Induced Pluripotent Stem Cells News and Research

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Spaceflight research opens new avenues for studying rare pediatric diseases

Earth-based hiPSC models have transformed disease research but remain limited by cellular immaturity, a strong reliance on glycolysis rather than oxidative phosphorylation (OXPHOS), and incomplete tissue architecture.

3 Nov 2026

Study uncovers a protective role for microglia in Parkinson's disease

Researchers at the University of Oxford have uncovered a previously unrecognized protective role for microglia, the brain's resident immune cells, in Parkinson's disease.

7 Oct 2026

Study identifies shared pathway driving cardiac fibrosis

Three adenosine receptor subtypes that normally send different signals were found to converge on a common pathway that activates cardiac fibroblasts, the scar-forming cells in the heart.

24 Sep 2026

Mount Sinai researchers discover how Alzheimer's gene damages blood vessels

Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer's disease, damages the brain's blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease.

24 Sep 2026

Active form of meprin-β protein increases in people with Alzheimer’s disease

A team from the Altered Molecular Mechanism in Alzheimer's Disease and Dementia laboratory, led by Javier Sáez Valero, a researcher at the Institute for Neurosciences (IN), a joint centre of the Miguel Hernández University of Elche (UMH) and the Spanish National Research Council (CSIC), has identified increased levels of the protein meprin-β in the brain and cerebrospinal fluid of people with Alzheimer's disease.

21 Sep 2026

Norwegian scientists harvest super donor cells to fight diverse diseases

Cells from nine "super donors" are being collected in Oslo. The aim is for these to be used to repair or replace damaged cells, tissue and organs in people suffering from conditions ranging from heart attacks to Parkinson's disease.

16 Sep 2026

New funding supports LMU research on pediatric inflammatory bowel disease

The non-profit Boehringer Ingelheim Stiftung supports LMU clinician-scientist Daniel Kotlarz through its Rise up! program.

10 Sep 2026

Scientists develop lab-grown heart tissue model for heart failure

Scientists study the underlying causes of a disease or test new potential drugs in animal models or cells obtained from human biopsy specimens before clinical trials.

2 Sep 2026

Bridging science and family story to understand schizophrenia origins

Twin studies have placed the heritability of schizophrenia at roughly eighty percent for decades. Concordance between identical twins, who share the entire genome, does not reach fifty percent. Both figures are well established, and they do not fit together comfortably.

2 Sep 2026

Stanford scientists develop an ultracompact gene activation tool

The ability to precisely adjust the expression of genes inside the human body - ramping up protective ones and tamping down harmful ones - holds enormous potential for treating and preventing disease.

28 Aug 2026

Scalable stem cell method advances off-the-shelf CAR-T therapies

Researchers at the Center for Regenerative Medicine (CReM) at Boston Medical Center (BMC) and Boston University (BU) have developed a scalable method for generating CD4+ helper T cells from induced pluripotent stem cells (iPSCs), overcoming a longstanding challenge in the development of stem cell-based immunotherapies.

27 Aug 2026

Multi-organ chip uncovers key mechanisms behind cancer metastasis

Cancer spreading beyond the primary tumor – a process known as metastasis – is responsible for at least two-thirds of cancer deaths.

19 Aug 2026

Mass-producible immune cells fight solid human tumors in mice

Off-the-shelf and mass-producible immune cells fight solid human tumors engrafted into mice. The Kobe University development is a significant contribution towards faster and cheaper cancer immunotherapy.

23 Jul 2026

Researchers use canine iPSCs to generate red blood cell-like cells

Blood transfusions are crucial in human and veterinary medicine, yet human blood reserves are in constant need of donors while blood bank systems in veterinary care are nearly non-existent.

19 Jul 2026

New genetic reference map accelerates human stem cell research

A team led by bioengineers at the University of California San Diego has developed a genome-scale reference map that details how individual genes control the functions and identities of human stem cells.

13 Jul 2026

Off-the-shelf CAR T therapy targets treatment-resistant systemic sclerosis

Today at ISSCR 2026, new preliminary clinical data was presented evaluating an induced pluripotent stem cell (iPSC)-derived CAR T-cell therapy for patients with treatment-resistant systemic sclerosis, a rare autoimmune disease with high mortality.

9 Jul 2026

Stem cell study uncovers molecular pathway for enamel regeneration

Tooth enamel is the hardest substance in the human body, yet once damaged, it cannot regenerate naturally.

9 Jul 2026

Researchers advance fertility options for childhood cancer survivors

Researchers at Karolinska Institutet have demonstrated that it is possible to create early germ cells from preserved testicular tissue of young boys facing cancer therapy.

3 Jul 2026

Duke engineers grow retinal blood vessel cells from pluripotent stem cells

Biomedical engineers at Duke University have used induced pluripotent stem cells (iPSCs) to grow specialized blood vessel cells critical to retinal health for the first time.

30 Jun 2026

New diagnostic tool bypasses blood-brain barrier to detect autism early

A study published in NeuroMarkers showed that a nanosensor can measure nitric oxide (NO) from patient-derived stem cells to distinguish autism spectrum disorder (ASD) from intellectual disability (ID), even when both conditions share the exact same genetic mutation.

30 Jun 2026