fell short on a key cavity-fighting ingredient

A study on herbal toothpastes reveals varying fluoride levels, antibacterial efficacy, and cytotoxicity, highlighting safety concerns in oral hygiene products.

5 Oct 2026

Spatial mapping reveals macrophage niches linked to severe COVID-19 lung injury

Researchers at the University of Liège have used imaging-based spatial single-cell transcriptomics to map the cellular organization of lungs from people who died with severe COVID-19.

1 Oct 2026

From espresso to filter coffee, brewing may shape what reaches your gut

A focused narrative review traces how caffeine, chlorogenic acids, and coffee fibers move through the gut and interact with microbes. The authors identify plausible links between the microbiome and liver health, but human studies have not shown that microbiome changes cause coffee’s reported metabolic benefits.

28 Sep 2026

Researchers find how prostate tumors reshape the immune microenvironment

Researchers at The University of Texas MD Anderson Cancer Center have identified a previously unknown pathway that prostate tumors leverage to suppress the immune system by reshaping the tumor microenvironment to resist treatment.

25 Sep 2026

Study identifies shared pathway driving cardiac fibrosis

Three adenosine receptor subtypes that normally send different signals were found to converge on a common pathway that activates cardiac fibroblasts, the scar-forming cells in the heart.

24 Sep 2026

Elusive stem cells offer clues to treat lumbar spinal stenosis

Researchers at Weill Cornell Medicine and Hospital for Special Surgery have discovered the stem cells—unspecialized cells that can develop into specific cell types—that give rise to the body's tendons and ligaments, the tissues connecting muscles and bones.

7 Sep 2026

Misfolded proteins slip past cell cleanups and risk causing disease

As proteins are made in a cell, they are folded into the 3-D structure that allows them to work, but sometimes this process can go wrong.

4 Sep 2026

Researchers uncover molecular pathway driving craniosynostosis

Craniosynostosis is a congenital developmental disorder in which the skull's cranial sutures fuse prematurely.

28 Aug 2026

New injectable microgel system delivers precise radiation to keloids

Researchers in Korea are developing a new approach to localized brachytherapy that could improve the treatment of keloid scars.

27 Aug 2026

Glioma microenvironment emerges as key target for future therapies

The prognosis for glioma patients remains extremely poor despite aggressive multimodal standard therapy: maximal safe resection, radiotherapy, and temozolomide chemotherapy, with median survival rarely exceeding 15 to 18 months.

20 Aug 2026

Basel researchers challenge decades of belief about coronin proteins

Scientific progress comes not only from discovering something entirely new, but also from taking a fresh look at long-held assumptions.

18 Aug 2026

Restricting select amino acids may mimic protein restriction’s healthy aging benefits

A review finds that restricting protein, particularly methionine, isoleucine, and valine, may improve metabolism and influence key aging pathways, largely in experimental models. Short human studies suggest metabolic benefits, but effects on lifespan remain unknown and restriction may harm people with unmet or increased protein needs.

3 Aug 2026

Consuming less protein could have greater health benefits and extend lifespan

Protein-fortified foods are popping up everywhere, from cereal and coffee to even protein water. But a new review covering over 350 papers on protein restriction and aging-publishing July 31 in the Cell Press journal Cell Press Blue-suggests that consuming less protein could have greater health benefits and could, in some cases, extend lifespan.

31 Jul 2026

Researchers identify key barrier preventing self repair of heart cells

Specialized cells in our body make biological tradeoffs to do certain jobs. To support large and hardworking hearts that power our other organs, our heart cells evolved to be extremely efficient and resilient.

28 Jul 2026

This edible flower could do more than brighten a plate

A review of 76 publications finds that pot marigold contains more than 500 reported secondary metabolites, along with natural pigments, antioxidants, and substantial dietary fiber. Early food studies report promising results in yogurt, bread, pasta, and edible oils, but limited product trials and no clinical evidence currently prevent human health claims.

28 Jul 2026